A case of open angle glaucoma secondary to Posner-Schlossman Syndrome

This is a case report demonstrating appropriate diagnosis and management of PSS and its possible sequelae. Posner-Schlossman Syndrome is characterized by recurrent, unilateral attacks of significantly increased intraocular pressure. The etiology and pathophysiology of this condition remains unclear. Duration of this chronic condition and the risk of developing secondary open angle glaucoma are directly proportional. The patient and managing optometrist must be aware of the necessity of timely intervention during acute attacks, as well as adherent longitudinal care to preserve function and quality of life. The ensuing case report and review underscores the impact of this disease

Un cas de glaucome à angle ouvert consécutif au syndrome de Posner-Schlossman

Cette observation clinique présente le diagnostic et la prise en charge appropriés du syndrome de Posner-Schlossman (SPS) et de ses séquelles possibles. Le SPS se caractérise par des poussées unilatérales et récurrentes de pression intraoculaire fortement accrue. Bien que l’étiologie et la pathophysiologie de cette maladie chronique demeurent incertaines, sa durée est directement corrélée au risque de développer un glaucome secondaire à angle ouvert. Le patient et l’optométriste responsable doivent être conscients de la nécessité d’une intervention en temps opportun pendant les poussées aiguës, ainsi que du respect des soins longitudinaux pour préserver la fonction et la qualité de vie. Cette observation clinique et cet examen de cas soulignent l’impact de cette maladie

Visualisation Techniques For Facilitating Stakeholder Decision Making In Urban Planning

Public participatory geographical information systems (PPGIS) are becoming widely recognised as powerful tools for informed participatory decision-making processes within urban planning projects. This paper discusses a technique recently used within a case study for providing visualisations of traffic flows and how to incorporate local community perceptions of their neighbourhoods into a PPGIS software tool. In particular, the paper demonstrates a new methodology for visualisation of qualitative social data, facilitating dialogue and discussion amongst stakeholders and planning professionals in an urban context. The paper concludes with a discussion on techniques for developing software and presenting visualisations in an understandable and usable manner catering for a diversity of participants

ROVIBRATIONAL CHARACTERIZATION OF X2Σ+^{2}\Sigma^{+} 11^{11}BH+^{+} BY THE EXTRAPOLATION OF PHOTOSELECTED HIGH-RYDBERG SERIES IN 11^{11}BH

Author Institution: Department of Chemistry, Purdue University, West Lafayette, IN 47907; Department of Chemistry, University of British Columbia, 6174 University Boulevard,; Vancouver, BC, Canada V6T 1Z3Optical-optical-optical triple resonance spectroscopy of $^{11}$BH isolates high-Rydberg states that form series converging to rotational state specific ionization potentials in the vibrational levels of $^{11}$BH$^{+}$ from $v^{+} = 0$ through $4$. Limits defined by a comprehensive fit of these series to state-detailed thresholds yield rovibrational constants describing the X$^{2}\Sigma^{+}$ state of $^{11}$BH$^{+}$. The data provide a first determination of the vibration-rotation interaction parameter ${\alpha}_{e} = 0.4821$cm$^{-1}$ and a more accurate estimate of ${\omega}_{e} = 2526.58$cm$^{-1}$ together with the higher-order anharmonic terms ${\omega}_{e}x_{e} = 61.98$cm$^{-1}$ and ${\omega}_{e}y_{e} = -1.989$cm$^{-1}$. The deperturbation and global fit of series to state-detailed limits also yields a precise value of the adiabatic ionization potential of $^{11}$BH of $79120.3(1)$cm$^{-1}$, or $9.81033(1)$eV.$\;$ High precision is afforded here by the use of graphical analysis techniques, narrow bandwidth laser systems, and an analysis of newly observed, high-principal quantum number Rydberg states that conform well with a Hund's case (d) electron-core coupling limit

DYNAMICS OF DISSOCIATIVE RECOMBINATION, ELECTRON LOSS AND ISOLATED-CORE PHOTON ABSORPTION IN SINGLE ROVIBRONIC RYDBERG RESONANCES OF 11^{11}BH

Author Institution: Department of Chemistry, Purdue University, West Lafayette, IN 47907; Department of Chemistry, University of British Columbia, 6174 University Boulevard,; Vancouver, BC, Canada V6T 1Z3Optical-optical-optical triple resonance spectroscopy isolates transitions to vibrationless Rydberg states with principal quantum numbers from $n = 7$ to $50$ converging to the lowest ionization threshold of $^{11}$BH. These transitions appear in the excitation spectrum of photoionized B$^{*}$ atoms produced by dissociative relaxation of $^{11}$BH$^{*}$ Rydberg resonances. We observe a region in the spectra that shows evidence for further step of photoabsorption by the BH$^{+}$ core that leaves the quantum numbers of the Rydberg electron unchanged. For a certain range of third-photon excitation frequencies, a strongly allowed A$^{2}\Pi\leftarrow$X$^{2}\Sigma^{+}$ valence electronic absorption by the ion occurs, for which the initially prepared Rydberg electron acts as a spectator. Using a simple mathematical model in which we allow only transitions vertical in $n$, we show that the interval of $n$ for which this A$^{2}\Pi\rangle nl\rangle\leftarrow $X$^{2}\Sigma^{+}\rangle nl\rangle$ isolated-core excitation (ICE) rate exceeds that of the predissociation of $^{11}$BH$^{*}$ depends on the finite linewidths and positions of A$^{2}\Pi\rangle nl\rangle$ features and on the $n$-dependent predissociative lifetimes of $^{11}$BH$^{*}$ Rydberg molecules. Despite relatively broad resonance features, final states are found to decay slowly to neutral products, and, above threshold, where predissociation competes with direct ionization, the rate of electron loss exceeds neutral fragmentation by only an order of magnitude. Interference lineshapes observed for purely predissociative $v^{+} = 0$ Rydberg states match closely with states of the same principal quantum number built on $v^{+} = 1$, which yield only the ionic product, $^{11}$BH$^{+}$. We conclude that inelastic cation-electron interactions in $^{11}$BH proceed via coupling to a common continuum which gives rise to neutral and ionic products

Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes.

Changes in the microbiota composition are associated with many human diseases, but factors that govern strain abundance remain poorly defined. We show that a commensal Escherichia coli strain and a pathogenic Salmonella enterica serovar Typhimurium isolate both utilize nitrate for intestinal growth, but each accesses this resource in a distinct biogeographical niche. Commensal E. coli utilizes epithelial-derived nitrate, whereas nitrate in the niche occupied by S. Typhimurium is derived from phagocytic infiltrates. Surprisingly, avirulent S. Typhimurium was shown to be unable to utilize epithelial-derived nitrate because its chemotaxis receptors McpB and McpC exclude the pathogen from the niche occupied by E. coli. In contrast, E. coli invades the niche constructed by S. Typhimurium virulence factors and confers colonization resistance by competing for nitrate. Thus, nutrient niches are not defined solely by critical resources, but they can be further subdivided biogeographically within the host into distinct microhabitats, thereby generating new niche opportunities for distinct bacterial species

Evidence for an association between heat shock protein 70 and the respiratory syncytial virus polymerase complex within lipid-raft membranes during virus infection

AbstractIn this report, the interaction between respiratory syncytial virus (RSV) and heat shock protein 70 (HSP70) was examined. Although no significant increase in total HSP70 protein levels was observed during virus infection, analysis of the HSP70 content in lipid-raft membranes from mock- and virus-infected cells revealed an increase in the levels of raft-associated HSP70 during virus infection. Fluorescence microscopy demonstrated that this transport of HSP70 into lipid-raft membranes correlated with the appearance of HSP70 within virus-induced inclusion bodies. Furthermore, co-localisation of HSP70 with the virus N protein and the raft lipid GM1 was observed within these structures. Immunoprecipitation experiments demonstrated the ability of HSP70 to interact with the virus polymerase complex in lipid-rafts in an ATP-dependent manner. Collectively, these data suggest that RSV may induce cellular changes which allow the recruitment of specific host-cell factors, via lipid-raft membranes, to the polymerase complex

The PLATO Mission

International audiencePLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases