Diseño y avalúo de campañas de educación ambiental: El caso de la Cuenca hidrográfica del Río Grande de Añasco

Tanto la literatura académica, como el discurso público, promueven los proyectos de educación ambiental como fundamentales para el manejo sustentable de los recursos. Usualmente se entiende que generan comportamientos conservacionistas (“best management practices”) en la comunidad y aumentan la participación ciudadana en los procesos de toma de decisiones ambientales (por ejemplo, vistas públicas). Sin embargo, a pesar de que los proyectos de educación ambiental se han multiplicado en las últimas décadas, el estado de recursos clave, como el agua, ha ido en constante deterioro, tanto en Puerto Rico, como en el mundo. Este artículo propone que deficiencias en el diseño, implementación y avalúo de las campañas educativas influyen directamente en su efectividad. A través de la descripción del proceso de diseño, producción y avalúo de una campaña de educación y concienciación sobre la cuenca hidrográfica del Río Grande de Añasco, Puerto Rico, proveemos un modelo que ha probado ser exitoso para la creación, desarrollo, implementación y prueba de campañas de educación ambiental

Leucemia linfocítica crónica / Linfoma linfocítico de células pequeñas.

Los linfomas son neoplasias malignas derivadas del tejido linfoide que clásicamente se clasifican en dos grandes grupos: Los linfomas de Hodgkin (LH) y los linfomas no Hodgkin (LNH); estos últimos pueden tener una presentación a nivel ganglionar o bien extraganglionar (piel, tubo digestivo, cerebro, etc.). Cuando existe involucro de la médula ósea se consideran como leucemias.Recientemente (2008), la OMS publicó en su cuarta edición la Clasificación de los Tumores de Tejido Hematopoyético y Linfoide basándose en los aspectos morfológicos, inmunofenotipo, hallazgos genéticos y clínicos para definir la enfermedad. Entre otras categorías, las neoplasias linfoides pueden ser derivadas de células precursoras, neoplasias de células B maduras, neoplasias de células T maduras y de células NK para los LNH. 1Se reporta un caso clínico con linfoma linfocitico de células pequeñas (SLL) (un tipo de linfoma no Hodgkin), valorado en el Hospital General Dr. Darío Fernández Fierro. ISSSTE

New dating of the Matalascañas footprints provides new evidence of the Middle Pleistocene (MIS 9-8) hominin paleoecology in southern Europe

Hominin footprints were recently discovered at Matalascanas (Huelva; South of Iberian Peninsula). They were dated thanks to a previous study in deposits of the Asperillo cliff to 106 +/- 19 ka, Upper Pleistocene, making Neandertals the most likely track-makers. In this paper, we report new Optically Stimulated Luminescence dating that places the hominin footprints surface in the range of 295.8 +/- 17 ka (MIS 9-MIS 8 transition, Middle Pleistocene). This new age implies that the possible track-makers are individuals more likely from the Neandertal evolutionary lineage. Regardless of the taxon attributed to the Matalascanas footprints, they supplement the existing partial fossil record for the European Middle Pleistocene Hominins being notably the first palaeoanthropological evidence (hominin skeleton or footprints) from the MIS 9 and MIS 8 transition discovered in the Iberian Peninsula, a moment of climatic evolution from warm to cool. Thus, the Matalascanas footprints represent a crucial record for understanding human occupations in Europe in the Pleistocene.We thank the Territorial Delegation in Huelva of the Ministry of Agriculture, Livestock, Fisheries and Sustainable Development of the Junta de Andalucia for permission to conduct research. Furthermore, this work has been financial support from the Ministry of Science and Innovation of Spain (grant no. PID2019-104625RB-100), the Andalusian Government to the Research Group RNM276 and Basque Government to the Research Group EJ IT1418-19. In addition, AGO is supported by a Ramon y Cajal fellowship (RYC-2017-22558) and by the Ministry of Science and Innovation of Spain (grant no. PGC2018-093925-B-C33, MCI/AEI/FEDER, UE). We would also like to give special thanks to Alicia Medialdea Utande, Head of the Luminescence Research Line of the National Center for Research on Human Evolution-CENIEH, for her help and collaboration in the treatment and interpretation of the data

Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up

[Background and objective] Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it.[Patients and Methods] PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls.[Results] The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716).[Conclusions] Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.Martínez-Martin P. has received honoraria from National School of Public Health (ISCIII), Editori-al Viguera and Takeda Pharmaceuticals for lecturing in courses, and from the International Parkinson and Movement Disorder Society (MDS) for management of the Program on Rating Scales. Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB, and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575], co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [ PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.Peer reviewe

Memorias del Seminario, el lenguaje en la ciencia y en la educación

La práctica educativa es en esencia una práctica social que se realiza a través de la comunicación y, como tal, compete a todos los actores involucrados en el proceso educativo (maestros, alumnos, padres, comunidad educativa). / Contenido. Preliminares; Capítulo 1 - Hacia la construcción de una concepción de lenguaje; Capítulo 2 - Lenguaje y conocimiento científico; Capítulo 3 - Lenguaje, literatura y educación; Capítulo 4 - Códigos sociolingüísticos y procesos de enseñanza - aprendizaje; Capítulo 5 - Planeación hablada y escritura; Capítulo 6 - La escritura como proceso: una propuesta didáctica para que los estudiantes de bachillerato escriban; Capítulo 7 - De lo conocido a lo desconocido: una estrategia de aprendizaje para comprender y producir textos en el aula, desde una perspectiva teórica de Teun Van Dijk; Capítulo 8 - Textualidad literaria y saberes: actualización de un texto de Borges en el aula; Capítulo 9 - Los procesos de lecto-ecritura desde las ciencias del lenguaje; Capítulo 10 - El desarrollo de la competencia comunicativa en los procesos lecto-escriturales; Capítulo 11 - La informática como recurso de integración de las disciplinas, a través de procesos textuales; Capítulo 12 - Ponencia de la escuela distrital rural Los Soches; Anexos

Staging Parkinson’s disease according to the MNCD classification correlates with caregiver burden

Malaltia de Parkinson; Cuidador; Símptomes no motorsParkinson's disease; Caregiver; Non-motor symptomsEnfermedad de Parkinson; Cuidador; Síntomas no motoresBackground and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status. Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Two hundred and twenty-four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers.Conclusion: Staging PD according to the MNCD classification is correlated with caregivers’ strain and burden.Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético; Alpha Bioresearch; Spanish Ministry of Economy and Competitiveness, Grant/Award Number: PI16/0157

The ALMA-CRISTAL survey: Widespread dust-obscured star formation in typical star-forming galaxies at z=4-6

We present the morphological parameters and global properties of dust-obscured star formation in typical star-forming galaxies at z=4-6. Among 26 galaxies composed of 20 galaxies observed by the Cycle-8 ALMA Large Program, CRISTAL, and six galaxies from archival data, we have individually detected rest-frame 158$\mu$m dust continuum emission from 19 galaxies, nine of which are reported for the first time. The derived far-infrared luminosities are in the range $\log_{10} L_{\rm IR}\,[L_{\odot}]=$10.9-12.4, an order of magnitude lower than previously detected massive dusty star-forming galaxies (DSFGs). The average relationship between the fraction of dust-obscured star formation ($f_{\rm obs}$) and the stellar mass is consistent with previous results at z=4-6 in a mass range of $\log_{10} M_{\ast}\,[M_{\odot}]\sim$9.5-11.0 and show potential evolution from z=6-9. The individual $f_{\rm obs}$ exhibits a significant diversity, and it shows a correlation with the spatial offset between the dust and the UV continuum, suggesting the inhomogeneous dust reddening may cause the source-to-source scatter in $f_{\rm obs}$. The effective radii of the dust emission are on average $\sim$1.5 kpc and are $\sim2$ times more extended than the rest-frame UV. The infrared surface densities of these galaxies ($\Sigma_{\rm IR}\sim2.0\times10^{10}\,L_{\odot}\,{\rm kpc}^{-2}$) are one order of magnitude lower than those of DSFGs that host compact central starbursts. On the basis of the comparable contribution of dust-obscured and dust-unobscured star formation along with their similar spatial extent, we suggest that typical star-forming galaxies at z=4-6 form stars throughout the entirety of their disks

In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson’s disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r =0.37, p <0.001), and this association remained significant after controlling for several potential confounding variables (p =0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p =0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition- relevant changes in non-demented PD