Structure of Micro-instabilities in Tokamak Plasmas: Stiff Transport or Plasma Eruptions?

Solutions to a model 2D eigenmode equation describing micro-instabilities in tokamak plasmas are presented that demonstrate a sensitivity of the mode structure and stability to plasma profiles. In narrow regions of parameter space, with special plasma profiles, a maximally unstable mode is found that balloons on the outboard side of the tokamak. This corresponds to the conventional picture of a ballooning mode. However, for most profiles this mode cannot exist and instead a more stable mode is found that balloons closer to the top or bottom of the plasma. Good quantitative agreement with a 1D ballooning analysis is found provided the constraints associated with higher order profile effects, often neglected, are taken into account. A sudden transition from this general mode to the more unstable ballooning mode can occur for a critical flow shear, providing a candidate model for why some experiments observe small plasma eruptions (Edge Localised Modes, or ELMs) in place of large Type I ELMs.Comment: 11 pages, 3 figure

Test-retest reliability of time-frequency measures of auditory steady-state responses in patients with schizophrenia and healthy controls.

BackgroundAuditory steady-state response (ASSR) paradigms have consistently demonstrated gamma band abnormalities in schizophrenia at a 40-Hz driving frequency with both electroencephalography (EEG) and magnetoencephalography (MEG). Various time-frequency measures have been used to assess the 40-Hz ASSR, including evoked power, single trial total power, phase-locking factor (PLF), and phase-locking angle (PLA). While both EEG and MEG studies have shown power and PLF ASSR measures to exhibit excellent test-retest reliability in healthy adults, the reliability of these measures in patients with schizophrenia has not been determined.MethodsASSRs were obtained by recording EEG data during presentation of repeated 20-Hz, 30-Hz and 40-Hz auditory click trains from nine schizophrenia patients (SZ) and nine healthy controls (HC) tested on two occasions. Similar ASSR data were collected from a separate group of 30 HC on two to three test occasions. A subset of these HC subjects had EEG recordings during two tasks, passively listening and actively attending to click train stimuli. Evoked power, total power, PLF, and PLA were calculated following Morlet wavelet time-frequency decomposition of EEG data and test-retest generalizability (G) coefficients were calculated for each ASSR condition, time-frequency measure, and subject group.ResultsG-coefficients ranged from good to excellent (> 0.6) for most 40-Hz time-frequency measures and participant groups, whereas 20-Hz G-coefficients were much more variable. Importantly, test-retest reliability was excellent for the various 40-Hz ASSR measures in SZ, similar to reliabilities in HC. Active attention to click train stimuli modestly reduced G-coefficients in HC relative to the passive listening condition.DiscussionThe excellent test-retest reliability of 40-Hz ASSR measures replicates previous EEG and MEG studies. PLA, a relatively new time-frequency measure, was shown for the first time to have excellent reliability, comparable to power and PLF measures. Excellent reliability of 40 Hz ASSR measures in SZ supports their use in clinical trials and longitudinal observational studies

Aberrant activity in conceptual networks underlies N400 deficits and unusual thoughts in schizophrenia.

BackgroundThe N400 event-related potential (ERP) is triggered by meaningful stimuli that are incongruous, or unmatched, with their semantic context. Functional magnetic resonance imaging (fMRI) studies have identified brain regions activated by semantic incongruity, but their precise links to the N400 ERP are unclear. In schizophrenia (SZ), N400 amplitude reduction is thought to reflect overly broad associations in semantic networks, but the abnormalities in brain networks underlying deficient N400 remain unknown. We utilized joint independent component analysis (JICA) to link temporal patterns in ERPs to neuroanatomical patterns from fMRI and investigate relationships between N400 amplitude and neuroanatomical activation in SZ patients and healthy controls (HC).MethodsSZ patients (n = 24) and HC participants (n = 25) performed a picture-word matching task, in which words were either matched (APPLE→apple) by preceding pictures, or were unmatched by semantically related (in-category; IC, APPLE→lemon) or unrelated (out of category; OC, APPLE→cow) pictures, in separate ERP and fMRI sessions. A JICA "data fusion" analysis was conducted to identify the fMRI brain regions specifically associated with the ERP N400 component. SZ and HC loading weights were compared and correlations with clinical symptoms were assessed.ResultsJICA identified an ERP-fMRI "fused" component that captured the N400, with loading weights that were reduced in SZ. The JICA map for the IC condition showed peaks of activation in the cingulate, precuneus, bilateral temporal poles and cerebellum, whereas the JICA map from the OC condition was linked primarily to visual cortical activation and the left temporal pole. Among SZ patients, fMRI activity from the IC condition was inversely correlated with unusual thought content.ConclusionsThe neural networks associated with the N400 ERP response to semantic violations depends on conceptual relatedness. These findings are consistent with a distributed network underlying neural responses to semantic incongruity including unimodal visual areas as well as integrative, transmodal areas. Unusual thoughts in SZ may reflect impaired processing in transmodal hub regions such as the precuneus, leading to overly broad semantic associations

Observation of magnetocoriolis waves in a liquid metal Taylor-Couette experiment

The first observation of fast and slow magnetocoriolis (MC) waves in a laboratory experiment is reported. Rotating nonaxisymmetric modes arising from a magnetized turbulent Taylor-Couette flow of liquid metal are identified as the fast and slow MC waves by the dependence of the rotation frequency on the applied field strength. The observed slow MC wave is damped but the observation provides a means for predicting the onset of the Magnetorotational Instability

Malingering and the fraudulent motor insurance claimant

Malingering is the intentional production of false or grossly exaggerated symptoms in order to obtain an advantage. Although it has been estimated that over 800,000 claims for personal injury in Road Traffic Accidents (RTA) were filed in the UK in 2012, no approximation exists for how many involved malingering. This study attempts to understand what influences a psychiatrist to conclude that a claimant’s symptoms are not caused by an RTA and thus suggests the claimant is malingering. This article describes a study of Personality Assessment Inventory scores alongside collateral forms of evidence for 100 RTA claimants; all individuals seeking compensation for damages to their mental health. The results suggest that up to 40% of these claims could be categorised as not being the result of the RTA. Significant differences emerged between those claimants diagnosed as having a mental disorder as a result of the RTA and those claimants who were classified as not having a mental disorder as a result of the RTA in regards to: employment status, level of injuries and scores on the paranoia scales of the PAI. The study emphasises how the assessment process is idiosyncratic and in need of further research

Native title and Indigenous Australian utilisation of wildlife: Policy perspectives

The Native Title Act 1993 specifically recognises Indigenous property rights in Indigenous species; if there is one legislative event that could alter Indigenous utilisation of wildlife in the future it is provisions in this statute. This legal framework means that Indigenous people may in the future hold property or resource rights not just over currently vacant Crown land, but also in national parks or pastoral leasehold land. Some threshold legal issues, currently before the Federal Court, will clarify the significance of native title for Indigenous utilisation of wildlife. In this paper the use of wildlife by Indigenous Australians is assessed from an economic perspective using a standard production function framework in which output is determined by the variable combination of three input factors - land, labour and capital. The assessment shows that wildlife use for subsistence purposes is clearly of economic importance. Although inequalities exist in relation to the allocation of land between States, under the Native Title Act 1993 and the operations of the Indigenous Land Corporation it is possible there will be a significant increase in the amount of land owned or available for use by Indigenous people. This may not only increase access to wildlife resources and provide opportunities for Indigenous people to add to their incomes, but also add to the growing recognition of their ability and right to participate in environmental management. However, Indigenous people will need continuing access to cash to underwrite a subsistence lifestyle. Informed debate is needed to decide whether Indigenous use of wildlife is an economic option worth supporting and what benefits and costs might accrue from such facilitation both for Indigenous people and the wider Australian community

Observation of a Free-Shercliff-Layer Instability in Cylindrical Geometry

We report on observations of a free-Shercliff-layer instability in a Taylor-Couette experiment using a liquid metal over a wide range of Reynolds numbers, $Re\sim 10^3-10^6$. The free Shercliff layer is formed by imposing a sufficiently strong axial magnetic field across a pair of differentially rotating axial endcap rings. This layer is destabilized by a hydrodynamic Kelvin-Helmholtz-type instability, characterized by velocity fluctuations in the $r-\theta$ plane. The instability appears with an Elsasser number above unity, and saturates with an azimuthal mode number $m$ which increases with the Elsasser number. Measurements of the structure agree well with 2D global linear mode analyses and 3D global nonlinear simulations. These observations have implications for a range of rotating MHD systems in which similar shear layers may be produced.Comment: 5 pages, 4 figure

Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia

Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding contributes to symptoms and cognitive deficits, and this dysfunction is further posited to result from N-methyl-D-aspartate glutamate receptor (NMDAR) hypofunction. Previously, by examining auditory cortical responses to self-generated speech sounds, we demonstrated that predictive coding during vocalization is disrupted in schizophrenia. To test the hypothesized contribution of NMDAR hypofunction to this disruption, we examined the effects of the NMDAR antagonist, ketamine, on predictive coding during vocalization in healthy volunteers and compared them with the effects of schizophrenia. METHODS: In two separate studies, the N1 component of the event-related potential elicited by speech sounds during vocalization (talk) and passive playback (listen) were compared to assess the degree of N1 suppression during vocalization, a putative measure of auditory predictive coding. In the crossover study, 31 healthy volunteers completed two randomly ordered test days, a saline day and a ketamine day. Event-related potentials during the talk/listen task were obtained before infusion and during infusion on both days, and N1 amplitudes were compared across days. In the case-control study, N1 amplitudes from 34 schizophrenia patients and 33 healthy control volunteers were compared. RESULTS: N1 suppression to self-produced vocalizations was significantly and similarly diminished by ketamine (Cohen’s d = 1.14) and schizophrenia (Cohen’s d = .85). CONCLUSIONS: Disruption of NMDARs causes dysfunction in predictive coding during vocalization in a manner similar to the dysfunction observed in schizophrenia patients, consistent with the theorized contribution of NMDAR hypofunction to predictive coding deficits in schizophrenia.This work was supported by AstraZeneca for an investigator-initiated study (DHM) and the National Institute of Mental Health Grant Nos. R01 MH-58262 (to JMF) and T32 MH089920 (to NSK). JHK was supported by the Yale Center for Clinical Investigation Grant No. UL1RR024139 and the US National Institute on Alcohol Abuse and Alcoholism Grant No. P50AA012879. (AstraZeneca for an investigator-initiated study (DHM); R01 MH-58262 - National Institute of Mental Health; T32 MH089920 - National Institute of Mental Health; UL1RR024139 - Yale Center for Clinical Investigation; P50AA012879 - US National Institute on Alcohol Abuse and Alcoholism)Accepted manuscrip

Development of a theory of the spectral reflectance of minerals, part 2

Theory of diffuse reflectance of particulate media including garnet, glass, corundum powders, and mixture

Charge dependence of neoclassical and turbulent transport of light impurities on MAST

Carbon and nitrogen impurity transport coefficients are determined from gas puff experiments carried out during repeat L-mode discharges on the Mega-Amp Spherical Tokamak (MAST) and compared against a previous analysis of helium impurity transport on MAST. The impurity density profiles are measured on the low-field side of the plasma, therefore this paper focuses on light impurities where the impact of poloidal asymmetries on impurity transport is predicted to be negligible. A weak screening of carbon and nitrogen is found in the plasma core, whereas the helium density profile is peaked over the entire plasma radius.Comment: 17 pages, 7 figure