25 research outputs found
Creatine Fails to Augment the Benefits from Resistance Training in Patients with HIV Infection: A Randomized, Double-Blind, Placebo-Controlled Study
Get PDFProgressive resistance exercise training (PRT) improves physical functioning in patients with HIV infection. Creatine supplementation can augment the benefits derived from training in athletes and improve muscle function in patients with muscle wasting. The objective of this study was to determine whether creatine supplementation augments the effects of PRT on muscle strength, energetics, and body composition in HIV-infected patients.This is a randomized, double blind, placebo-controlled, clinical research center-based, outpatient study in San Francisco. 40 HIV-positive men (20 creatine, 20 placebo) enrolled in a 14-week study. Subjects were randomly assigned to receive creatine monohydrate or placebo for 14 weeks. Treatment began with a loading dose of 20 g/day or an equivalent number of placebo capsules for 5 days, followed by maintenance dosing of 4.8 g/day or placebo. Beginning at week 2 and continuing to week 14, all subjects underwent thrice-weekly supervised resistance exercise while continuing on the assigned study medication (with repeated 6-week cycles of loading and maintenance). The main outcome measurements included muscle strength (one repetition maximum), energetics ((31)P magnetic resonance spectroscopy), composition and size (magnetic resonance imaging), as well as total body composition (dual-energy X-ray absorptiometry). Thirty-three subjects completed the study (17 creatine, 16 placebo). Strength increased in all 8 muscle groups studied following PRT, but this increase was not augmented by creatine supplementation (average increase 44 vs. 42%, difference 2%, 95% CI -9.5% to 13.9%) in creatine and placebo, respectively). There were no differences between groups in changes in muscle energetics. Thigh muscle cross-sectional area increased following resistance exercise, with no additive effect of creatine. Lean body mass (LBM) increased to a significantly greater extent with creatine. CONCLUSIONS / SIGNIFICANCE: Resistance exercise improved muscle size, strength and function in HIV-infected men. While creatine supplementation produced a greater increase in LBM, it did not augment the robust increase in strength derived from PRT.ClinicalTrials.gov NCT00484627
Notes sur la Crète hellénistique
No full textRigsby Kent J. Notes sur la Crète hellénistique. In: Revue des Études Grecques, tome 99, fascicule 472-474, Juillet-décembre 1986. pp. 350-360
Chapter 13. Apollo and the Archons
No full textIn the north slope of the Athenian Acropolis, nature has shaped some shallow caves. Pausanias mentions two, attributing one to Pan and the other to Apollo (1.28.4). Kavvadias in 1896 established the identity of Apollo’s cave with certainty when he found in it several inscribed plaques dedicated to “Apollo under the Cliffs,” ύπο Μάκραις or ύπ’ ’Άκραις (the three texts of this type known before his excavation had not been found in situ). These small plaques, originally placed in niches in the c..
A Greek Dedication at Sidon
No full textSidon's chief temple of Eshmun stood beside the el-Awali river four kilometers north of the city, "Eshmun by the ydl spring", as he is often called in the Phoenician inscriptions
Founding a Sarapeum
No full textA letter in the Zenon archive (P.Cair.Zen. 59034 of 257 B.C.) urging the dioiketes Apollonius to help build a shrine of Sarapis concerns Memphis in Egypt, not a city overseas, and can be seen as an effort to give the Greeks of Memphis a cult place independent of the great Sarapeum outside of the city.</span
