Diavideos: a Diabetes Health Video Portal

Diavideos1 is a web platform that collects trustworthy diabetes health videos from YouTube and offers them in a easy way. YouTube is a big repository of health videos, but good content is sometimes mixed with misleading and harmful videos such as promoting anorexia [1].Diavideos is a web portal that provides easy access to a repository of trustworthy diabetes videos. This poster describes Diavideos and explains the crawling method used to retrieve these videos from trusted channels

N-Doped Cationic PAHs by Rh(III)-Catalyzed Double C–H Activation and Annulation of 2-Arylbenzimidazoles with Alkynes

NOTICE: This is the peer reviewed version of the following article: Villar, J. M., Suárez, J., Varela, J. A., Saá, C., (2017). N-Doped Cationic PAHs by Rh(III)-Catalyzed Double C–H Activation and Annulation of 2-Arylbenzimidazoles with Alkynes. Org. Lett. 19, 7, 1702-1705. [doi: 10.1021/acs.orglett.7b00478]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archivingA novel class of N-doped cationic PAHs (Polycyclic Aromatic Hydrocarbons) bearing the benzo[c,d]fluoranthene scaffold has been synthesized by the Rh(III)-catalyzed double oxidative annulation of 2-arylbenzimidazoles with alkynes. The overall process involves a double C–N bond formation through a double C–H/N–H functionalization.The solid-state structures and electronic properties of the new N-doped PAHs were analyzed. These cationic azapolycycles were readily reduced in the presence of LiAlH4 or by the addition of PhLi to give interesting phenyl and diphenylmethanediamine derivatives.This work has received financial support from Spanish MINECO (project CTQ2014-59015R), the Consellería de Cultura, Educación e Ordenación Universitaria (project GRC2014/032) and Centro singu-lar de investigación de Galicia, accreditation 2016-2019, ED431G/09 and ERDF. We also thank the ORFEO-CINQA network (CTQ2014-51912REDC). J.M. V. and J. S. thank the Xunta de Galicia for pre-doctoral and postdoctoral contracts, respectivelyS

Houston and climate urgency as a model of infrastructural conflict : the paradigmatic case of Harrisburg-Manchester neighbourhood

Houston es, a día de hoy, el lugar donde más claramente se están dejando ver los estragos del desequilibrio ambiental al que estamos sometiendo el planeta. Las inundaciones y heladas del pasado invierno así lo constatan. Sin embargo, se dan en la ciudad una serie de variables y agentes involucrados que tienen que ver con las desigualdades sociales, la cultura del petróleo o las comunidades racializadas. Harrisburg-Manchester es uno de los barrios donde estos conflictos se han intensificado desde los años cincuenta con la colonización del borde del canal por parte de la industria de refinería de petróleo. Esta investigación pretende demostrar cómo el problema que afecta a esta comunidad funciona como un modelo de conflicto infraestructural global extrapolable a otros escenarios por venir en diferentes países. Mediante el uso del dibujo arquitectónico y técnicas de representación de infraestructuras con un carácter especulativo, el trabajo pretende dar visibilidad al conjunto de actores involucrados en el conflicto, revelando una trascendencia más allá de lo local y convirtiendo el asunto en un problema transescalar. El dibujo a través de ortofotos históricas nos permite representar por años la ocupación y opresión del territorio de una comunidad hispana no blanca por parte de la industria del petróleo encabezada por Valero Corp. Por otra parte, una serie de dibujos de infraestructuras nos permiten leer el conflicto trascendiendo la forma construida de los agentes contaminantes y visibilizando el verdadero alcance de los medios climáticos que están siendo transformados: el aire y el agua. Se consigue, de esta manera, ampliar el espectro de soportes infraestructurales, normalmente copado por actores tradicionales (industria, vehículos a motor o tráfico marítimo), poniendo el foco sobre todo en el papel del agua y el aire de la ciudad como responsables de fuertes movilizaciones de partículas contaminadas. Se pone de manifiesto la posibilidad de no seguir generando solamente infraestructuras activas o resilientes contra el clima (zonas inundables o estanques de tormentas) sino generar políticas y sistemas que tengan al agua y el aire de las ciudades como agentes protagonistas que al ser modificados y controlados pueden ser determinantes sobre el alcance de los efectos del clima sobre las ciudades.Houston is currently the place where the damage caused by the environmental imbalance to which we are subjecting the planet is most clearly visible. The floods and frosts of last winter demonstrate such a situation. However, there are a series of variables and agents involved in the city that have to do with social inequalities, the oil culture or racialized communities. Harrisburg-Manchester is one of the neighborhoods where these conflicts have intensified since the 1950s with the colonisation of the canal's edge by the oil refining industry. This research aims to illustrate how the problem affecting this community functions as a model of global infrastructural conflict that can be extrapolated to other upcoming scenarios in different countries. Through the use of architectural drawing and infrastructural representation techniques with a speculative character, the work aims to give visibility to the set of actors involved in the conflict, revealing a transcendence beyond the local and turning the issue into a trans-scalar problem. Drawing through historical orthophotos allows us to represent for years the occupation and oppression of the territory of a non-white Hispanic community by the oil industry headed by Valero Corp. On the other hand, a series of drawings of infrastructures allow us to read the conflict transcending the constructed form of polluting agents and making visible the true scope of the climatic media that are being transformed: air and water. In this way, the spectrum of infrastructural support, normally dominated by traditional actors (industry, motor vehicles or maritime traffic), is broadened, putting the focus on the role of water and city air as responsible for strong movements of polluted particles. It highlights the possibility of no longer generating only active or climate-resilient infrastructures (flood zones or storm ponds), but of generating policies and systems in which the water and air of cities are key players which, when modified and controlled, can determine the extent of the effects of climate on cities

Tandem Long Distance Chain-Walking/Cyclization via RuH2(CO)(PPh3)3/Brønsted Acid Catalysis: Entry to Aromatic Oxazaheterocycles

NOTICE: This is the peer reviewed version of the following article: Bernárdez, R., Suárez, J., Fañanás-Mastral, M., Varela, J. A., Saá, C. (2016). Tandem Long Distance Chain-Walking/Cyclization via RuH2(CO)(PPh3)3/Brønsted Acid Catalysis: Entry to Aromatic Oxazaheterocycles. Org. Lett., 18, 4, 642-645. [doi: 10.1021/acs.orglett.5b03499]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving.A novel route to 1,3-oxazaheterocycles based on cooperative Ru–H/Brønsted acid catalysis is reported. The use of the commercially available RuH2(CO)(PPh3)3 complex allows for an efficient long distance chain-walking process while the Brønsted acid is responsible for generation of an electrophilic iminium ion which is trapped intramolecularly by an alcohol moiety. The alcohol, besides its nucleophilic function, also plays an important role in the stabilization of the Ru catalyst.This work was supported by MINECO (Spain) (projects CTQ2011-28258 and CTQ2014-59015R), Xunta de Galicia (project GRC2014/032) and the European Regional Development Fund (projects CTQ2014-59015R and GRC2014/032). R. B. thanks MEC for a predoctoral FPU fellowship and J. S. thanks XUGA for a postdoctoral contract. M. F.-M. thanks MINECO for a "Ramón y Cajal" contractS

Rh(III)-Catalyzed [5+2] Oxidative Annulation of Cyclic Arylguanidines and Alkynes to 1,3-Benzodiazepines. A Striking Mechanistic Proposal from DFT

NOTICE: This is the peer reviewed version of the following article: Martínez-Yáñez, N., Suárez, J., Cajaraville, A., Varela, J. A., Saá, C. (2019). Rh(III)-Catalyzed [5+2] Oxidative Annulation of Cyclic Arylguanidines and Alkynes to 1,3-Benzodiazepines. A Striking Mechanistic Proposal from DFT. Org. Lett. 21, 6, 1779-1783. [doi: 10.1021/acs.orglett.9b00354]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archivingA novel and mild Rh(III)-catalyzed [5+2] oxidative annulation between cyclic arylguanidines and alkynes efficiently affords 1,3-benzodiazepines (pentacyclic guanidines). The use of O2 as the sole oxidant in place commonly used metal oxidants such as AgOAc clearly improves the efficiency of the oxidative annulation process. The mechanism of the cycloaddition most likely involves the formation of an eight-membered rhodacycle. DFT calculations support a striking mechanistic proposal for the [5+2] oxidative annulation.This work has received financial support from MINECO (projects CTQ2014-59015R, CTQ2017-87939R and ORFEO-CINQA network CTQ2016-81797-REDC), the Xunta de Galicia (project GRC2014/032, ED431C 2018/04 and Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09) and the European Union (European Regional Development Fund - ERDF). N. M.-Y. thanks MINECO and Xunta de Galicia for a predoctoral contractS

Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines

NOTICE: This is the peer reviewed version of the following article: Cajaraville, A., Suárez, J., López, S., Varela. J. A., Saá, C. (2015). Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines. Chem. Commun., 51, 82, 15157-15160. [doi: 10.1039/C5CC06388D]. This article may be used for non-commercial purposes in accordance with The Royal Society of Chemistry Terms and Conditions for self-archivingA novel and mild RhIII-catalyzed [5+1] oxidative cycloaddition between arylguanidines and alkynes efficiently affords C4-disubstituted 1,4-dihydroquinazolin-2-amines. Members of this family of heterocycles, which contain the relevant cyclic guanidine units, have shown interesting pharmacological properties. The mechanism probably involves the formation of an eight-membered rhodacycle in which the imine unit of guanidine is coordinated to the Rh center. This rhodacycle would evolve to give the C-4 disubstituted 1,4-dihydroquinazolin-2-amine skeleton.This work was supported by MICINN (project CTQ2011‐28258), Xunta de Galicia and European Regional Development Fund (projects GRC2014/032 and EM 2012/051). A. C. and J. S. thank Spanish MICINN and Xunta de Galicia for a predoctoral FPI fellowship and postdoctoral contract, respectivelyS