Intelligent design guidance

This paper presents results from an investigation regarding the use of the Design Structure Matrix (DSM) as a means to guide a designer through the calculation of numerical relationships within the early design system Designer. Characteristics, relationships and goals are used within Designer to enable the evaluation and approximation of the design model and are represented within the system as a digraph. Despite being a useful representation of the interactions within the design model, the digraph does not aid the designer in identifying a sequence of activities that need to be performed in order to evaluate the model. The DSM system was used to represent the characteristics and the dependencies obtained through the relationships. The sequence of characteristics within the DSM was optimised and used to produce a design process to guide the designer in model evaluation. The objective of the optimisation was to minimise the amount of iteration within the design process. The process enabled a designer who is unfamiliar with the model to evaluate it and satisfy the design goals and requirements. Both the DSM system and the Designer system are generic in nature andmay be applied to any design problem

Portable dynamic fundus instrument

A portable diagnostic image analysis instrument is disclosed for retinal funduscopy in which an eye fundus image is optically processed by a lens system to a charge coupled device (CCD) which produces recordable and viewable output data and is simultaneously viewable on an electronic view finder. The fundus image is processed to develop a representation of the vessel or vessels from the output data

Comparison of markets for organic food in six EU states.

This report was presented at the UK Organic Research 2002 Conference. Recent research confirms that the decision to convert is now highly influenced by financial incentives arising from EU regulations but the exact mix of incentives depends on prevailing government policies and access to premium markets so that the organic sector in most countries is now referred to as either government-led or market-driven. The objective of the paper is to compare development of the sector along these two polarities but set within the context of "common elements of interest" within new agrifood methodologies: time, space, power, and meaning (Cooke, Uranga and Etxebarria 1998; Morgan and Murdoch 2000). The paper presents preliminary findings relating to six EU States: UK, Ireland, Austria, Denmark, Portugal and Italy, and through the application of "worlds of production" to market outlets and suggests discourses that define these outlets. The analysis aims to inform the further study of farmer marketing decisions and practices

Contriibutors to the March Issue/Notes

Notes by Robert J. Callahan, John Kelly, William A. Meehan, Joseph R. Rudd, Arthur M. Diamond, John J. Doyle, Robert E. Sullivan, Roger Gustafson, William F. Martin, Robert A. Macdonell, Robert E. Million, Arthur A. May, and John F. Power

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo

Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Debris from these dying SCS macrophages is internalized by monocytes recruited from the circulation. This coordinated response leads to antigen presentation by monocytes and interactions with naïve CD4 T cells that can drive the initiation of T cell and B cell responses. These studies demonstrate an entirely novel pathway leading to initiation of adaptive immune responses in vivo