Pengembangan Media Pembelajaran Berbasis Event Logging Systems Untuk Analisis Perilaku Belajar Siswa

Pengembangan Media Pembelajaran Berbasis Event Logging Systems untuk Analisis PerilakuBelajar Siswa. Saat ini, banyak media pembelajaran menyediakan modul penting dengan memanfaatkanmultimedia. Namun, tantangan yang masih belum terpecahkan adalah suatu framework yangmengintegrasikan dua aspek, yaitu media pembelajaran berbasis multimedia dan system berbasis eventlogging untuk mencatat respon dan perilaku siswa. Sehingga, setiap kegiatan yang dilakukan oleh siswaakan dicatat oleh sistem, dan kemudian kita dapat menganalisis perilaku mereka berdasarkan data log yangbersifat obyektif dan akurat. Oleh karena itu, penelitian ini bertujuan untuk mengembangkan suatu platformyang menyediakan dua modul penting tersebut. Untuk menguji aplikasi ini, kami telah melakukanbeberapa eksperimen yang melibatkan siswa SMK di Bandung. Berdasarkan pengujian pada sistem ini,guru dapat mengetahui kecenderungan minat siswa terhadap suatu media pembelajaran. Di sisi lain, pesertadidik juga dapat memperoleh rekomendasi yang berguna, seperti apa jenis multimedia yang cocok (yaituberbasis teks, audio, video, dan ceramah)

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

Objective To evaluate the performance of diagnostic tools for diabetes mellitus, including laboratory methods and clinical risk scores, in newly-diagnosed pulmonary tuberculosis patients from four middle-income countries. Methods In a multicentre, prospective study, we recruited 2185 patients with pulmonary tuberculosis from sites in Indonesia, Peru, Romania and South Africa from January 2014 to September 2016. Using laboratory-measured glycated haemoglobin (HbA1c) as the gold standard, we measured the diagnostic accuracy of random plasma glucose, point-of-care HbA1c, fasting blood glucose, urine dipstick, published and newly derived diabetes mellitus risk scores and anthropometric measurements. We also analysed combinations of tests, including a two-step test using point-of-care HbA1cwhen initial random plasma glucose was ≥ 6.1 mmol/L. Findings The overall crude prevalence of diabetes mellitus among newly diagnosed tuberculosis patients was 283/2185 (13.0%; 95% confidence interval, CI: 11.6–14.4). The marker with the best diagnostic accuracy was point-of-care HbA1c (area under receiver operating characteristic curve: 0.81; 95% CI: 0.75–0.86). A risk score derived using age, point-of-care HbA1c and random plasma glucose had the best overall diagnostic accuracy (area under curve: 0.85; 95% CI: 0.81–0.90). There was substantial heterogeneity between sites for all markers, but the two-step combination test performed well in Indonesia and Peru. Conclusion Random plasma glucose followed by point-of-care HbA1c testing can accurately diagnose diabetes in tuberculosis patients, particularly those with substantial hyperglycaemia, while reducing the need for more expensive point-of-care HbA1c testing. Risk scores with or without biochemical data may be useful but require validation

Analisis Implikasi UU 35/2009 dan UU 36/2009 dalam Pengembangan Strategi Kebijakan Pencegahan dan Terapi Penyalahgunaan Narkotika Psikotropika dan Zat Adiktif (Napza) di Indonesia

Background: Substance use disorder is serious problem nationally and globally, although its controlling effort is more considered as criminal rather than health matters. This probably due to the tight regulation of the substance which make illegal use of it is considered as law violation. Commitment of Indonesian government is very strong by setting up aNational Narcotics Bureau (BNN as coordinating and implementing body on narcotics related activities, including therapy and rehabilitation. There are at least five ministries involved in narcotics related activities. However there is different level of the narcotics office in each ministries, reflected their prioirty. Narcotics laws No. 35/2009 provides MOH the right to receive report from therapy and rehabilitation institutions. However it is not clearly stated that MOH is the only resposible body for such report, which meant that Narcotics bureau could also receive the report from its district branches in provinces which previously under the Provincial office. This article reviews the implementation of Narcotics Law No. 35/2009 and Health Law No. 36/2009 for narcotic patients ini DKI, DIY, Jabar, Jatim dan Bali. Methods: The objective is to provide inputs for prevention and treatment policy development to stirr more sinergism and coordinated among related institution. Results: The review identified that narcotic Law UU 35/2009 stated Provincial Narcotic Bureau (BNP) as part of BNN, not part of provincial institution as it used to be. This imply that BNP could have power to regulate treatment and rehabilitation. Provinces need law regulation for coordination between BNP and other provincial institutions, such as health office. social affair office, primary health care and district/provincial hospitals. Health financing is the most important issue whtch need clear regulation because involving several stakeholders, such as ministry of health, BNN, governor and ministry of human affairs

Optimization of Vertical Well Placement for Oil Field Development Based on Basic Reservoir Rock Properties Using a Genetic Algorithm

Comparing the quality of basic reservoir rock properties is a common practice to locate new infill or development wells for optimizing oil field development using reservoir simulation. The conventional technique employs a manual trial-and-error process to find new well locations, which proves to be time-consuming, especially for large fields. Concerning this practical matter, an alternative in the form of a robust technique is introduced in order to reduce time and effort in finding new well locations capable of producing the highest oil recovery. The objective of this research was to apply a genetic algorithm (GA) for determining well locations using reservoir simulation, in order to avoid the conventional manual trial-and-error method. This GA involved the basic rock properties, i.e. porosity, permeability, and oil saturation, of each grid block obtained from a reservoir simulation model, to which a newly generated fitness function was applied, formulated by translating common engineering practice in reservoir simulation into a mathematical equation and then into a computer program. The maximum fitness value indicates the best grid location for a new well. In order to validate the proposed GA method and evaluate the performance of the program, two fields with different production profile characteristics were used, fields X and Y. The proposed method proved to be a robust and accurate method to find the best new well locations for oil field development. The key to the success of the proposed GA method lies in the formulation of the objective functions

Foreign bodies in the ears causing complications and requiring hospitalization in children 0-14 age: results from the ESFBI study

The occurrence of foreign bodies (FBs) in otorhinolaryngological practice is a common and serious problem among patients in paediatric age. The aim of this work is to characterize the risk of complications and prolonged hospitalization due to foreign bodies in ears in terms of the characteristics of the injured patients (age, gender), typology and features of the foreign bodies, the circumstances of the accident and the hospitalization's details

Text Mining the History of Medicine

Historical text archives constitute a rich and diverse source of information, which is becoming increasingly readily accessible, due to large-scale digitisation efforts. However, it can be difficult for researchers to explore and search such large volumes of data in an efficient manner. Text mining (TM) methods can help, through their ability to recognise various types of semantic information automatically, e.g., instances of concepts (places, medical conditions, drugs, etc.), synonyms/variant forms of concepts, and relationships holding between concepts (which drugs are used to treat which medical conditions, etc.). TM analysis allows search systems to incorporate functionality such as automatic suggestions of synonyms of user-entered query terms, exploration of different concepts mentioned within search results or isolation of documents in which concepts are related in specific ways. However, applying TM methods to historical text can be challenging, according to differences and evolutions in vocabulary, terminology, language structure and style, compared to more modern text. In this article, we present our efforts to overcome the various challenges faced in the semantic analysis of published historical medical text dating back to the mid 19th century. Firstly, we used evidence from diverse historical medical documents from different periods to develop new resources that provide accounts of the multiple, evolving ways in which concepts, their variants and relationships amongst them may be expressed. These resources were employed to support the development of a modular processing pipeline of TM tools for the robust detection of semantic information in historical medical documents with varying characteristics. We applied the pipeline to two large-scale medical document archives covering wide temporal ranges as the basis for the development of a publicly accessible semantically-oriented search system. The novel resources are available for research purposes, while the processing pipeline and its modules may be used and configured within the Argo TM platform

Can computer-aided diagnosis assist in the identification of prostate cancer on prostate MRI? a multi-center, multi-reader investigation.

For prostate cancer detection on prostate multiparametric MRI (mpMRI), the Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) and computer-aided diagnosis (CAD) systems aim to widely improve standardization across radiologists and centers. Our goal was to evaluate CAD assistance in prostate cancer detection compared with conventional mpMRI interpretation in a diverse dataset acquired from five institutions tested by nine readers of varying experience levels, in total representing 14 globally spread institutions. Index lesion sensitivities of mpMRI-alone were 79% (whole prostate (WP)), 84% (peripheral zone (PZ)), 71% (transition zone (TZ)), similar to CAD at 76% (WP, p=0.39), 77% (PZ, p=0.07), 79% (TZ, p=0.15). Greatest CAD benefit was in TZ for moderately-experienced readers at PI-RADSv2 <3 (84% vs mpMRI-alone 67%, p=0.055). Detection agreement was unchanged but CAD-assisted read times improved (4.6 vs 3.4 minutes, p<0.001). At PI-RADSv2 ≥ 3, CAD improved patient-level specificity (72%) compared to mpMRI-alone (45%, p<0.001). PI-RADSv2 and CAD-assisted mpMRI interpretations have similar sensitivities across multiple sites and readers while CAD has potential to improve specificity and moderately-experienced radiologists' detection of more difficult tumors in the center of the gland. The multi-institutional evidence provided is essential to future prostate MRI and CAD development

Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we present a complete sequence assembly of the germline genome and analyze multiple features of its structure and its relationship to the somatic genome, shedding light on the mechanisms of genome rearrangement as well as the evolutionary history of this remarkable germline/soma differentiation. Our results strengthen the notion that a complex, dynamic, and ongoing interplay between mobile DNA elements and the host genome have shaped Tetrahymena chromosome structure, locally and globally. Non-standard outcomes of rearrangement events, including the generation of short-lived somatic chromosomes and excision of DNA interrupting protein-coding regions, may represent novel forms of developmental gene regulation. We also compare Tetrahymenas germline/soma differentiation to that of other characterized ciliates, illustrating the wide diversity of adaptations that have occurred within this phylum.</p

Mutations causing medullary cystic kidney disease type 1 (MCKD1) lie in a large VNTR in MUC1 missed by massively parallel sequencing

While genetic lesions responsible for some Mendelian disorders can be rapidly discovered through massively parallel sequencing (MPS) of whole genomes or exomes, not all diseases readily yield to such efforts. We describe the illustrative case of the simple Mendelian disorder medullary cystic kidney disease type 1 (MCKD1), mapped more than a decade ago to a 2-Mb region on chromosome 1. Ultimately, only by cloning, capillary sequencing, and de novo assembly, we found that each of six MCKD1 families harbors an equivalent, but apparently independently arising, mutation in sequence dramatically underrepresented in MPS data: the insertion of a single C in one copy (but a different copy in each family) of the repeat unit comprising the extremely long (~1.5-5 kb), GC-rich (>80%), coding VNTR in the mucin 1 gene. The results provide a cautionary tale about the challenges in identifying genes responsible for Mendelian, let alone more complex, disorders through MPS

Mutations causing medullary cystic kidney disease type 1 (MCKD1) lie in a large VNTR in MUC1 missed by massively parallel sequencing

While genetic lesions responsible for some Mendelian disorders can be rapidly discovered through massively parallel sequencing (MPS) of whole genomes or exomes, not all diseases readily yield to such efforts. We describe the illustrative case of the simple Mendelian disorder medullary cystic kidney disease type 1 (MCKD1), mapped more than a decade ago to a 2-Mb region on chromosome 1. Ultimately, only by cloning, capillary sequencing, and de novo assembly, we found that each of six MCKD1 families harbors an equivalent, but apparently independently arising, mutation in sequence dramatically underrepresented in MPS data: the insertion of a single C in one copy (but a different copy in each family) of the repeat unit comprising the extremely long (~1.5-5 kb), GC-rich (>80%), coding VNTR in the mucin 1 gene. The results provide a cautionary tale about the challenges in identifying genes responsible for Mendelian, let alone more complex, disorders through MPS