The Northern Navajo Frontier 1860-1900

The Navajo nation is one of the most frequently researched groups of Indians in North America. Anthropologists, sociologists, historians, and others have taken turns explaining their views of Navajo history and culture. A recurrent theme throughout is that the U.S. government defeated the Navajos so soundly during the early 1860s that after their return from incarceration at Bosque Redondo, they were a badly shattered and submissive people. The next thirty years saw a marked demographic boom during which the Navajo population doubled. Historians disagree as to the extent of this growth, but the position taken by many historians is that because of this growth and the rapidly expanding herds of sheep, cattle, and horses, the government beneficently gave more territory to its suffering wards. While this interpretation is partly accurate, it centers on the role of the government, the legislation that was passed, and the frustrations of the Indian agents who rotated frequently through the Navajo Agency in Fort Defiance, New Mexico, and ignores or severely limits one of the most important actors in this process of land acquisition-the Navajos themselves. Instead of being a downtrodden group of prisoners, defeated militarily in the 1860s and dependent on the U.S. government for protection and guidance in the 1870s and 80s, they were vigorously involved in defending and expanding the borders of their homelands. This was accomplished not through war and as a concerted effort, but by an aggressive defensive policy built on individual action that varied with changing circumstances. Many Navajos never made the Long Walk to Bosque Redondo. Instead they eluded capture in northern and western hinterlands and thereby pushed out their frontier. This book focuses on the events and activities in one part of the Navajo borderlands-the northern frontier-where between 1860 and 1900 the Navajos were able to secure a large portion of land that is still part of the reservation. This expansion was achieved during a period when most Native Americans were losing their lands.https://digitalcommons.usu.edu/usupress_pubs/1053/thumbnail.jp

The Journey of Navajo Oshley

Ak\u27é Nýdzin, or Navajo Oshley, was born sometime between 1879 and 1893. His oral memoir is set on the northern frontier of Navajo land, principally the San Juan River basin in southeastern Utah, and tells the story of his early life near Dennehetso and his travels, before there were roads or many towns, from Monument Valley north along Comb Ridge to Blue Mountain. During the late 19th and early 20th centuries, Anglos and Navajos expanded their use and settlement of lands north of the San Juan. Grazing lands and the Anglo wage economy drew many Navajos across the river. Oshley, a sheepherder, was among the first to settle there. He cared for the herds of his extended family, while also taking supplemental jobs with the growing livestock industry in the area. His narrative is woven with vivid and detailed portraits of Navajo culture: clan relationships, marriages and children, domestic life, the importance of livestock, complex relations with the natural world, ceremonies, trading, and hand trembling.https://digitalcommons.usu.edu/usupress_pubs/1051/thumbnail.jp

River Flowing from the Sunrise: An Environmental History of the Lower San Juan

The authors recount twelve millennia of history along the lower San Juan River, much of it the story of mostly unsuccessful human attempts to make a living from the river\u27s arid and fickle environment. From the Anasazi to government dam builders, from Navajo to Mormon herders and farmers, from scientific explorers to busted miners, the San Juan has attracted more attention and fueled more hopes than such a remote, unpromising, and muddy stream would seem to merit.https://digitalcommons.usu.edu/usupress_pubs/1127/thumbnail.jp

Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer.

We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss of the variant allele. Another proband had a nonsense variant in PALB2 with somatic loss of the variant allele. Both variants were absent in a relative with FPC. These findings question the causal mechanisms of ATM and PALB2 in these families and highlight challenges in identifying the causes of familial cancer syndromes using exome sequencing

Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity

<p>Abstract</p> <p>Background</p> <p>Obesity is reaching epidemic proportions and represents a significant risk factor for cardiovascular disease, diabetes, and cancer.</p> <p>Methods</p> <p>To explore the relationship between increased body mass and gene expression in blood, we conducted whole-genome expression profiling of whole blood from seventeen obese and seventeen well matched lean subjects. Gene expression data was analyzed at the individual gene and pathway level and a preliminary assessment of the predictive value of blood gene expression profiles in obesity was carried out.</p> <p>Results</p> <p>Principal components analysis of whole-blood gene expression data from obese and lean subjects led to efficient separation of the two cohorts. Pathway analysis by gene-set enrichment demonstrated increased transcript levels for genes belonging to the "ribosome", "apoptosis" and "oxidative phosphorylation" pathways in the obese cohort, consistent with an altered metabolic state including increased protein synthesis, enhanced cell death from proinflammatory or lipotoxic stimuli, and increased energy demands. A subset of pathway-specific genes acted as efficient predictors of obese or lean class membership when used in Naive Bayes or logistic regression based classifiers.</p> <p>Conclusion</p> <p>This study provides a comprehensive characterization of the whole blood transcriptome in obesity and demonstrates that the investigation of gene expression profiles from whole blood can inform and illustrate the biological processes related to regulation of body mass. Additionally, the ability of pathway-related gene expression to predict class membership suggests the feasibility of a similar approach for identifying clinically useful blood-based predictors of weight loss success following dietary or surgical interventions.</p

Psychopathology of adolescents with an intellectual disability who present to general hospital services

Objective: Adolescents with intellectual disability have increased rates of psychopathology compared with their typically developing peers and present to hospital more frequently for ambulant conditions. The aim of this study is to describe the psychopathology and related characteristics of a sample of adolescents with intellectual disability who presented to general hospital services

Taxonomy Working Group Final Report

The purpose of the Taxonomy Working Group was to develop a proposal for a common taxonomy to be used by all NASA projects in the classifying of nonconformances, anomalies, and problems. Specifically, the group developed a recommended list of data elements along with general suggestions for the development of a problem reporting system to better serve NASA's need for managing, reporting, and trending project aberrant events. The Group's recommendations are reported in this document