585 research outputs found

    How can parent education be used as a resource to improve and promote healthy relationships with children?

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    From my observations I realized that if parents used education as a resource to educate themselves on how to communicate and use the knowledge acquired through parenting courses maybe relationships with their children would be less strained

    Supersonic combustor modeling

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    The physical phenomena involved when a supersonic flow undergoes chemical reaction are discussed. Detailed physical models of convective and diffusive mixing, and finite rate chemical reaction in supersonic flow are presented. Numerical algorithms used to solve the equations governing these processes are introduced. Computer programs using these algorithms are used to analyze the structure of the reacting mixing layer. It is concluded that, as in subsonic flow, exothermic heat release in unconfined supersonic flows retards fuel/air mixing. Non mixing is shown to be a potential problem in reducing the efficiency of supersonic as well as subsonic combustion. Techniques for enhancing fuel/air mixing and combustion are described

    The Digital Divide: Current and Future Research Directions

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    The digital divide refers to the separation between those who have access to digital information and communications technology (ICT) and those who do not. Many believe that universal access to ICT would bring about a global community of interaction, commerce, and learning resulting in higher standards of living and improved social welfare. However, the digital divide threatens this outcome, leading many public policy makers to debate the best way to bridge the divide. Much of the research on the digital divide focuses on first order effects regarding who has access to the technology, but some work addresses the second order effects of inequality in the ability to use the technology among those who do have access. In this paper, we examine both first and second order effects of the digital divide at three levels of analysis ? the individual level, the organizational level, and the global level. At each level, we survey the existing research noting the theoretical perspective taken in the work, the research methodology employed, and the key results that were obtained. We then suggest a series of research questions at each level of analysis to guide researchers seeking to further examine the digital divide and how it impacts citizens, managers, and economies

    Digital Transformation Through Internet of Things Services

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    Internet of Things (IoT) have been disrupting industries through shifting novel services, and business models. Organizations should also redesign their business service models to navigate this disruption. A holistic understanding of digital transformation through IoT requires the cooperation of multiple disciplines ranging from engineering to economics. This paper utilizes a conceptual model to develop an analytical framework to investigate a number of pricing strategies enabled by different business models. Our findings demonstrate that the Internet of Things phenomenon has the potential to disrupt the way we do business by connecting markets and enabling new business models

    On black hole thermalization, D0 brane dynamics, and emergent spacetime

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    When matter falls past the horizon of a large black hole, the expectation from string theory is that the configuration thermalizes and the information in the probe is rather quickly scrambled away. The traditional view of a classical unique spacetime near a black hole horizon conflicts with this picture. The question then arises as to what spacetime does the probe actually see as it crosses a horizon, and how does the background geometry imprint its signature onto the thermal properties of the probe. In this work, we explore these questions through an extensive series of numerical simulations of D0 branes. We determine that the D0 branes quickly settle into an incompressible symmetric state -- thermalized within a few oscillations through a process driven entirely by internal non-linear dynamics. Surprisingly, thermal background fluctuations play no role in this mechanism. Signatures of the background fields in this thermal state arise either through fluxes, i.e. black hole hair; or if the probe expands to the size of the horizon -- which we see evidence of. We determine simple scaling relations for the D0 branes' equilibrium size, time to thermalize, lifetime, and temperature in terms of their number, initial energy, and the background fields. Our results are consistent with the conjecture that black holes are the fastest scramblers as seen by Matrix theory.Comment: 43 pages, 12 figures; v2: added analysis showing that results are consistent with and confirm Susskind conjecture on black hole thermalization. Added clarification about strong coupling regime. Citation adde

    Identification of astrocytoma associated genes including cell surface markers

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    BACKGROUND: Despite intense effort the treatment options for the invasive astrocytic tumors are still limited to surgery and radiation therapy, with chemotherapy showing little or no increase in survival. The generation of Serial Analysis of Gene Expression (SAGE) profiles is expected to aid in the identification of astrocytoma-associated genes and highly expressed cell surface genes as molecular therapeutic targets. SAGE tag counts can be easily added to public expression databases and quickly disseminated to research efforts worldwide. METHODS: We generated and analyzed the SAGE transcription profiles of 25 primary grade II, III and IV astrocytomas [1]. These profiles were produced as part of the Cancer Genome Anatomy Project's SAGE Genie [2], and were used in an in silico search for candidate therapeutic targets by comparing astrocytoma to normal brain transcription. Real-time PCR and immunohistochemistry were used for the validation of selected candidate target genes in 2 independent sets of primary tumors. RESULTS: A restricted set of tumor-associated genes was identified for each grade that included genes not previously associated with astrocytomas (e.g. VCAM1, SMOC1, and thymidylate synthetase), with a high percentage of cell surface genes. Two genes with available antibodies, Aquaporin 1 and Topoisomerase 2A, showed protein expression consistent with transcript level predictions. CONCLUSIONS: This survey of transcription in malignant and normal brain tissues reveals a small subset of human genes that are activated in malignant astrocytomas. In addition to providing insights into pathway biology, we have revealed and quantified expression for a significant portion of cell surface and extra-cellular astrocytoma genes
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