Marketing strategy:a history of the next decade

Editoria

On the evolution of the inner disk radius with flux in the neutron star low-mass X-ray binary Serpens X-1

We analyze the latest \emph{Suzaku} observation of the bright neutron star low-mass X-ray binary Serpens X-1 taken in 2013 October and 2014 April. The observation was taken using the burst mode and only suffered mild pile-up effects. A broad iron line is clearly detected in the X-ray spectrum. We test different models and find that the iron line is asymmetric and best interpreted by relativistic reflection. The relativistically broadened iron line is generally believed to originate from the innermost regions of the accretion disk, where strong gravity causes a series of special and general relativistic effects. The iron line profile indicates an inner radius of $\sim8$ $R_{\rm G}$, which gives an upper limit on the size of the neutron star. The asymmetric iron line has been observed in a number of previous observations, which gives several inner radius measurements at different flux states. We find that the inner radius of Serpens X-1 does not evolve significantly over the range of $L/L_{\rm Edd}\sim0.4-0.6$, and the lack of flux dependence of the inner radius implies that the accretion disk may be truncated outside the innermost stable circular orbit by the boundary layer rather than the stellar magnetic field.Comment: 8 pages, 6 figures, accepted for publication in Ap

Photoacoustic ultrasound sources from diffusion-limited aggregates

Metallic diffusion-limited aggregate (DLA) films are well-known to exhibit near-perfect broadband optical absorption. We demonstrate that such films also manifest a substantial and relatively material-independent photoacoustic response, as a consequence of their random nanostructure. We theoretically and experimentally analyze photoacoustic phenomena in DLA films, and show that they can be used to create broadband air- coupled acoustic sources. These sources are inexpensive and simple to fabricate, and work into the ultrasonic regime. We illustrate the device possibilities by building and testing an optically-addressed acoustic phased array capable of producing virtually arbitrary acoustic intensity patterns in air.Comment: 5 pages, 5 figure

3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography.

Outer Hair Cells (OHCs) in the mammalian cochlea display a unique type of voltage-induced mechanical movement termed electromotility, which amplifies auditory signals and contributes to the sensitivity and frequency selectivity of mammalian hearing. Electromotility occurs in the OHC lateral wall, but it is not fully understood how the supramolecular architecture of the lateral wall enables this unique form of cellular motility. Employing electron tomography of high-pressure frozen and freeze-substituted OHCs, we visualized the 3D structure and organization of the membrane and cytoskeletal components of the OHC lateral wall. The subsurface cisterna (SSC) is a highly prominent feature, and we report that the SSC membranes and lumen possess hexagonally ordered arrays of particles. We also find the SSC is tightly connected to adjacent actin filaments by short filamentous protein connections. Pillar proteins that join the plasma membrane to the cytoskeleton appear as variable structures considerably thinner than actin filaments and significantly more flexible than actin-SSC links. The structurally rich organization and rigidity of the SSC coupled with apparently weaker mechanical connections between the plasma membrane (PM) and cytoskeleton reveal that the membrane-cytoskeletal architecture of the OHC lateral wall is more complex than previously appreciated. These observations are important for our understanding of OHC mechanics and need to be considered in computational models of OHC electromotility that incorporate subcellular features

Applications of satellite technology to broadband ISDN networks

Two satellite architectures for delivering broadband integrated services digital network (B-ISDN) service are evaluated. The first is assumed integral to an existing terrestrial network, and provides complementary services such as interconnects to remote nodes as well as high-rate multicast and broadcast service. The interconnects are at a 155 Mbs rate and are shown as being met with a nonregenerative multibeam satellite having 10-1.5 degree spots. The second satellite architecture focuses on providing private B-ISDN networks as well as acting as a gateway to the public network. This is conceived as being provided by a regenerative multibeam satellite with on-board ATM (asynchronous transfer mode) processing payload. With up to 800 Mbs offered, higher satellite EIRP is required. This is accomplished with 12-0.4 degree hopping beams, covering a total of 110 dwell positions. It is estimated the space segment capital cost for architecture one would be about $190M whereas the second architecture would be about$250M. The net user cost is given for a variety of scenarios, but the cost for 155 Mbs services is shown to be about $15-22/minute for 25 percent system utilization

Book Reviews

Book Reviews The Fifth Amendment Today By Erwin N. Griswold Cambridge)Mass.: Harvard University Press. Pp. vi, 82. $0.50 reviewer: Robert J. Harris Handbook of the Law of Evidence By Charles T, McCormick St.Paul: West Publishing Co., 1954, pp. xxviii, 774. reviewer: E. M. Morga

Phylogenetic Tests of Models of Viral Transmission

The hunt for the immediate non-human host of SARS-CoV-2 has centered on bats of the genus Rhinolophus. We explored the phylogenetic predictions of two models of viral transmission, the SpilloverModel and the CirculationModel and suggest that the Spillover Model can be eliminated. The Circulation Model suggests that viral transmission occurs among susceptible hosts irrespective of their phylogenetic relationships. Susceptibility could be mediated by the ACE2 gene (important for viral docking) and we constructed a phylogeny of this gene for 159 mammal species, finding a phylogenetic pattern consistent with established mammalian relationships. The tree indicates that viral transfer occurs over large evolutionary distances. Although lacking consensus, some studies identify a virus from a particular R. affinis individual (RaTG13) as being most closely related phylogenetically to human SARS-CoV-2. However, other R. affinis harbor viruses that are relatively unrelated to human viruses, and viruses found in this species exhibit sequence differences of up to 20%, suggesting multiple transfers over time. There is little correspondence between viral and host (bat) species limits or phylogenetic relationships. An ACE2 phylogeny for Rhinolophus followed species limits, unlike the pattern in the viral phylogeny indicating that phylogenetic similarity of ACE2 is not a predictor of viral transmission at the bat species level. The Circulation Model could be modified to apply to any individual of any species of Rhinolophus; more individuals and species must be examined