Variations in tectonic style and setting in British coalfields

British Carboniferous coalfield datasets are used for mapping, analysis, and modelling of depositional and structural patterns, through a significant stratigraphical range and across a variety of tectonic settings. Westphalian depositional patterns are re-interpreted using channel axis orientations. Major flows were northeasterly into northeast Britain, westerly into the Pennine Basin, and southwesterly through South Wales. Most systems prograded into freshwater lakes. Tectonic depocentres had little effect on channel pathways, but significant effects on net depositional thicknesses, and sandstone and coal connectivity patterns. Varying depositional controls are evaluated, and a complex model is proposed, integrating these; simple sequence stratigraphical interpretations are inappropriate. Many sulphur variations in the coals reflect the channel inflows rather than marine invasions, which were only occasionally important, and were moderated by many local effects. Structural and sedimentological criteria are proposed for the identification of syn-depositional faulting. Except in Scotland, few syn-depositional movements on specific faults are identifiable from the sedimentary record; some inherited structures continued to grow, as sub-basin bounding faults. These, and large post-depositional structures, generated mosaics of crustal compartments within which fault patterns and jointing orientations demonstrate varied block responses to tectonic events. Coal jointing orientations are considered to record Variscan near, far, and distant field stress, progressively north from South Wales, across central/northem England, and into Scotland. Recent data on Carboniferous igneous activity are described and interpreted in the Scottish Midland Valley. The Westphalian igneous provinces of the southern Pennine Basin and Oxfordshire are discussed and recommended for further research. Two case studies illustrate ways in which detailed coalfield data may be used for regional tectonic analysis, namely the evolution of the Kincardine Basin and Ochil Fault in Scotland, and the identification of a specific Variscan thrusting style in Kent

The iterated minimum modulus and conjectures of Baker and Eremenko

In transcendental dynamics significant progress has been made by studying points whose iterates escape to infinity at least as fast as iterates of the maximum modulus. Here we take the novel approach of studying points whose iterates escape at least as fast as iterates of the minimum modulus, and obtain new results related to Eremenko's conjecture and Baker's conjecture, and the rate of escape in Baker domains. To do this we prove a result of wider interest concerning the existence of points that escape to infinity under the iteration of a positive continuous function

Slow escaping points of quasiregular mappings

This article concerns the iteration of quasiregular mappings on Rd and entire functions on C. It is shown that there are always points at which the iterates of a quasiregular map tend to infinity at a controlled rate. Moreover, an asymptotic rate of escape result is proved that is new even for transcendental entire functions. Let f:Rd→Rd be quasiregular of transcendental type. Using novel methods of proof, we generalise results of Rippon and Stallard in complex dynamics to show that the Julia set of f contains points at which the iterates fn tend to infinity arbitrarily slowly. We also prove that, for any large R, there is a point x with modulus approximately R such that the growth of |fn(x)| is asymptotic to the iterated maximum modulus Mn(R,f)

On questions of Fatou and Eremenko

Let $f$ be a transcendental entire function and let $I(f)$ be the set of points whose iterates under $f$ tend to infinity. We show that $I(f)$ has at least one unbounded component. In the case that $f$ has a Baker wandering domain, we show that $I(f)$ is a connected unbounded set

Supporting induction: relationships count

This article examines the structural changes to the induction of teachers in Scotland using the perceptions of a group of final year student teachers. This group would be the first probationer teachers to experience revised arrangements for new teacher induction in 37 years. Their preferences and concerns are highlighted, as the new procedures roll out in schools nationwide, in an attempt to stress the importance of relationships to the success of the induction scheme. The argument put forward in this article is based on the notion that personal intelligence is central to effective relationships and therefore crucially important in the context of this mentoring relationship. The views of our sample provide evidence to suggest that the quality of interactions between the mentor and the probationer teacher are paramount in providing a good induction experience. These views are substantiated by experiences in England and in induction literature elsewhere. A synthesis of this evidence is used to make recommendations for those involved in supporting induction in schools, local authorities or teacher education institutions

Generation of lung epithelial-like tissue from human embryonic stem cells

<p>Abstract</p> <p>Background</p> <p>Human embryonic stem cells (hESC) have the capacity to differentiate <it>in vivo </it>and <it>in vitro </it>into cells from all three germ lineages. The aim of the present study was to investigate the effect of specific culture conditions on the differentiation of hESC into lung epithelial cells.</p> <p>Methods</p> <p>Undifferentiated hESC, grown on a porous membrane in hESC medium for four days, were switched to a differentiation medium for four days; this was followed by culture in air-liquid interface conditions during another 20 days. Expression of several lung markers was measured by immunohistochemistry and by quantitative real-time RT-PCR at four different time points throughout the differentiation and compared to appropriate controls.</p> <p>Results</p> <p>Expression of <it>CC16 </it>and <it>NKX2.1 </it>showed a 1,000- and 10,000- fold increase at day 10 of differentiation. Other lung markers such as <it>SP-C </it>and <it>Aquaporin 5 </it>had the highest expression after twenty days of culture, as well as two markers for ciliated cells, <it>FOXJ1 </it>and <it>β-tubulin IV</it>. The results from qRT-PCR were confirmed by immunohistochemistry on paraffin-embedded samples. Antibodies against CC16, SP-A and SP-C were chosen as specific markers for Clara Cells and alveolar type II cells. The functionality was tested by measuring the secretion of CC16 in the medium using an enzyme immunoassay.</p> <p>Conclusion</p> <p>These results suggest that by using our novel culture protocol hESC can be differentiated into the major cell types of lung epithelial tissue.</p

A comparison of the development of audiovisual integration in children with autism spectrum disorders and typically developing children

This study aimed to investigate the development of audiovisual integration in children with Autism Spectrum Disorder (ASD). Audiovisual integration was measured using the McGurk effect in children with ASD aged 7–16 years and typically developing children (control group) matched approximately for age, sex, nonverbal ability and verbal ability. Results showed that the children with ASD were delayed in visual accuracy and audiovisual integration compared to the control group. However, in the audiovisual integration measure, children with ASD appeared to ‘catch-up’ with their typically developing peers at the older age ranges. The suggestion that children with ASD show a deficit in audiovisual integration which diminishes with age has clinical implications for those assessing and treating these children

Historic landscape character and sense of place

This is an Author's Accepted Manuscript of an article published in Landscape Research, 2013, Vol. 38, Issue 2 pp.179-202, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/01426397.2012.672642.Most studies of landscape character within archaeology and historical geography have focused on morphological features such as whether settlement patterns were nucleated or dispersed, but this paper discusses how adding depth to this, for example by studying place-names, vernacular architecture, and the territorial structures within which a landscape was managed in the past, gives us a far greater understanding of its texture and meaning to local communities. In two case-studies in southern Essex, for example, it is shown how the connections that once existed between inland and coastal communities can be used today to promote public access to the countryside. A further case study, in southwest England, shows how field-/place-names and vernacular architecture also make an important contribution to our appreciation of the time depth and complexity of landscape character.Arts and Humanities Research Council (AHRC)Southend-on-Sea Borough Counci

Emerging applications of fluorescence spectroscopy in medical microbiology field

There are many diagnostic techniques and methods available for diagnosis of medically important microorganisms like bacteria, viruses, fungi and parasites. But, almost all these techniques and methods have some limitations or inconvenience. Most of these techniques are laborious, time consuming and with chances of false positive or false negative results. It warrants the need of a diagnostic technique which can overcome these limitations and problems. At present, there is emerging trend to use Fluorescence spectroscopy as a diagnostic as well as research tool in many fields of medical sciences. Here, we will critically discuss research studies which propose that Fluorescence spectroscopy may be an excellent diagnostic as well as excellent research tool in medical microbiology field with high sensitivity and specificity

Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model

Our aim was to differentiate human (h) embryonic stem (ES) cells into lung epithelial lineage-specific cells [i.e., alveolar epithelial type I (AEI) and type II (AEII) cells and Clara cells] as the first step in the development of cell-based strategies to repair lung injury in the bleomycin mouse model of idiopathic pulmonary fibrosis (IPF). A heterogeneous population of non-ciliated lung lineage-specific cells was derived by a novel method of embryoid body (EB) differentiation. This differentiated human cell population was used to modulate the profibrotic phenotype in transplanted animals.Omission or inclusion of one or more components in the differentiation medium skewed differentiation of H7 hES cells into varying proportions of AEI, AEII, and Clara cells. ICG-001, a small molecule inhibitor of Wnt/β-catenin/Creb-binding protein (CBP) transcription, changed marker expression of the differentiated ES cells from an AEII-like phenotype to a predominantly AEI-like phenotype. The differentiated cells were used in xenograft transplantation studies in bleomycin-treated Rag2γC(-/-) mice. Human cells were detected in lungs of the transplanted groups receiving differentiated ES cells treated with or without ICG-001. The increased lung collagen content found in bleomycin-treated mice receiving saline was significantly reduced by transplantation with the lung-lineage specific epithelial cells differentiated from ES cells. A significant increase in progenitor number was observed in the airways of bleomycin-treated mice after transplantation of differentiated hES cells.This study indicates that ES cell-based therapy may be a powerful novel approach to ameliorate lung fibrosis