Sensitivity to Hand Path Curvature during Reaching

People optimize reaching to make straight and smooth movements. We performed experiments characterizing human sensitivity to hand path deviations from a straight reach. Vision of the arm was blocked. Subjects either moved the hand along paths of constrained curvature, or a robot moved the relaxed limb along similar trajectories (active and passive conditions, respectively). Subjects responded after each trial whether or not they thought the movement curved convex right. In a series of three experiments, we tested the effects of modifying visual feedback of hand position to suppress curvature, isotonic muscle activation, and a distracter task on subjects ability to detect curvature during reaching. We found that both active reaching and artificial minimization of visual hand path deviations significantly decreased proprioceptive curvature sensitivity. Specifically, isotonic contraction of muscles antagonistic to the movement decreased sensitivity to curvature while agonistic contraction had no effect. The distracter task did not significantly affect proprioceptive sensitivity, though it did interfere with the detrimental effect of minimizing visual error feedback. These findings demonstrate that: 1) antagonist muscle activation decreases efficacy of proprioceptive feedback during hand path curvature estimation, and 2) vision\u27s dominance over proprioception can be manipulated by altering the attentional demands of the task

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats

The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats. Microinjection of the EAA agonists N-methyl-D-aspartic acid (NMDA; 1-10 pmol), alpha-amino-3-hydroxy-5-methyl-4-isooxazolepropionic acid (AMPA; 0.3-3.0 pmol), or kainic acid (0.1-1.0 pmol) into the dorsomedial hypothalamus (DMH) elicited dose-related increases in heart rate and modest elevations in arterial pressure. Local microinjection of the NMDA antagonist 2-amino-5-phosphonopentanoic acid (AP5; 100 pmol) selectively blocked NMDA-induced cardiovascular changes, whereas the non-NMDA EAA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 50 pmol) selectively blocked the responses to AMPA and kainic acid. In the stress trials, microinjection of the nonselective EAA antagonist kynurenic acid (1-10 nmol) into the DMH blocked air stress-induced tachycardia in a dose-related manner. Similar injection of kynurenic acid at sites lateral or posterior to the DMH or injection of xanthurenic acid (a structural analogue of kynurenic acid with no antagonistic properties at EAA receptors) into the DMH failed to influence air stress-induced cardiovascular changes. Injection of either AP5 or CNQX into the DMH at doses shown to be selective for their respective EAA receptor subtypes also attenuated air stress-induced tachycardia. Thus activity at EAA receptors in the DMH appears to be necessary for the generation of stress-induced changes in heart rate

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats

We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in emotional stress. The purpose of this study was to determine whether excitatory amino acids (EAAs) can produce a cardiovascular response similar to that caused by the GABAA receptor antagonist bicuculline methiodide (BMI) when microinjected at the same hypothalamic site in urethan-anesthetized rats and to clarify the precise locus of action of these agents. N-methyl-D-aspartic acid (NMDA, 0.68-6.8 pmol/50 nl) and kainic acid (KA, 0.47-4.7 pmol/50 nl) produced dose-related increases in heart rate and blood pressure when injected at sites in the dorsomedial hypothalamus reactive to BMI (20 pmol/50 nl). Higher doses of NMDA (68 pmol), however, failed to elicit consistent increases in heart rate and blood pressure when injected at these same sites. The effects of NMDA were selectively blocked by the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid, whereas the effects of KA were selectively blocked by the non-NMDA EAA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione. These results demonstrate that 1) blockade of inhibitory amino acid receptors or stimulation of EAA receptors in the dorsomedial nucleus of the hypothalamus produces tachycardic and pressor responses in urethan-anesthetized rats and 2) use of high doses of EAAs may be an unreliable method of evoking local neuronal excitation in certain regions of the central nervous system

The Culturally-adapted Early Pathways Program for Young Latino Children in Poverty: A Randomized Controlled Trial

This study used a randomized controlled design with treatment and wait-list conditions to evaluate the efficacy of a culturally adapted version of the Early Pathways program (EP; Fox & Gresl, 2014), an in-home, parent–child therapy program with 137 at-risk Latino children under the age of 6 referred for severe behavior and emotional problems, such as aggression, oppositional behavior, self-injury, and property destruction. EP directly engaged the parent–child dyad, emphasizing parent-directed training, child-led play, psychoeducation, and cognitive–behavioral strategies. Cultural modifications included establishing community partnerships to identify Latino family needs, translation of materials, offering bilingual services, acculturation assessment, and cultural competence training. Multivariate analyses of covariance (MANCOVA) revealed significant differences between the immediate and delayed treatment groups on all posttest measures with the pretest scores as covariates. After the delayed group completed treatment, repeated measures, multivariate analyses of variance (MANOVA) showed significant improvement for both groups on all measures with maintenance at 4- to 6-week follow-up. Outcomes included reduced child behavior problems, increased child prosocial behaviors, improved caregiver limit setting, enhanced caregiver nurturing, improved parent–child relationships, and a decrease in clinical diagnoses following treatment. This study highlights the efficacy of using culturally adapted early intervention services for young Latino children in poverty referred for significant behavior and emotional problems

Pursuing the planet-debris disk connection: Analysis of upper limits from the Anglo-Australian Planet Search

Solid material in protoplanetary discs will suffer one of two fates after the epoch of planet formation; either being bound up into planetary bodies, or remaining in smaller planetesimals to be ground into dust. These end states are identified through detection of sub-stellar companions by periodic radial velocity (or transit) variations of the star, and excess emission at mid- and far-infrared wavelengths, respectively. Since the material that goes into producing the observable outcomes of planet formation is the same, we might expect these components to be related both to each other and their host star. Heretofore, our knowledge of planetary systems around other stars has been strongly limited by instrumental sensitivity. In this work, we combine observations at far-infrared wavelengths by IRAS, Spitzer, and Herschel with limits on planetary companions derived from non-detections in the 16-year Anglo-Australian Planet Search to clarify the architectures of these (potential) planetary systems and search for evidence of correlations between their constituent parts. We find no convincing evidence of such correlations, possibly owing to the dynamical history of the disk systems, or the greater distance of the planet-search targets. Our results place robust limits on the presence of Jupiter analogs which, in concert with the debris disk observations, provides insights on the small-body dynamics of these nearby systems.Comment: Accepted for publication in A

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats

We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to stress. The purpose of this study was to examine the role of excitatory amino acid (EAA) receptors in the DMH in generating the cardiovascular changes caused by withdrawal of local GABAergic inhibition in urethan-anesthetized rats. Local treatment of the DMH with the nonselective EAA antagonist kynurenic acid blocked or reversed the increases in heart rate and blood pressure caused by microinjection of the GABAA antagonists bicuculline methiodide (BMI) or picrotoxin into the same region. Conversely, similar injection of xanthurenic acid, a structural analogue of kynurenic acid without significant effects on EAA receptors, did not significantly alter the cardiovascular changes produced by either GABAA antagonist. The tachycardic effects of BMI were also attenuated by injection of either the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonopentanoic acid or the non-NMDA EAA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione. When the two EAA receptor antagonists were combined, their effects to suppress the BMI-induced tachycardia were additive. These findings suggest that the cardiovascular effects caused by blockade of GABAergic inhibition in the DMH of the rat are dependent on activation of local NMDA and non-NMDA EAA receptors

Engineering an all-optical route to ultracold molecules in their vibronic ground state

We propose an improved photoassociation scheme to produce ultracold molecules in their vibronic ground state for the generic case where non-adiabatic effects facilitating transfer to deeply bound levels are absent. Formation of molecules is achieved by short laser pulses in a Raman-like pump-dump process where an additional near-infrared laser field couples the excited state to an auxiliary state. The coupling due to the additional field effectively changes the shape of the excited state potential and allows for efficient population transfer to low-lying vibrational levels of the electronic ground state. Repetition of many pump-dump sequences together with collisional relaxation allows for accumulation of molecules in v=0.Comment: Phys. Rev. A, in pres

Reynolds Pressure and Relaxation in a Sheared Granular System

We describe experiments that probe the evolution of shear jammed states, occurring for packing fractions $\phi_S \leq \phi \leq \phi_J$, for frictional granular disks, where above $\phi_J$ there are no stress-free static states. We use a novel shear apparatus that avoids the formation of inhomogeneities known as shear bands. This fixed $\phi$ system exhibits coupling between the shear strain, $\gamma$, and the pressure, $P$, which we characterize by the `Reynolds pressure', and a `Reynolds coefficient', $R(\phi) = (\partial ^2 P/\partial \gamma ^2)/2$. $R$ depends only on $\phi$, and diverges as $R \sim (\phi_c - \phi)^{\alpha}$, where $\phi_c \simeq \phi_J$, and $\alpha \simeq -3.3$. Under cyclic shear, this system evolves logarithmically slowly towards limit cycle dynamics, which we characterize in terms of pressure relaxation at cycle $n$: $\Delta P \simeq -\beta \ln(n/n_0)$. $\beta$ depends only on the shear cycle amplitude, suggesting an activated process where $\beta$ plays a temperature-like role.Comment: 4 pages, 4 figure

Robust Inference on Seasonal Unit Roots via a Bootstrap Applied to OECD Macroeconomic Series

Recent experimental results presented in Burridge and Taylor (2001a,b, and 2003) show that, as usually implemented, the Hylleberg et al. (1990) seasonal unit root tests can be rather liberal, with true level often substantially higher than nominal level. This effect is due to the presence of any of three things: data-based lag selection in the implementation of the tests, and either or both periodic heteroscedasticity and serial correlation in the driving shocks. Burridge and Taylor (2003) demonstrate that under experimental conditions a carefully implemented bootstrap substantially corrects test level without loss of power. The present study applies their technique to a large number of publicly available series, and demonstrates conclusively that the bootstrap produces less liberal, and, given the experimental results cited above, more reliable inference. We report results for Sweden, the UK and the US, which are typical of the fifteen countries in our panel. Other results, the GAUSS code, and raw data are all available at: www.staff.city.ac.uk/p.burridge

A neuro-collision avoidance strategy for robot manipulators

The area of collision avoidance and path planning in robotics has received much attention in the research community. Our study centers on a combination of an artificial neural network paradigm with a motion planning strategy that insures safe motion of the Articulated Two-Link Arm with Scissor Hand System relative to an object. Whenever an obstacle is encountered, the arm attempts to slide along the obstacle surface, thereby avoiding collision by means of the local tangent strategy and its artificial neural network implementation. This combination compensates the inverse kinematics of a robot manipulator. Simulation results indicate that a neuro-collision avoidance strategy can be achieved by means of a learning local tangent method