Centro cultural El Cabañal

Centro cultural en el CabanyalRivero Cantillano, FA. (2011). Centro cultural El Cabañal. http://hdl.handle.net/10251/36650.Archivo delegad

Nociones sobre la detección temprana del autismo en profesionales de enfermería de la Microred de salud Lambayeque, 2022

La detección del autismo por parte del profesional de enfermería permite la intervención temprana del trastorno del espectro autista, disminuyendo su sintomatología que presenta el niño con autismo. Método: Investigación cualitativa, con abordaje descriptivo. Objetivo: Describir las nociones sobre la detección temprana del autismo en profesionales de enfermería en la Microred de salud Lambayeque, 2022. Muestra: 12 profesionales de enfermería que laboran en el servicio integral del niño de la Microred de salud Lambayeque; el muestreo fue no probabilístico por conveniencia, con criterios de inclusión y exclusión, los datos se recolectaron mediante una guía de entrevista semiestructurada, validada por juicio de expertos y prueba piloto previa aprobación del comité de ética, el análisis fue de contenido; se cumplió con los principios de rigor ético y científico. Se obtuvieron 4 categorías: (1) Nociones relacionadas con la detección del autismo desde la atención primaria de salud, (2) Conceptualizando el autismo desde los saberes de los profesionales de enfermería, (3) Reconociendo el rol que deben tener los profesionales de enfermería en la detección precoz del autismo, (4) Necesidad de incluir el autismo en la formación académica, educacióncontinua y planes de capacitación del profesional de enfermería. Conclusiones: Los conocimientos del profesional de enfermería sobre el autismo son superficiales, al parecer el autismo resulta en nuestro medio un trastorno en general poco conocido.The detection of autism by the nursing professional allows early intervention of autism spectrum disorder, reducing the symptoms presented by the child with autism. Method: Qualitative research, with a descriptive approach. Objective: Describe the notions about the early detection of autism in nursing professionals in the Lambayeque Health Micronetwork, 2022. Sample: 12 nursing professionals who work in the comprehensive child service of the Lambayeque Health Micronetwork; The sampling was non-probabilistic for convenience, with inclusion and exclusion criteria, the data were collected using a semi-structured interview guide, validated by expert judgment and pilot testing prior approval of the ethics committee, the analysis was content; The principles of ethical and scientific rigor were complied with. 4 categories were obtained: (1) Notions related to the detection of autism from primary health care, (2) Conceptualizing autism from the knowledge of nursing professionals, (3) Recognizing the role that nursing professionals should have in early detection of autism, (4) Need to include autism in the academic training, continuing education and training plans of nursing professionals. Conclusions: The knowledge of the nursing professional about autism is superficial; it seems that autism is a generally little- known disorder in our environment

Estudio de prefactibilidad para la instalación de una planta ensambladora de scooters eléctricos

El tráfico vehicular es un fenómeno que va en aumento día a día, este comportamiento permitió ofrecer un producto que brinde tiempos de traslado menores que el de un automóvil y encontrar un mercado objetivo en Lima Metropolitana. El producto en estudio es un scooter eléctrico con implementos de seguridad y una bolsa frontal para trasladar artículos del día a día. En primer lugar, se ha descrito el producto en sus tres niveles; y las políticas de comercialización, precio y distribución. Luego, se ha utilizado data histórica, DIA, resultados de la encuesta (intención e intensidad de compra) y la segmentación para el mercado objetivo para determinar la demanda del proyecto, es decir, 2 862 scooters al 2025 a un precio unitario de S/ 2 299,00. Después, resultó que la macro localización de la planta será en Lima y la micro localización en el distrito de Lurín. Asimismo, el tamaño de la planta será igual a la demanda del proyecto ya que no existen limitantes por materia prima, tecnología ni punto de equilibrio. El área total de la empresa, incluyendo producción y administración, es de 209 m2 , siendo un total de 13 trabajadores en planilla, 8 administrativos y 5 en producción. Se desarrolló la ingeniería del producto en la cual se detallan las especificaciones técnicas del mismo, el balance de línea para determinar la cantidad de estaciones, las características de la maquinaria a utilizar, la cantidad de operarios y las dimensiones de la planta, tanto para la zona de producción como para la zona administrativa. Finalmente, se desarrolló un análisis económico que dio como resultado un VANE de S/ 425 353, TIRE de 21,8% y un B/C de 1,30. Mientras que por el lado financiero se obtuvo como resultado un VANF de S/ 562 894, TIRF de 32,8% y un B/C de 1,96; y se determinó que las variables más sensibles son demanda y precio, pues están directamente relacionadas a la rentabilidad del proyecto.Every day, traffic is having a daily increase. This trend allows to offer a product with less time of transportation than using a car, observing that there is an opportunity to focus in an objective maket in Lima Metropolitana. The study product in mention is an electric scooter with safety accesories and a front bag to carry daily articles like keys, cell phones, wallets, etc. First, levels of product were described; and marketing, pricing, and distribution policies were detailed. Then, historic data of imports, survey results, and a market study were combined to obtain a demand for 2 862 electric scooters for the year 2025, which will be offered with a sales price of S/ 2 299,00. A location study was conduced and the optimal result for the project is: department of Lima and district of Lurin. In regards to plant size, it will be market size because there is not a raw material, technology and equal point restriction. The total area of the plant, including production and administration, is 209 square meters; with eight and five employees per area respectively. Product engineering was develop, which included specifications, line balance to obtain quantity of stalls, machinery features, number of production employees, and plant dimensions. Furthermore, economic and financial evaluation were analyzed to confirm if the project is profitable using the following indicators: an economic NPV of S/ 425 353, IRR of 21,8%, and B/C of 1,30; and financial NPV of S/ 562 894, IRR of 32,8%, and B/C of 1,96. Finally, demand and price are the most sensitive variables of the project because an increase in one of them will represent a better profit

Social vulnerability to climatic shocks is shaped by urban accessibility

Despite growing interest in urban vulnerability to climatic change, there is no systematic understanding of why some urban centers have greater social vulnerability than others. In this article, we ask whether the social vulnerability of Amazonian cities to floods and droughts is linked to differences in their spatial accessibility. To assess the accessibility of 310 urban centers, we developed a travel network and derived measures of connectivity and geographical remoteness. We found that 914,654 people live in roadless urban centers (n = 68) located up to 2,820km from their state capital. We then tested whether accessibility measures explained interurban differences in quantitative measures of social sensitivity, adaptive capacity, and an overlooked risk area, food system sensitivity. Accessibility explained marked variation in indicators of each of these dimensions and, hence, for the first time, we show an underlying spatial basis for social vulnerability. For instance, floods pose a greater disease risk in less accessible urban centers because inadequate sanitation in these places exposes inhabitants to environmental pollution and contaminated water, exacerbated by poverty and governance failures. Exploring the root causes of these spatial inequalities, we show how remote and roadless cities in Amazonia have been historically marginalized and their citizens exposed to structural violence and economic disadvantage. Paradoxically, we found that places with the highest social vulnerability have the greatest natural and cultural assets (rainforest, indigenous peoples, and protected areas). We conclude that increasing accessibility through road building would be maladaptive, exposing marginalized people to further harm and exacerbating climatic change by driving deforestation

Narcissistic Self-Sorting of n-Acene Nano-Ribbons yielding Energy-Transfer and Electroluminescence at p-n Junctions

The 2,3-didecyloxy-derivative of an n-type anthracene (n-BG) and a p-type tetracene (p-R) have been synthesized and their self-assembly into nano-ribbons studied. Hyperspectral fluorescence imaging revealed their narcissistic self-sorting, leading to separated nanoribbons emitting with very different colors (blue or green for n-BG, depending on the growth solvent, and red for p-R). It is unique that the usual origins of self-sorting, such as specific H-bonding, different growth kinetics, or incompatible steric hindrance can be ruled out. Hence, the narcissistic behaviour is herein proposed to originate from a sofar unconsidered cause: the discrepancy between the quadrupolar character of n-BG and dipolar character of p-R. At the pn-junctions of these nanoribbons, inter-ribbon FRET and electro-luminescence switch-on were observed by fluorescence microscopy.Modulation of Organic Optic Information InterfacesFabrication Supramoléculaire de Dispositifs OLED Haute Résolution par voie ImprimableSoft Materials Advanced Research Training Networ

Narcissistic self-sorting of n-acene nano-ribbons yielding energy-transfer and electroluminescence at p–n junctions

The 2,3-didecyloxy derivative of an n-type anthracene (n-BG) and a p-type tetracene (p-R) have been synthesized and their self-assembly into nano-ribbons studied. Hyperspectral fluorescence imaging revealed their narcissistic self-sorting, leading to separated nanoribbons emitting with very different colors (blue or green for n-BG, depending on the growth solvent, and red for p-R). It is unique that the usual origins of self-sorting, such as specific H-bonding, different growth kinetics, or incompatible steric hindrance can be ruled out. Hence, the narcissistic behaviour is herein proposed to originate from a so-far unconsidered cause: the discrepancy between the quadrupolar character of n-BG and dipolar character of p-R. At the p–n junctions of these nanoribbons, inter-ribbon FRET and electro-luminescence switch-on were observed by fluorescence/luminescence microscopy.Fabrication Supramoléculaire de Dispositifs OLED Haute Résolution par voie ImprimableModulation of Organic Optic Information Interface

A systematic review and meta-analysis of artificial intelligence diagnostic accuracy in prostate cancer histology identification and grading

[Background] Artificial intelligence (AI) is a promising tool in pathology, including cancer diagnosis, subtyping, grading, and prognostic prediction.[Methods] The aim of the study is to assess AI application in prostate cancer (PCa) histology. We carried out a systematic literature search in 3 databases. Primary outcome was AI accuracy in differentiating between PCa and benign hyperplasia. Secondary outcomes were AI accuracy in determining Gleason grade and agreement among AI and pathologists.[Results] Our final sample consists of 24 studies conducted from 2007 to 2021. They aggregate data from roughly 8000 cases of prostate biopsy and 458 cases of radical prostatectomy (RP). Sensitivity for PCa diagnostic exceeded 90% and ranged from 87% to 100%, and specificity varied from 68% to 99%. Overall accuracy ranged from 83.7% to 98.3% with AUC reaching 0.99. The meta-analysis using the Mantel-Haenszel method showed pooled sensitivity of 0.96 with I2 = 80.7% and pooled specificity of 0.95 with I2 = 86.1%. Pooled positive likehood ratio was 15.3 with I2 = 87.3% and negative – was 0.04 with I2 = 78.6%. SROC (symmetric receiver operating characteristics) curve represents AUC = 0.99. For grading the accuracy of AI was lower: sensitivity for Gleason grading ranged from 77% to 87%, and specificity from 82% to 90%.[Conclusions] The accuracy of AI for PCa identification and grading is comparable to expert pathologists. This is a promising approach which has several possible clinical applications resulting in expedite and optimize pathology reports. AI introduction into common practice may be limited by difficult and time-consuming convolutional neural network training and tuning.Peer reviewe

ENIGMA-anxiety working group : Rationale for and organization of large-scale neuroimaging studies of anxiety disorders

Altres ajuts: Anxiety Disorders Research Network European College of Neuropsychopharmacology; Claude Leon Postdoctoral Fellowship; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 44541416-TRR58); EU7th Frame Work Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw, 10-000-1002); Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, MH002781); National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, ZIA-MH-002782); SA Medical Research Council; U.S. National Institutes of Health grants (P01 AG026572, P01 AG055367, P41 EB015922, R01 AG060610, R56 AG058854, RF1 AG051710, U54 EB020403).Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders