Sharp HI edges at high z: the gas distribution from Damped Lyman-alpha to Lyman-limit absorption systems

We derive the distribution of neutral and ionized gas in high redshift clouds which are optically thick to hydrogen ionizing radiation, using published data on Lyman-limit and Damped Lyman-alpha absorption systems in the redshift range 1.75 < z < 3.25. We assume that the distribution of the hydrogen total (HI+HII) column density in the absorbers follows a power law K N_H^{-alpha}, whereas the observed HI column density distribution deviates from a pure power law as a result of ionization from a background radiation field. Comparison of the models and observations give Maximum Likelihood solutions for the exponent alpha and for X, the value of log(N_H/N_HI) when the Lyman-limit optical depth is unity: alpha=2.7^{+1.0}_{-0.7} and X=2.75\pm0.35. X is much lower than what would be obtained for a gaseous distribution in equilibrium under its own gravity but the ratio of dark matter to gas density is not well constrained being log(eta_0)=1.1\pm 0.8. An extrapolation of our derived power law distribution towards systems of lower column density, the Lyman-alpha forest, favours models with log(eta_0) < 1.1 and alpha=2.7-3.3. With alpha appreciably larger than 2, Lyman-limit systems contain more gas than Damped Lyman-alpha systems and Lyman-alpha forest clouds even more. Estimates of the cosmological gas and dark matter density due to absorbers of different column density around z=2.5 are also given.Comment: 21 pages, 6 figures. Accepted for publication in Ap

Tuning hole mobility in InP nanowires

Transport properties of holes in InP nanowires were calculated considering electron-phonon interaction via deformation potentials, the effect of temperature and strain fields. Using molecular dynamics, we simulate nanowire structures, LO-phonon energy renormalization and lifetime. The valence band ground state changes between light- and heavy-hole character, as the strain fields and the nanowire size are changed. Drastic changes in the mobility arise with the onset of resonance between the LO-phonons and the separation between valence subbands.Comment: 4 pages, 4 figure

Association of Phosphodiesterase-5 Inhibitors Versus Alprostadil With Survival in Men With Coronary Artery Disease

Abstract Background Phosphodiesterase 5 inhibitor (PDE5i) treatment is associated with reduced mortality compared with no treatment for erectile dysfunction after myocardial infarction (MI). Objectives This study sought to investigate the association between treatment with PDE5i or alprostadil and outcomes in men with stable coronary artery disease. Methods All Swedish men with a prior MI or revascularization who received PDE5i or alprostadil during 2006 through 2013 at >6 months after the event were included, using the Swedish Patient Register and the Swedish Prescribed Drug Register. Cox regression was used to estimate adjusted hazard ratios with 95% confidence intervals for all-cause mortality, MI, heart failure, cardiovascular mortality, noncardiovascular mortality, cardiac revascularization, peripheral arterial disease, and stroke in men treated with PDE5i versus alprostadil. Results This study included 16,548 men treated with PDE5i and 1,994 treated with alprostadil. The mean follow-up was 5.8 years, with 2,261 deaths (14%) in the PDE5i group and 521 (26%) in the alprostadil group. PDE5i compared with alprostadil treatment was associated with lower mortality (hazard ratio: 0.88; 95% confidence interval: 0.79 to 0.98) and with similar associations for MI, heart failure, cardiovascular mortality, and revascularization. When quintiles (q) of filled PDE5i prescriptions were compared using q1 as reference, patients in q3, q4, and q5 had lower all-cause mortality. Among alprostadil users, those in q5 had a lower all-cause mortality compared to q1. Conclusions In men with stable coronary artery disease, treatment with PDE5i is associated with lower risks of death, MI, heart failure, and revascularization compared with alprostadil treatment. Although the decrease in all-cause mortality was PDE5i dose dependent, the data do not permit the inference of causality or any clinical benefits of PDE5i because of the observational study design

The Structure, Dynamics and Electronic Structure of Liquid Ag-Se Alloys Investigated by Ab Initio Simulation

Ab initio molecular-dynamics simulations have been used to investigate the structure, dynamics and electronic properties of the liquid alloy Ag(1-x)Se(x) at 1350 K and at the three compositions x=0.33, 0.42 and 0.65. The calculations are based on density-functional theory in the local density approximation and on the pseudopotential plane-wave method. The reliability of the simulations is confirmed by detailed comparisons with very recent neutron diffraction results for the partial structure factors and radial distribution functions (RDF) of the stoichiometric liquid Ag2Se. The simulations show a dramatic change of the Se-Se RDF with increasing Se content. This change is due to the formation of Se clusters bound by covalent bonds, the Se-Se bond length being almost the same as in pure c-Se and l-Se. The clusters are predominantly chain-like, but for higher x a large fraction of 3-fold coordinated Se atoms is also found. It is shown that the equilibrium fractions of Se present as isolated atoms and in clusters can be understood on a simple charge-balance model based on an ionic interpretation. The Ag and Se diffusion coefficients both increase with Se content, in spite of the Se clustering. An analysis of the Se-Se bond dynamics reveals surprisingly short bond lifetimes of less than 1 ps. The changes in the density of states with composition arise directly from the formation of Se-Se covalent bonds. Results for the electronic conductivity obtained using the Kubo-Greenwood approximation are in adequate agreement with experiment for l-Ag2Se, but not for the high Se contents. Possible reasons for this are discussed.Comment: 14 pages, Revtex, 14 Postscript figures embedded in the tex

Static and Dynamic Properties of a Viscous Silica Melt Molecular Dynamics Computer Simulations

We present the results of a large scale molecular dynamics computer simulation in which we investigated the static and dynamic properties of a silica melt in the temperature range in which the viscosity of the system changes from O(10^-2) Poise to O(10^2) Poise. We show that even at temperatures as high as 4000 K the structure of this system is very similar to the random tetrahedral network found in silica at lower temperatures. The temperature dependence of the concentration of the defects in this network shows an Arrhenius law. From the partial structure factors we calculate the neutron scattering function and find that it agrees very well with experimental neutron scattering data. At low temperatures the temperature dependence of the diffusion constants $D$ shows an Arrhenius law with activation energies which are in very good agreement with the experimental values. With increasing temperature we find that this dependence shows a cross-over to one which can be described well by a power-law, D\propto (T-T_c)^gamma. The critical temperature T_c is 3330 K and the exponent gamma is close to 2.1. Since we find a similar cross-over in the viscosity we have evidence that the relaxation dynamics of the system changes from a flow-like motion of the particles, as described by the ideal version of mode-coupling theory, to a hopping like motion. We show that such a change of the transport mechanism is also observed in the product of the diffusion constant and the life time of a Si-O bond, or the space and time dependence of the van Hove correlation functions.Comment: 30 pages of Latex, 14 figure

Photoluminescence studies of a perceived white light emission from a monolithic InGaN/GaN quantum well structure

In this work we demonstrate by photoluminescence studies white light emission from a monolithic InGaN/GaN single quantum well structure grown by metal organic chemical vapour deposition. As-grown and thermally annealed samples at high temperature (1000 °C, 1100 °C and 1200 °C) and high pressure (1.1 GPa) were analysed by spectroscopic techniques, and the annealing effect on the photoluminescence is deeply explored. Under laser excitation of 3.8 eV at room temperature, the as-grown structure exhibits two main emission bands: a yellow band peaked at 2.14 eV and a blue band peaked at 2.8 eV resulting in white light perception. Interestingly, the stability of the white light is preserved after annealing at the lowest temperature (1000 °C), but suppressed for higher temperatures due to a deterioration of the blue quantum well emission. Moreover, the control of the yellow/blue bands intensity ratio, responsible for the white colour coordinate temperatures, could be achieved after annealing at 1000 °C. The room temperature white emission is studied as a function of incident power density, and the correlated colour temperature values are found to be in the warm white range: 3260–4000 K

Scattering of gravitational radiation

Aims.The effect of gravitational microlensing on the intensity of gravitational radiation as it propagates through an inhomogeneous medium is considered. Lensing by both stars and a power law spectrum of density perturbations is examined. Methods.The long wavelengths characteristic of gravitational radiation mandate a statistical, physical-optics approach to treat the effect of the lensing. Results.A model for the mass power spectrum of a starfield, including the effects of clustering and allowing for a distribution of stellar masses, is constructed and used to determine both the amplitude of fluctuations in the gravitational wave strain and its associated temporal fluctuation spectrum. For a uniformly distributed starfield the intensity variance scales linearly with stellar density, σ, but is enhanced by a factor \ga$\sigma r_{\rm F}^2$ when clustering is important, where rF is the Fresnel scale. The effect of lensing by a power law mass spectrum, applicable to lensing by small scale fluctuations in gas and dark matter, is also considered. For power law mass density spectra with indices steeper than -2 the wave amplitude exhibits rms fluctuations $1.3 \langle \Delta \Sigma^2\rangle^{1/4} (D_{\rm eff}/1\,{\rm Gpc})^{1/2}$%, where $\langle \Delta \Sigma^2 \rangle$ is the variance in the mass surface density measured in $M_\odot^2 \,{\rm pc}^{-4}$ and Deff is the effective distance to the lensing medium. For shallower spectra the amplitude of the fluctuations depends additionally on the inner length scale and power law index of the density fluctuations. The intensity fluctuations are dominated by temporal fluctuations on long timescales. For lensing material moving at a speed v across the line of sight the fluctuation timescale exceeds $v^{-1} (D_{\rm eff} \lambda)^{1/2}$. Lensing by small scale structure induces at most ≈15% rms variations if the line of sight to a gravitational wave source intersects a region with densities ~$100~M_\odot\,{\rm pc}^{-2}$, which are typically encountered in the vicinity of galaxy clusters

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT) adjuvant. The individual component(s) responsible for paralysis were not identified, and the vaccine was withdrawn. METHODOLOGY/PRINCIPAL FINDINGS: Subjects participating in two contemporaneous non-randomized Phase 1 clinical trials of nasal subunit vaccines against Human Immunodeficiency Virus and tuberculosis, both of which employed an enzymatically inactive non-toxic mutant LT adjuvant (LTK63), underwent active follow-up for adverse events using diary-cards and clinical examination. Two healthy subjects experienced transient peripheral facial nerve palsies 44 and 60 days after passive nasal instillation of LTK63, possibly a result of retrograde axonal transport after neuronal ganglioside binding or an inflammatory immune response, but without exaggerated immune responses to LTK63. CONCLUSIONS/SIGNIFICANCE: While the unique anatomical predisposition of the facial nerve to compression suggests nasal delivery of neuronal-binding LT-derived adjuvants is inadvisable, their continued investigation as topical or mucosal adjuvants and antigens appears warranted on the basis of longstanding safety via oral, percutaneous, and other mucosal routes

Doping of Ga2O3 bulk crystals and NWs by ion implantation

Ga2O3 bulk single crystals have been implanted with 300 keV Europium ions to fluences ranging from 1x10(13) to 4x10(15) at/cm(2). The damage build-up and Eu-incorporation was assessed by Rutherford Backscattering Spectrometry in the channeling mode (RBS/C). RBS/C results suggest that implantation causes a mixture of defect clusters and extended defects such as dislocations. Amorphisation starts at the surface for fluences around 1x10(15) at/cm(2) and then proceeds to deeper regions of the sample with increasing fluence. Amorphous regions and defect clusters are efficiently removed during rapid thermal annealing at similar to 1100 degrees C; however, Eu diffuses towards the surface. Nevertheless, Eu ions are optically activated and show cathodoluminescence at room temperature. Results in bulk samples are compared to those in Eu-implanted Ga2O3 nanowires and despite strong similarities in the structural properties differences were found in the optical activation. Furthermore, damage and dopant incorporation studies were performed using the Perturbed Angular Correlation technique, which allows probing the immediate lattice surroundings of an implanted radioactive probe at the atomic level