Effects of microgravity on rat muscle

It is well known that humans exposed to long term spaceflight experience undesirable progressive muscle weakness and increased fatigability. This problem has prompted the implementation of inflight exercise programs because most investigators believe that the major cause of diminished muscle performance is a combination of disuse and decreased workload. Inflight exercise has improved muscle health, but deficits have persisted, indicating that either the regimens utilized were suboptimal or there existed additional debilitating factors which were not remedied by exercise. Clarification of this question requires an improved understanding of the cellular and molecular basis of spaceflight-induced muscle deterioration. To this end, multiple investigations have been performed on the muscles from rats orbited 5 to 22 days in Cosmos biosatellites and Spacelab-3 (2,4,5,8,10 to 14,16,18,19,21 to 23,25,27,28). The eight Cosmos 1887 investigations examined the structural and biochemical changes in skeletal and cardiac muscles of rats exposed to microgravity for 12.5 days and returned to terrestrial gravity 2.3 days before tissues were collected. Even though interpretation of these results was complicated by the combination of inflight and postflight induced alterations, the consensus is that there is marked heterogeneity in both degree and type of responses from the whole muscle level down to the molecular level. Collectively, the muscle investigations of Cosmos 1887 clearly illustrate the wide diversity of muscle tissue responses to spaceflight. Judging from the summary report of this mission, heterogeneity of responses is not unique to muscle tissue. Elucidating the mechanism underlying this heterogeneity holds the key to explaining adaptation of the organism to prolonged spaceflight

GRAINS AND OILSEEDS OUTLOOK FOR 1999

Crop Production/Industries,

GRAINS AND OILSEEDS OUTLOOK FOR 2003

Crop Production/Industries,

Ka-band (32 GHz) spacecraft development plan

A road map for the development of a protoflight 32 GHz spacecraft solid state transmitter is given. The major milestones include the development of device and component technology required for use in the spaceborne experimental and operational transmitter systems. Two experimental spacecraft transmitter systems are envisioned: first, a low power beacon, to determine the performance of a 32 GHz downlink communications system; and second, an array feed, to further verify the results of the first experiment and service as a test bed for technology required for an operational system. The first experiment was proposed to NASA Headquarters for flight aboard the Mars Observer spacecraft with spacecraft integration in early 1989. The second is to be available for integration aboard a spacecraft such as the Comet Rendezvous Asteroid Flyby (CRAF) mission in the 1990 time frame. These experimental systems are to lead to the development of a protoflight transmitter for subsequent spacecraft integration in 1992, the time frame of the Cassini mission to Saturn

Issues of scale for environmental indicators

The value of environmental indicators largely depends upon the spatial and temporal scale that they represent. Environmental indicators are dependent upon data availability and also upon the scale for which statements are required. As these may not match, changes in scales may be necessary. In this paper a geostatistical approach to analyse quantitative environmental indicators has been used. Scales, defined in terms of resolution and procedures, are presented to translate data from one scale to another: upscaling to change from high resolution data towards a low resolution, and downscaling for the inverse process. The study is illustrated with three environmental indicators. The first concerns heavy metals in the environment, where the zinc content is used as the indicator. Initially, data were present at a 1km2 resolution, and were downscaled to 1m2 resolution. High resolution data collected later showed a reasonable correspondence with the downscaled data. Available covariates were also used. The second example is from the Rothamsted’s long-term experiments. Changes in scale are illustrated by simulating reduced data sets from the full data set on grass cuts. A simple regression model related the yield from these condcut to that of the first cut in the cropping season. Reducing data availability (upscaling) resulted in poor estimates of the regression coefficients. The final example is on nitrate surpluses on Danish farms. Data at the field level are upscaled to the farm level, and the dispersion variance indicates differences between different farms. Geostatistical methods were useful to define, change and determine the most appropriate scales for environmental variables in space and in time

A pitfall of piecewise-polytropic equation of state inference

The only messenger radiation in the Universe which one can use to statistically probe the Equation of State (EOS) of cold dense matter is that originating from the near-field vicinities of compact stars. Constraining gravitational masses and equatorial radii of rotating compact stars is a major goal for current and future telescope missions, with a primary purpose of constraining the EOS. From a Bayesian perspective it is necessary to carefully discuss prior definition; in this context a complicating issue is that in practice there exist pathologies in the general relativistic mapping between spaces of local (interior source matter) and global (exterior spacetime) parameters. In a companion paper, these issues were raised on a theoretical basis. In this study we reproduce a probability transformation procedure from the literature in order to map a joint posterior distribution of Schwarzschild gravitational masses and radii into a joint posterior distribution of EOS parameters. We demonstrate computationally that EOS parameter inferences are sensitive to the choice to define a prior on a joint space of these masses and radii, instead of on a joint space interior source matter parameters. We focus on the piecewise-polytropic EOS model, which is currently standard in the field of astrophysical dense matter study. We discuss the implications of this issue for the field.Comment: 16 pages, 9 figures. Accepted for publication in MNRA

A systematic review of reported reassortant viral lineages of influenza A

BACKGROUND: Most previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes. RESULTS: After adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade. CONCLUSIONS: Despite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-015-1298-9) contains supplementary material, which is available to authorized users