1,719 research outputs found
Auditive direct in utero observation (Audio): A randomized controlled trial for a prenatal demonstration of fetal hearing
Introduction: The objective of this randomized controlled study was to demonstrate whether acoustic stimulation in utero is associated with fetal reactivity which is documentable by car-diotocography. Materials and methods: A monocentric randomized controlled trial was performed at a single university tertiary hospital between September 2016 and July 2017. This study was registered as a randomized clinical trial on clinicaltrail.gov (registration number NCT04622059). Unselected pregnancies at term of gestation were consecutively recruited for the purpose of this study. After 10 min of normal cardiotocography without accelerations (non-stress-test with a basal frequency between 110 and 150 beats/min, normal variability between 6 and 15 b/min, no accelerations, and no fetal movements), fetuses were randomized at a 1:1 ratio to either of the two groups. Fetuses in group A (n = 105) received acoustic stimulation after 10 min from the beginning of the CTG, whereas fetuses in group B received no stimulation (n = 105). The outcome variables investigated were the lapse of time between the beginning of the CTG and the occurrence of the first accelera-tion, and the lapse of time between the beginning of the CTG and the first fetal movement noticed. Results: The lapse of time between the beginning of the CTG and the occurrence of the first acceleration was significantly shorter in the group with acoustic stimulation compared to the other group (14.87 ± 5.01 vs. 21.90 ± 6.94 min, p-value < 0.001 log-rank test). Similarly, the lapse of time between the beginning of the CTG and the occurrence of the first fetal movement was significantly shorter in group A compared to group B (17.77 ± 7.62 vs. 23.28 ± 7.61 min, p-value < 0.001, log-rank test). Fetal cardiac acceleration and the occurrence of a fetal movement during the first 20 min of the CTG were more frequently recorded in group A compared to group B (respectively, 15% vs. 5% and 20% vs. 8%). Conclusion: This RCT showed an early fetal reaction following auditive stimulus, documentable by cardiotocography. Further research is needed to investigate a possible role of acoustic stimulation in utero for the prenatal diagnosis of congenital hypoacusis
Transverse momentum distributions and their forward- backward correlations in the percolating colour string approach
The forward-backward correlations in the distributions, which present a
clear signature of non-linear effects in particle production, are studied in
the model of percolating colour strings. Quantitative predictions are given for
these correlations at SPS, RHIC and LHC energies. Interaction of strings also
naturally explains the flattening of distributions and increase of
with energy and atomic number for nuclear collisionsComment: 6 pages in LaTex, 3 figures in Postscrip
Focus on Internal Urethrotomy as Primary Treatment for Untreated Bulbar Urethral Strictures: Results from a Multivariable Analysis
Background: The use of internal urethrotomy for treatment of urethral stricture remains a controversial topic in urology.Objective: To investigate outcomes and predictors of failure for internal urethrotomy as primary treatment for untreated bulbar urethral strictures.Design, setting, and participants: We performed a retrospective analysis of patients who underwent internal urethrotomy. Patients with bulbar urethral stricture who did not receive any previous treatment were included. Patients with traumatic, penile or posterior urethral strictures, lichen sclerosus, failed hypospadias repair, or stricture length >4 cm were excluded.Outcome measurements and statistical analysis: The primary outcome was treatment failure. Kaplan-Meyer plots were used to depict treatment failure-free survival. Univariate and multivariable Cox regression analyses were used to test the association between predictors (age, body mass index, diabetes, history of smoking, etiology, stenosis type and length, preoperative maximum flow [pQ(max)]) and treatment failure.Results and limitations: Overall, 136 patients were included. The median stricture length was 2 cm. Median follow-up was 55 mo. At 5-yr follow-up the failure-free survival rate was 57%. On univariate analysis, diabetes, nonidiopathic etiology, stricture length of 3-4 cm, and pQ(max) were significantly associated with treatment failure. These predictors were included in a multivariable analysis, in which pQ(max) was the only significant predictor of treatment failure.Conclusions: Failure of internal urethrotomy for untreated bulbar urethral strictures greatly depends on pQ(max) flow at uroflowmetry. Patients with pQ(max >) 8 ml/s have a high probability of success, while patients with pQ(max) <5 ml/s have a low probability of success.Patient summary: The use of internal urethrotomy in patients with an untreated bulbar urethral stricture should only be considered in selected cases. (C) 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved
Charged-Particle Multiplicity in Proton-Proton Collisions
This article summarizes and critically reviews measurements of
charged-particle multiplicity distributions and pseudorapidity densities in
p+p(pbar) collisions between sqrt(s) = 23.6 GeV and sqrt(s) = 1.8 TeV. Related
theoretical concepts are briefly introduced. Moments of multiplicity
distributions are presented as a function of sqrt(s). Feynman scaling, KNO
scaling, as well as the description of multiplicity distributions with a single
negative binomial distribution and with combinations of two or more negative
binomial distributions are discussed. Moreover, similarities between the energy
dependence of charged-particle multiplicities in p+p(pbar) and e+e- collisions
are studied. Finally, various predictions for pseudorapidity densities, average
multiplicities in full phase space, and multiplicity distributions of charged
particles in p+p(pbar) collisions at the LHC energies of sqrt(s) = 7 TeV, 10
TeV, and 14 TeV are summarized and compared.Comment: Invited review for Journal of Physics G -- version 2: version after
referee's comment
Clan Structure Analysis and Rapidity Gap Probability
Clan structure analysis in rapidity intervals is generalized from negative
binomial multiplicity distribution to the wide class of compound Poisson
distributions. The link of generalized clan structure analysis with correlation
functions is also established. These theoretical results are then applied to
minimum bias events and evidentiate new interesting features, which can be
inspiring and useful in order to discuss data on rapidity gap probability at
TEVATRON and HERA.Comment: (14 pages in Plain TeX plus 5 Postscript Figures, all compressed via
uufiles) DFTT 28/9
Validation of techniques to mitigate copper surface contamination in CUORE
In this article we describe the background challenges for the CUORE
experiment posed by surface contamination of inert detector materials such as
copper, and present three techniques explored to mitigate these backgrounds.
Using data from a dedicated test apparatus constructed to validate and compare
these techniques we demonstrate that copper surface contamination levels better
than 10E-07 - 10E-08 Bq/cm2 are achieved for 238U and 232Th. If these levels
are reproduced in the final CUORE apparatus the projected 90% C.L. upper limit
on the number of background counts in the region of interest is 0.02-0.03
counts/keV/kg/y depending on the adopted mitigation technique.Comment: 10 pages, 6 figures, 6 table
Search for 14.4 keV solar axions from M1 transition of Fe-57 with CUORE crystals
We report the results of a search for axions from the 14.4 keV M1 transition
from Fe-57 in the core of the sun using the axio-electric effect in TeO2
bolometers. The detectors are 5x5x5 cm3 crystals operated at about 10 mK in a
facility used to test bolometers for the CUORE experiment at the Laboratori
Nazionali del Gran Sasso in Italy. An analysis of 43.65 kg d of data was made
using a newly developed low energy trigger which was optimized to reduce the
detectors energy threshold. An upper limit of 0.63 c kg-1 d-1 was established
at 95% C.L.. From this value, a lower bound at 95% C.L. was placed on the
Peccei-Quinn energy scale of fa >= 0.76 10**6 GeV for a value of S=0.55 for the
flavor-singlet axial vector matrix element. Bounds are given for the interval
0.15 < S < 0.55.Comment: 14 pages, 6 figures, submitted to JCA
The low energy spectrum of TeO2 bolometers: results and dark matter perspectives for the CUORE-0 and CUORE experiments
We collected 19.4 days of data from four 750 g TeO2 bolometers, and in three
of them we were able to set the energy threshold around 3 keV using a new
analysis technique. We found a background rate ranging from 25 cpd/keV/kg at 3
keV to 2 cpd/keV/kg at 25 keV, and a peak at 4.7 keV. The origin of this peak
is presently unknown, but its presence is confirmed by a reanalysis of 62.7
kg.days of data from the finished CUORICINO experiment. Finally, we report the
expected sensitivities of the CUORE0 (52 bolometers) and CUORE (988 bolometers)
experiments to a WIMP annual modulation signal.Comment: 9 pages, 10 figure
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