Results of the 1976 southern California pismo clam census

A Pismo clam, Tivela stultorum, census was conducted in January 1976 on selected southern California beaches. Effort and catch information was collected through clamer interviews. Estimates for January 17 on beaches sampled were 3,296 clammer-hours, 2,170 clammers, and 10,739 legal clams (4.5 inches or larger) harvested. Clams were collected for age and growth studies. Samples of clams from the Long Beach to Newport Beach pier area demonstrate the fastest growth rates of any Pismo clams reported in the literature. Clams begin to be recruited to the fishery at age 40 months. (14pp.) The 1974 year class was the largest on beaches sampled. Recruitment to the fishery will be poor for the 1976-77 and 1977-78 seasons and clamming will be dependent on large older clams

Antireflective coating for glass applications and method of forming same

One aspect of the disclosure is directed to a method for forming an antireflective coating on a substrate, which includes providing a polymer solution and a silica solution, depositing the polymer solution on a surface of the substrate to forming a polymer film thereon, depositing the silica solution on the formed polymer film on the substrate to form a silica film thereon, thereby forming a stack structure having the silica film formed on the polymer film that is, in turn, formed on the substrate, and drying the stack structure to form the antireflective coating on the substrate, wherein the antireflective coating comprises silica nanoparticles

Altitude-wind-tunnel investigation of Westinghouse 19B-2, 19B-8, and 19XB-1 jet-propulsion engines III : performance and windmilling drag characteristics

The performance characteristics of the 19B-8 and 19XB-1 turbojet engines and the windmilling drag characteristics of the 19B-8 engine were determined in the NACA Cleveland altitude wind tunnel. The 19B engine is one of the earliest experimental Westinghouse axial-flow engines. The 19XB-1 engine is an experimental prototype of the Westinghouse 19XB series, having a rated thrust of 1400 pounds. Improvements in performance and operational characteristics have resulted in the 19XB-2B engine with a rated thrust of 1600 pounds. The investigations were conducted on the 19B-8 engine at simulated altitudes from 5000 to 25,000 feet with various free-stream ram-pressure ratios and on the 19XB-1 engine at simulated altitudes from 5000 to 30,000 feet with approximately static free-stream conditions. Data for these two engines are presented to show the effect of altitude, free-stream ram-pressure ratio, and tail-pipe-nozzle area on engine performance

Three-Dimensional Geometric Morphometric Analysis of Fossil Canid Mandibles and Skulls

Acknowledgements We thank C.P. Klingenberg for critical discussion of methodology. A. Drake and R. Losey were supported by a grant from the Social Sciences and Humanities Research Council of Canada grant (#SSHRC IG 435-2014-0075) and a European Research Council Grant to D. Anderson (#295458). M. Sablin acknowledges participation of ZIN RAS (state assignment № АААА-А17-117022810195-3) to this research. Supplementary information accompanies this paper at doi:10.1038/s41598-017-10232-1Peer reviewedPublisher PD

Higher-Loop Corrections to the Infrared Evolution of a Gauge Theory with Fermions

We consider a vectorial, asymptotically free gauge theory and analyze the effect of higher-loop corrections to the beta function on the evolution of the theory from the ultraviolet to the infrared. We study the case in which the theory contains $N_f$ copies of a fermion transforming according to the fundamental representation and several higher-dimensional representations of the gauge group. We also calculate higher-loop values of the anomalous dimension of the mass, $\gamma_m$ of $\bar\psi\psi$ at the infrared zero of the beta function. We find that for a given theory, the values of $\gamma_m$ calculated to three- and four-loop order, and evaluated at the infrared zero computed to the same order, tend to be somewhat smaller than the value calculated to two-loop order. The results are compared with recent lattice simulations.Comment: 22 pages, latex, matches Phys. Rev. D publicatio

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts.

Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS on FFPE samples is limited by poor RNA purification methods. To address this hurdle, we developed an improved methodology for extracting high-quality RNA from FFPE samples. By briefly integrating a newly-designed micro-homogenizing (mH) tool with commercially available FFPE RNA extraction protocols, RNA recovery is increased by approximately 3-fold while maintaining standard A260/A280 ratios and RNA quality index (RQI) values. Furthermore, we demonstrate that the mH-purified FFPE RNAs are longer and of higher integrity. Previous studies have suggested that pancreatic ductal adenocarcinoma (PDAC) gene expression signatures vary significantly under in vitro versus in vivo and in vivo subcutaneous versus orthotopic conditions. By using our improved mH-based method, we were able to preserve established expression patterns of KRas-dependency genes within these three unique microenvironments. Finally, expression analysis of novel biomarkers in KRas mutant PDAC samples revealed that PEAK1 decreases and MST1R increases by over 100-fold in orthotopic versus subcutaneous microenvironments. Interestingly, however, only PEAK1 levels remain elevated in orthotopically grown KRas wild-type PDAC cells. These results demonstrate the critical nature of the orthotopic tumor microenvironment when evaluating the clinical relevance of new biomarkers in cells or patient-derived samples. Furthermore, this new mH-based FFPE RNA extraction method has the potential to enhance and expand future FFPE-RNA-NGS cancer biomarker studies

Guidance of sentinel lymph node biopsy decisions in patients with T1-T2 melanoma using gene expression profiling.

AIM: Can gene expression profiling be used to identify patients with T1-T2 melanoma at low risk for sentinel lymph node (SLN) positivity? PATIENTS & METHODS: Bioinformatics modeling determined a population in which a 31-gene expression profile test predicted \u3c5% SLN positivity. Multicenter, prospectively-tested (n = 1421) and retrospective (n = 690) cohorts were used for validation and outcomes, respectively. RESULTS: Patients 55-64 years and ≥65 years with a class 1A (low-risk) profile had SLN positivity rates of 4.9% and 1.6%. Class 2B (high-risk) patients had SLN positivity rates of 30.8% and 11.9%. Melanoma-specific survival was 99.3% for patients ≥55 years with class 1A, T1-T2 tumors and 55.0% for class 2B, SLN-positive, T1-T2 tumors. CONCLUSION: The 31-gene expression profile test identifies patients who could potentially avoid SLN biopsy

Determining structural performance

An overview of the methods and concepts developed to enhance and predict structural dynamic characteristics of advanced aeropropulsion systems is presented. Aeroelasticity, vibration control, dynamic systems, and computational structural methods are four disciplines that make up the structural dynamic effort at LeRC. The aeroelasticity program develops analytical and experimental methods for minimizing flutter and forced vibration of aerospace propulsion systems. Both frequency domain and time domain methods were developed for applications on the turbofan, turbopump, and advanced turboprop. In order to improve life and performance, the vibration control program conceives, analyzes, develops, and demonstrates new methods for controlling vibrations in aerospace systems. Active and passive vibration control is accomplished with electromagnetic dampers, magnetic bearings, and piezoelectric crystals to control rotor vibrations. The dynamic systems program analyzes and verifies the dynamics of interacting systems, as well as develops concepts and methods for high-temperature dynamic seals. Work in this field involves the analysis and parametric identification of large, nonlinear, damped, stochastic systems. The computational structural methods program exploits modern computer science as an aid to the solutions of structural problems

Comments on Maki v. Frelk--Comparative v.Contributory Negligence: Should the Court or Legislature Decide?

Believing that the holdings and opinions in the case of Maki v. Frelkare significant legal developments, the Vanderbilt Law Review has solicited comments on these decisions, which it is now pleased to publish. These comments by six distinguished torts teachers and writers bear on the relative merits of comparative and contributory negligence, but more importantly, they discuss whether the judicial or legislative method is most appropriate for adoption of a rule of comparative negligence. It is hoped that these comments will be used as a sound basis for action, whether the problem arises before the courts or legislatures