Cloud Computing Issues

Abstract- Cloud computing is Internet-based computing, whereby shared resources, software and information, are provided to computers and devices on-demand, like the electricity grid. It aims to construct a perfect system with powerful computing capability through a large number of relatively low-cost computing entity, and using the advanced business models like SaaS (Software as a Service), PaaS (Platform as a Service), IaaS (Infrastructure as a Service) to distribute the powerful computing capacity to end users’ hands. Cloud Computing represents a new computing model that poses many demanding security issues at all levels, e.g., network, host, application, and data levels. The variety of the delivery models presents different security challenges depending on the model and consumers’ Quality of Service (QoS) requirements. Confidentiality, Integrity, Availability, Authenticity, and Privacy are essential concerns for both Cloud providers and consumers as well. This paper introduces the existing issues in cloud computing such as security, privacy, reliability and so on. This paper surveys the security problems of current cloud computing

Hysterolaparoscopy as a one-time approach in infertility: a prospective study

Background: The prevalence of infertility ranges from 3.5% to 16.7% in more developed nations and from 6.9% to 9.3% in less developed nations, with an estimated overall median prevalence of 9%. The present study was aimed to evaluate the role of hysterolaparoscopy in the study of primary and secondary infertility, to identify the various pathological conditions in female reproductive tract leading to primary/ secondary infertility, to develop a plan for therapy and management at the same time.Methods: This is a one-year prospective study conducted in obstetrics and gynecology department at D. Y. Patil hospital, Navi Mumbai, Maharashtra, India. All infertility patients seen in outpatient department, who were medically fit, willing for surgery and willing to get enrolled for study were included in this study.Results: Out of total 120 cases for infertility evaluated, tubal factor is the most common cause (28.3%) in both primary (23.3%) and secondary (43.3%) infertility group as seen on laparoscopy. Followed by ovarian factors (28.3%), peritoneal (11.6%) and uterine factors (10.8%). In 27 cases (22%), there were no detectable pathology at laparoscopy. In this study, hysteroscopy findings show 5.8% cases to have submucous fibroid uterus, 3.3% submucous polyp, 1.6% subseptate uterus, 0.8% septate uterus, 0.8% intrauterine adhesions, 0.8% bicornuate uterus and cervical stenosis 1.6% of patients.Conclusions: From this study, it is concluded that the diagnostic hysteroscopy and laparoscopy is an effective and safe tool in evaluation of female infertility. It provides direct and magnified view of all pelvic organs

RECENT ADVANCES IN HYDROGELS FOR BIOMEDICAL APPLICATIONS

Hydrogels are three-dimensional polymeric network, capable of entrapping substantial amounts of fluids. Hydrogels are formed due to physical or chemical cross-linking in different synthetic and natural polymers. Recently, hydrogels have been receiving much attention for biomedical applications due to their innate structure and compositional similarities to the extracellular matrix. Hydrogels fabricated from naturally derived materials provide an advantage for biomedical applications due to their innate cellular interactions and cellular-mediated biodegradation. Synthetic materials have the advantage of greater tunability when it comes to the properties of hydrogels. There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for biomedical applications. The primary objective of this article is to review the classification of hydrogels based on their physical and chemical characteristics. It also reviews the technologies adopted for hydrogel fabrication and the different applications of hydrogels in the modern era

Robust pseudogap across the magnetic field driven superconductor to insulator-like transition in strongly disordered NbN films

We investigate the magnetic field evolution of the superconducting state in a strongly disordered NbN thin film which exhibits a magnetic field tuned superconductor to insulator-like transition, employing low temperature scanning tunneling spectroscopy (STS). Transport measurements of the sample reveals a characteristic magnetic field, which separates the low field state where resistance decreases with decreasing temperature, i.e. dR/dT > 0 and a high-field state where dR/dT < 0. However, STS imaging of the superconducting state reveals a smooth evolution across this field and the presence of a robust pseudogap on both sides of this characteristic field. Our results suggest that the superconductor-insulator transition might be a percolative transition driven by the shrinking of superconducting fraction with magnetic field.Comment: 22 pages, 8 figures including supplementary materia

Two step disordering of the vortex lattice across the peak effect in a weakly pinned Type II superconductor, Co0.0075NbSe2

The vortex lattice in a Type II superconductor provides a versatile model system to investigate the order-disorder transition in a periodic medium in the presence of random pinning. Here, using scanning tunnelling spectroscopy in a weakly pinned Co0.0075NbSe2 single crystal, we show that at low temperatures, the vortex lattice in a 3-dimensional superconductor disorders in two steps across the peak effect. At the onset of the peak effect, the equilibrium Bragg glass transforms into an orientational glass through the proliferation of dislocations. At a higher field, the dislocations dissociate into isolated disclination giving rise to an amorphous vortex glass. We also show the existence of a variety of additional non-equilibrium metastable states, which can be accessed through different thermomagnetic cycling.Comment: The analysis of the positional and orientational correlation functions have been refined in this version of the manuscrip

Anti-lipolytic activity and phytochemical screening of Chelianthesalbomarginata against pathogenic microorganisms

The aim of the present study was to evaluate the therapeutic properties of selected fern, Chelianthusalbomarginata and to identify its functional compounds. The methanolic fern-extract (MFE) of these ferns was assessed for anti-bacterial activities by measuring inhibition zones against a panel of pathogenic bacterial strains using agar diffusion method. MFE at a concentration of 25 μg/ml showed marked anti-bacterial activity against all bacterial strains (6-23mm zone of inhibition) and was maximum against Enterobacter sp (23 mm). In addition, the MFE of C. albomarginata had the best MIC values of 2.25µg/ml against S. aureus and Enterobacter sp., respectively. The MFE also possessed good anti-lipolytic activity (66.5%) against a porcine pancreatic lipase (PPL) and cholesterol oxidase inhibition (79%). This result showed that MFE of C. albomarginata under optimal concentration is not only a potent source of natural anti-oxidants and anti-bacterial activity but also possesses efficient cholesterol degradation and anti-lipolytic activities, that is to be beneficial in the body weight management

Anti-angiogenic therapy for cancer: Current progress, unresolved questions and future directions

Tumours require a vascular supply to grow and can achieve this via the expression of pro-angiogenic growth factors, including members of the vascular endothelial growth factor (VEGF) family of ligands. Since one or more of the VEGF ligand family is overexpressed in most solid cancers, there was great optimism that inhibition of the VEGF pathway would represent an effective anti-angiogenic therapy for most tumour types. Encouragingly, VEGF pathway targeted drugs such as bevacizumab, sunitinib and aflibercept have shown activity in certain settings. However, inhibition of VEGF signalling is not effective in all cancers, prompting the need to further understand how the vasculature can be effectively targeted in tumours. Here we present a succinct review of the progress with VEGF-targeted therapy and the unresolved questions that exist in the field: including its use in different disease stages (metastatic, adjuvant, neoadjuvant), interactions with chemotherapy, duration and scheduling of therapy, potential predictive biomarkers and proposed mechanisms of resistance, including paradoxical effects such as enhanced tumour aggressiveness. In terms of future directions, we discuss the need to delineate further the complexities of tumour vascularisation if we are to develop more effective and personalised anti-angiogenic therapies. © 2014 The Author(s)