Entrepreneurship, economic conditions, and the great recession

Abstract The "Great Recession" resulted in many business closings and foreclosures, but what effect did it have on business formation? On the one hand, recessions decrease potential business income and wealth, but on the other hand they restrict opportunities in the wage/salary sector leaving the net effect on entrepreneurship ambiguous. The most up-to-date microdata available --the 1996 to 2009 Current Population Survey (CPS) --are used to conduct a detailed analysis of the determinants of entrepreneurship at the individual level to shed light on this question. Regression estimates indicate that local labor market conditions are a major determinant of entrepreneurship. Higher local unemployment rates are found to increase the probability that individuals start businesses. Home ownership and local home values for home owners are also found to have positive effects on business creation, but these effects are noticeably smaller. Additional regression estimates indicate that individuals who are initially not employed respond more to high local unemployment rates by starting businesses than wage/salary workers. The results point to a consistent picture -the positive influences of slack labor markets outweigh the negative influences resulting in higher levels of business creation. Using the regression estimates for the local unemployment rate effects, I find that the predicted trend in entrepreneurship rates tracks the actual upward trend in entrepreneurship extremely well in the Great Recession

Imaging Fabry-Perot Spectroscopy of NGC 5775: Kinematics of the Diffuse Ionized Gas Halo

We present imaging Fabry-Perot observations of Halpha emission in the nearly edge-on spiral galaxy NGC 5775. We have derived a rotation curve and a radial density profile along the major axis by examining position-velocity (PV) diagrams from the Fabry-Perot data cube as well as a CO 2-1 data cube from the literature. PV diagrams constructed parallel to the major axis are used to examine changes in azimuthal velocity as a function of height above the midplane. The results of this analysis reveal the presence of a vertical gradient in azimuthal velocity. The magnitude of this gradient is approximately 1 km/s/arcsec, or about 8 km/s/kpc, though a higher value of the gradient may be appropriate in localized regions of the halo. The evidence for an azimuthal velocity gradient is much stronger for the approaching half of the galaxy, although earlier slit spectra are consistent with a gradient on both sides. There is evidence for an outward radial redistribution of gas in the halo. The form of the rotation curve may also change with height, but this is not certain. We compare these results with those of an entirely ballistic model of a disk-halo flow. The model predicts a vertical gradient in azimuthal velocity which is shallower than the observed gradient, indicating that an additional mechanism is required to further slow the rotation speeds in the halo.Comment: 18 pages, 18 figures. Uses emulateapj.cls. Accepted for publication in Ap

History of Deer Herd Reduction for Tick Control on Maine’s Offshore Islands

The incidence of Lyme disease in Maine is associated with high abundance of blacklegged (deer) ticks, which in turn has been partly attributed to local overabundance of white-tailed deer. With evidence from Monhegan Island that the complete removal of deer reduced ticks and risk of contracting Lyme disease, nine other offshore communities initiated efforts to cull deer. We reviewed and summarized available histories of deer management on Maine’s offshore islands. Concern about Lyme disease provided the overarching impetus for deer culls. Culls mostly occurred on islands that have no regular firearms hunting season, island communities have been challenged to control deer numbers, and social acceptance of deer culls varied. Integrated tick management (ITM) is the key to controlling ticks, but statewide ITM policy is lacking. Formation of vector control districts with statewide ITM policy would support all communities in Maine

Integral Field Unit Observations of NGC 4302: Kinematics of the Diffuse Ionized Gas Halo

We present moderate resolution spectroscopy of extraplanar diffuse ionized gas (EDIG) emission in the edge-on spiral galaxy NGC 4302. The spectra were obtained with the SparsePak integral field unit (IFU) at the WIYN Observatory. The spectra are used to construct position-velocity (PV) diagrams at several ranges of heights above the midplane. Azimuthal velocities are directly extracted from the PV diagrams using the envelope tracing method, and indicate an extremely steep dropoff in rotational velocity with increasing height, with magnitude ~30 km/s/kpc. We find evidence for a radial variation in the velocity gradient on the receding side. We have also performed artificial observations of galaxy models in an attempt to match the PV diagrams. The results of a statistical analysis also favor a gradient of ~30 km/s/kpc. We compare these results with an entirely ballistic model of disk-halo flow, and find a strong dichotomy between the observed kinematics and those predicted by the model. The disagreement is worse than we have found for other galaxies in previous studies. The conclusions of this paper are compared to results from two other galaxies, NGC 5775 and NGC 891. We find that the vertical gradient in rotation speed, per unit EDIG scale height, for all three galaxies is consistent with a constant magnitude (within the errors) of approximately 15-25 km/s/scaleheight, independent of radius. This relationship is also true within the galaxy NGC 4302. We also discuss how the gradient depends on the distribution and morphology of the EDIG and the star formation rates of the galaxies, and consequences for the origin of the gas.Comment: 37 pages, 10 figures; accepted for publication in the Astrophysical Journa

A Trade Secret Model for Genomic Biobanking

Genomic biobanks present ethical challenges that are qualitatively unique and quantitatively unprecedented. Many critics have questioned whether the current system of informed consent can be meaningfully applied to genomic biobanking. Proposals for reform have come from many directions, but have tended to involve incremental change in current informed consent practice. This paper reports on our efforts to seek new ideas and approaches from those whom informed consent is designed to protect: research subjects. Our model emerged from semi-structured interviews with healthy volunteers who had been recruited to join either of two biobanks (some joined, some did not), and whom we encouraged to explain their concerns and how they understood the relationship between specimen contributors and biobanks. These subjects spoke about their DNA and the information it contains in ways that were strikingly evocative of the legal concept of the trade secret. They then described the terms and conditions under which they might let others study their DNA, and there was a compelling analogy to the commonplace practice of trade secret licensing. We propose a novel biobanking model based on this trade secret concept, and argue that it would be a practical, legal, and ethical improvement on the status quo

Large-scale shock-ionized and photo-ionized gas in M83: the impact of star formation

We investigate the ionization structure of the nebular gas in M83 using the line diagnostic diagram, [O III](5007 \degA)/H{\beta} vs. [S II](6716 \deg A+6731 \deg A)/H{\alpha} with the newly available narrowband images from the Wide Field Camera 3 (WFC3) of the Hubble Space Telescope (HST). We produce the diagnostic diagram on a pixel-by-pixel (0.2" x 0.2") basis and compare it with several photo- and shock-ionization models. For the photo-ionized gas, we observe a gradual increase of the log([O III]/H{\beta}) ratios from the center to the spiral arm, consistent with the metallicity gradient, as the H II regions go from super solar abundance to roughly solar abundance from the center out. Using the diagnostic diagram, we separate the photo-ionized from the shock-ionized component of the gas. We find that the shock-ionized H{\alpha} emission ranges from ~2% to about 15-33% of the total, depending on the separation criteria used. An interesting feature in the diagnostic diagram is an horizontal distribution around log([O III]/H{\beta}) ~ 0. This feature is well fit by a shock-ionization model with 2.0 Z\odot metallicity and shock velocities in the range of 250 km/s to 350 km/s. A low velocity shock component, < 200 km/s, is also detected, and is spatially located at the boundary between the outer ring and the spiral arm. The low velocity shock component can be due to : 1) supernova remnants located nearby, 2) dynamical interaction between the outer ring and the spiral arm, 3) abnormal line ratios from extreme local dust extinction. The current data do not enable us to distinguish among those three possible interpretations. Our main conclusion is that, even at the HST resolution, the shocked gas represents a small fraction of the total ionized gas emission at less than 33% of the total. However, it accounts for virtually all of the mechanical energy produced by the central starburst in M83.Comment: Accepted for publication in ApJ. aastex preprint 12pt, 21 pages, 13 figure

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Importance:Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders. Objectives:To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma. Design, Settings, and Participants:A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma. Exposures:Genetic variants associated with primary open-angle glaucoma. Main Outcomes and Measures:Presence of primary open-angle glaucoma. Genome-wide significance was defined as P &lt; 5 × 10-8 in the discovery stage and in the meta-analysis of combined discovery and validation data. Results:A total of 2320 individuals with primary open-angle glaucoma (mean [interquartile range] age, 64.6 [56-74] years; 1055 [45.5%] women) and 2121 individuals without primary open-angle glaucoma (mean [interquartile range] age, 63.4 [55-71] years; 1025 [48.3%] women) were included in the discovery GWAS. The GWAS discovery meta-analysis demonstrated association of variants at amyloid-β A4 precursor protein-binding family B member 2 (APBB2; chromosome 4, rs59892895T&gt;C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P &lt; .001). Each copy of the rs59892895*C risk allele was associated with increased risk of primary open-angle glaucoma when all data were included in a meta-analysis (OR, 1.19 [95% CI, 1.14-1.25]; P = 4 × 10-13). The rs59892895*C risk allele was present at appreciable frequency only in African ancestry populations. In contrast, the rs59892895*C risk allele had a frequency of less than 0.1% in individuals of European or Asian ancestry. Conclusions and Relevance:In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry. If validated in additional populations this finding may have implications for risk assessment and therapeutic strategies