The gastrointestinal electrical mapping suite (GEMS): software for analyzing and visualizing high-resolution (multi-electrode) recordings in spatiotemporal detail

BACKGROUND: Gastrointestinal contractions are controlled by an underlying bioelectrical activity. High-resolution spatiotemporal electrical mapping has become an important advance for investigating gastrointestinal electrical behaviors in health and motility disorders. However, research progress has been constrained by the low efficiency of the data analysis tasks. This work introduces a new efficient software package: GEMS (Gastrointestinal Electrical Mapping Suite), for analyzing and visualizing high-resolution multi-electrode gastrointestinal mapping data in spatiotemporal detail. RESULTS: GEMS incorporates a number of new and previously validated automated analytical and visualization methods into a coherent framework coupled to an intuitive and user-friendly graphical user interface. GEMS is implemented using MATLAB®, which combines sophisticated mathematical operations and GUI compatibility. Recorded slow wave data can be filtered via a range of inbuilt techniques, efficiently analyzed via automated event-detection and cycle clustering algorithms, and high quality isochronal activation maps, velocity field maps, amplitude maps, frequency (time interval) maps and data animations can be rapidly generated. Normal and dysrhythmic activities can be analyzed, including initiation and conduction abnormalities. The software is distributed free to academics via a community user website and forum (http://sites.google.com/site/gimappingsuite). CONCLUSIONS: This software allows for the rapid analysis and generation of critical results from gastrointestinal high-resolution electrical mapping data, including quantitative analysis and graphical outputs for qualitative analysis. The software is designed to be used by non-experts in data and signal processing, and is intended to be used by clinical researchers as well as physiologists and bioengineers. The use and distribution of this software package will greatly accelerate efforts to improve the understanding of the causes and clinical consequences of gastrointestinal electrical disorders, through high-resolution electrical mapping

The gastrointestinal electrical mapping suite (GEMS): software for analyzing and visualizing high-resolution (multi-electrode) recordings in spatiotemporal detail

Abstract Background Gastrointestinal contractions are controlled by an underlying bioelectrical activity. High-resolution spatiotemporal electrical mapping has become an important advance for investigating gastrointestinal electrical behaviors in health and motility disorders. However, research progress has been constrained by the low efficiency of the data analysis tasks. This work introduces a new efficient software package: GEMS (Gastrointestinal Electrical Mapping Suite), for analyzing and visualizing high-resolution multi-electrode gastrointestinal mapping data in spatiotemporal detail. Results GEMS incorporates a number of new and previously validated automated analytical and visualization methods into a coherent framework coupled to an intuitive and user-friendly graphical user interface. GEMS is implemented using MATLAB®, which combines sophisticated mathematical operations and GUI compatibility. Recorded slow wave data can be filtered via a range of inbuilt techniques, efficiently analyzed via automated event-detection and cycle clustering algorithms, and high quality isochronal activation maps, velocity field maps, amplitude maps, frequency (time interval) maps and data animations can be rapidly generated. Normal and dysrhythmic activities can be analyzed, including initiation and conduction abnormalities. The software is distributed free to academics via a community user website and forum (http://sites.google.com/site/gimappingsuite). Conclusions This software allows for the rapid analysis and generation of critical results from gastrointestinal high-resolution electrical mapping data, including quantitative analysis and graphical outputs for qualitative analysis. The software is designed to be used by non-experts in data and signal processing, and is intended to be used by clinical researchers as well as physiologists and bioengineers. The use and distribution of this software package will greatly accelerate efforts to improve the understanding of the causes and clinical consequences of gastrointestinal electrical disorders, through high-resolution electrical mapping.</p

Intercorrência audiológica em músicas após um show de rock Hearing incidents in musicians after a rock concert

OBJETIVO: verificar mudança temporária do limiar de audição de músicos, após exposição a níveis de pressão sonora elevados de um show de rock. MÉTODOS: foi utilizada uma amostra com seis músicos componentes da banda. Foram feitos: anamnese ocupacional, determinação dos níveis mínimos de audição e reflexos acústicos, antes e após o show de rock. A mensuração do ruído da sala do exame e do palco foi realizada por meio de um dosímetro. Os resultados foram comparados e analisados estatisticamente, utilizando-se o teste t Student, com critério para determinação de significância de p maior do que 0,05. RESULTADOS: para a dosimetria, foi encontrada a exposição ao ruído do show com valor de LAVG igual a 98,5 dB. Dentre os aspectos comportamentais relacionados ao ruído, o zumbido foi a queixa mais presente entre os integrantes. Na audiometria tonal, as maiores diferenças pré e pós-exposição, foram encontradas nas freqüências altas, sendo a orelha direita a que apresentou maiores mudanças temporárias de limiar. Os resultados foram significantes nas freqüências de 2000, 3000, 4000 e 6000 Hz, na orelha direita (p=2,7; p=2,59; p=3,7 e p=2,86) e, na freqüência de 4000 Hz, na orelha esquerda (p=2,87). Na medida do reflexo acústico após o show, a orelha direita obteve o maior índice de ausência de reflexo, com o índice de 40%; entretanto, foram encontradas diferenças estatisticamente significantes, na presença de reflexo acústico na comparação pré e pós-exposição, apenas na orelha esquerda (p=3,64). CONCLUSÃO: músicos expostos a níveis de pressão sonora intensos apresentaram alteração temporária do limiar e alteração do reflexo acústico.<br>PURPOSE: verifying the temporary threshold shift in musicians after a high sound pressure level music exposure in a rock concert. METHODS: the sample has been made up of six band's musicians, who underwent an occupational anamnesis, pure tone audiometry and acoustic reflex measurements, before and after the rock concert. The noise levels of the room and the stage were determined by means of a dosimeter. The results were compared and statically analyzed using the t Student test with significance criterion of p> 0.05. the noise level found in the room and stage during the concert was 98.5 dB. As for the behavioral aspects related to the noise, tinnitus was the most prevalent complaint among the subjects. In pure tone audiometry, statistically significant differences were found in the hearing thresholds, before and after exposure, mostly in the right ear for the high frequencies. The results were also statistically significant at the frequencies between 2000Hz and 6000Hz, for the right ear (p=2.7; p=2.59; p=3.7 e p=2.86), and at the frequency of 4000Hz, for the left ear (p=2.87). The right ear's acoustic reflex has shown the highest index of absence (40%); however, we found statistically significant differences in the presence of the acoustic reflex, before and after exposure, only for the left ear (p=3.64). CONCLUSION: musicians exposed to high sound pressure levels in rock concerts have shown temporary threshold shift at the pure tone audiometry and acoustic reflex measurements

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Background: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings: Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p&lt;0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low. Interpretation: Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons