24 research outputs found
Trends in influenza vaccination coverage rates in Germany over five seasons from 2001 to 2006
BACKGROUND: To assess influenza vaccination coverage from 2001 to 2006 in Germany, to understand drivers and barriers to vaccination and to identify vaccination intentions for season 2006/07. METHODS: 9,990 telephone-based household surveys from age 14 were conducted between 2001 and 2006. Essentially, the same questionnaire was used in all seasons. RESULTS: The influenza vaccination coverage rate reached 32.5% in 2005/06. In the elderly (> or years), the vaccination rate reached 58.9% in 2005/06. In those aged 65 years and older, it was 63.4%. Perceiving influenza as a serious illness was the most frequent reason for getting vaccinated. Thirteen percent of those vaccinated in 2005/06 indicated the threat of avian flu as a reason. The main reason for not getting vaccinated was thinking about it without putting it into practice. The major encouraging factor to vaccination was a recommendation by the family doctor. 49.6% of the respondents intend to get vaccinated against influenza in season 2006/07. CONCLUSION: Increasing vaccination rates were observed from 2001 to 2006 in Germany. The threat of avian influenza and the extended reimbursement programs may have contributed to the recent increase
Figure S2: Scatterplots for the number of recorded PUUV infections per 100,000 inhabitants and four environmental factors that are supposed to be relevant
Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure
Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany
A live attenuated vaccine (Zostavax®)
against herpes zoster (HZ) and postherpetic
neuralgia (PHN) was licensed for
persons 50 years of age and older in 2006
and became available in Germany in September
2013. Based on the conclusion,
that an effective and sustainable reduction
of the HZ disease burden cannot be
achieved with this vaccine, the STIKO
decided against issuing a recommendation
for routine HZ vaccination at this
time. This decision is based on a systematic
review of available data on the efficacy,
duration of protection, and safety of
the vaccine, and is supported by the results
of health economic modelling. Both,
the risk of developing HZ and the severity
of the illness increase markedly with age.
The efficacy of the vaccine, however, decreases
with advancing age, from 70% for
persons in their 50s to 41% for persons in
their 70s to less than 20% for persons 80
years of age and older. The duration of vaccine
related protection is limited to only
a few years. The modelling results show
only a slight, age-dependent reduction in
the total number of HZ cases through vaccination
with the live attenuated vaccine.
The reduction ranged from 2.6% for persons
vaccinated at the age of 50 to 0.6%
for those vaccinated at the age of 80, based
on assumed vaccine coverage of 35.5%. In
addition to the vaccine’s poor efficacy and
duration of protection, HZ vaccination
does not offer any added value in terms of
herd immunity, since HZ is a disease of an
endogenously reactivated pathogen with
low transmission potential.
Finally, the live attenuated vaccine is
often contraindicated in persons who are
at greatest risk of HZ and its complications.
Thus, in the overall appraisal, the
epidemiological benefit-risk assessment
of the HZ vaccination did not lead to a
recommendation for routine vaccination
with the live attenuated vaccine. An individual
benefit-risk assessment may, however,
lead to a different decision in individual
patients.Peer Reviewe