Fiber optic microphone having a pressure sensing reflective membrane and a voltage source for calibration purpose

A fiber optic microphone is provided for measuring fluctuating pressures. An optical fiber probe having at least one transmitting fiber for transmitting light to a pressure-sensing membrane and at least one receiving fiber for receiving light reflected from a stretched membrane is provided. The pressure-sensing membrane may be stretched for high frequency response. Further, a reflecting surface of the pressure-sensing membrane may have dimensions which substantially correspond to dimensions of a cross section of the optical fiber probe. Further, the fiber optic microphone can be made of materials for use in high temperature environments, for example greater than 1000 F. A fiber optic probe is also provided with a back plate for damping membrane motion. The back plate further provides a means for on-line calibration of the microphone

High temperature fiber optic microphone having a pressure-sensing reflective membrane under tensile stress

A fiber optic microphone is provided for measuring fluctuating pressures. An optical fiber probe having at least one transmitting fiber for transmitting light to a pressure-sensing membrane and at least one receiving fiber for receiving light reflected from a stretched membrane is provided. The pressure-sensing membrane may be stretched for high frequency response. Further, a reflecting surface of the pressure-sensing membrane may have dimensions which substantially correspond to dimensions of a cross section of the optical fiber probe. Further, the fiber optic microphone can be made of materials for use in high temperature environments, for example greater than 1000 F. A fiber optic probe is also provided with a backplate for damping membrane motion. The backplate further provides a means for on-line calibration of the microphone

Radiological assessment for Space Station Freedom

Circumstances have made it necessary to reassess the risks to Space Station Freedom crewmembers that arise from exposure to the space radiation environment. An option is being considered to place it in an orbit similar to that of the Russian Mir space station. This means it would be in a 51.6 deg inclination orbit instead of the previously planned 28.5 deg inclination orbit. A broad range of altitudes is still being considered, although the baseline is a 407 km orbit. In addition, recent data from the Japanese A-bomb survivors has made it necessary for NASA to have the exposure limits reviewed. Preliminary findings of the National Council on Radiation Protection and Measurements indicate that the limits must be significantly reduced. Finally, the Space Station will be a laboratory where effects of long-term zero gravity on human physiology will be studied in detail. It is possible that a few crewmembers will be assigned to as many as three 1-year missions. Thus, their accumulated exposure will exceed 1,000 days. Results of this radiation risk assessment for Space Station Freedom crewmembers finds that females less than 35 years old will be confined to mission assignments where the altitude is less than about 400 km. Slight restrictions may also need to be made for male crewmembers less than 35 years old

Observations of temporal changes of tritium-3He age in the eastern North Atlantic thermocline: Evidence for changes in ventilation

A compilation of fifteen years of tritium and 3He measurements is used to examine the ventilation of the eastern North Atlantic subtropical gyre with specific emphasis on the temporal character of the tracer age field. A multivariate regression analysis in the form of a spatiotemporal Taylor expansion is applied to observations interpolated onto isopycnal surfaces. The time-dependent component of the tracer age field is found to be statistically significant, explaining approximately 10% of the variance of the tracer age observations in the upper thermocline (σ = 26.5) and increasing to roughly 50% of the variance in the lower thermocline (σ = 27.0). The observed transient tracer age increases over the 15 years of observations with the fractional rate of change of the age field varying between 2% and 5% per year. The largest observed changes occur on the deepest, most slowly ventilated isopycnal surfaces. The second derivative of the tritium-3He age with time suggests that the tracer age field may be approaching a steady state. If tritium-3He age is interpreted as a true measure of the advective ventilation age, the temporal changes in age would imply a slackening of the ventilation of the lower main thermocline of greater than 50% from the late 1970\u27s to the early 1990\u27s. However, consideration of the full advective-diffusive balance of tritium-3He age reveals that the changes in tracer age field represent a time-dependent adjustment of the transient tracer concentrations in conjunction with a steady local circulation field. Integral approximations of the upstream evolution of the tracer field also fail to demonstrate evidence for decadal changes in ventilation. The integral balance along the path of subduction yields an improved estimate of the true ventilation age based on the temporal tendency of the age field along the path of ventilation. An approximation of this integral suggests that actual ventilation ages can be up to 40% larger than the measured tracer age in the deeper portions of the North Atlantic thermocline. Proper accounting of the time-dependent biases of the tracer age dating technique are a prerequisite for examining transient tracer measurements for evidence of changes in the physical ventilation of the upper ocean

Method for making a dynamic pressure sensor and a pressure sensor made according to the method

A method for providing a perfectly flat top with a sharp edge on a dynamic pressure sensor using a cup-shaped stretched membrane as a sensing element is described. First, metal is deposited on the membrane and surrounding areas. Next, the side wall of the pressure sensor with the deposited metal is machined to a predetermined size. Finally, deposited metal is removed from the top of the membrane in small steps, by machining or lapping while the pressure sensor is mounted in a jig or the wall of a test object, until the true top surface of the membrane appears. A thin indicator layer having a color contrasting with the color of the membrane may be applied to the top of the membrane before metal is deposited to facilitate the determination of when to stop metal removal from the top surface of the membrane

The Ursinus Weekly, November 25, 1963

John F. Kennedy buried at Arlington today: Assassination saddens world • Students react to news of murder • Assassination historically • President\u27s life in review • A statement about John Kennedy • Oswald murdered Sunday • Chapel service held in memory of Kennedy • Editorial: Riderless horse; Reign of reason • Letters to the editor • Students petition for corrective measures at 6th Ave. & Main St. • Candace Sprecher struck by auto • Student editors at Scranton\u27s press conference • Messiah to be presented Dec. 12 • Tara theme of Senior Ball • Donald Barnhouse, TV 10 newscaster to speak • Soviets speak at Phila. Council: UC students question • College group visits Saint Gabriels • Lyndon Baines Johnson sworn in as 36 President Friday November 22, 1963 • Lecture presented on Rome Council • Greek gleanings • Curtain Club\u27s first theatre in round production December 6 • Teacher exams to be given Feb. 15https://digitalcommons.ursinus.edu/weekly/1259/thumbnail.jp

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.

A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584, NCT01470794 and NCT01985256). Tumor-selective propagation of this RRV enables highly efficient transduction of glioma cells with cytosine deaminase (CD), which serves as a prodrug activator for conversion of the anti-fungal prodrug 5-FC to the anti-cancer drug 5-fluorouracil (5-FU) directly within the infected cells. We investigated whether, in addition to its direct cytotoxic effects, 5-FU generated intracellularly by RRV-mediated CD/5-FC prodrug activator gene therapy could also act as a radiosensitizing agent. Efficient transduction by RRV and expression of CD were confirmed in the highly aggressive, radioresistant human glioblastoma cell line U87EGFRvIII and its parental cell line U87MG (U87). RRV-transduced cells showed significant radiosensitization even after transient exposure to 5-FC. This was confirmed both in vitro by a clonogenic colony survival assay and in vivo by bioluminescence imaging analysis. These results provide a convincing rationale for development of tumor-targeted radiosensitization strategies utilizing the tumor-selective replicative capability of RRV, and incorporation of radiation therapy into future clinical trials evaluating Toca 511 and Toca FC in brain tumor patients

The subduction experiment : cruise report R/V Knorr : cruise number 138 leg XV : subduction 3 mooring recovery cruise, 13-30 June 1993

Subduction is the mechanism by which water masses formed in the mixed layer and near the surface of the ocean find their way into the upper thermocline. The subduction process and its underlying mechanisms were studied though a combination of Eulerian and Langrangian measurements of velocity, measurements of tracer distributions and hydrographic properties and modeling. An array of five surface moorings carrying meteorological and oceanographic instrumentation were deployed for a period of two years beginning in June 1991 as part of an Office of Naval Research (ONR) funded Subduction experiment. Three eight month deployments were planned. The moorings were deployed at 18°N 34°W, 18°N 22°W, 25.5°N 29°W, 33°N 22°W and 33°N 34°W. A Vector Averaging Wind Recorder (VAWR) and an Improved Meteorological Recorder (IMET) collected wind speed and wind direction, sea surface temperature, air temperature, short wave radiation, barometric pressure and relative humidity. The IMET also measured precipitation. The moorings were heavily instrumented below the surface with Vector Measuring Current Meters (VMCM) and single point temperature recorders. Expendable bathythermograph (XBT) data were collected and meteorological observations were made while transmitting between mooring locations. This report describes the work that took place during R/V Knorr cruise number 138 leg XV which was the fourth scheduled Subduction mooring cruise. During this cruise the moorings previously deployed for a third and final eight month period were recovered. This report includes a description of the moorings and instrumentation that were recovered, has information about the underway measurements (XBT and meteorological observations) that were made including plots of the data, and presents a chronology of the cruise events.Funding provided by the Office of Naval Research under Contract No. N00014-90-J-1490