Examining relationships between climate change and mental health in the Circumpolar North

Indigenous people living in the Circumpolar North rely, to varying degrees, on the natural environment and the resources it provides for their lifestyle and livelihoods. As a consequence, these Northern Indigenous peoples may be more sensitive to global climate change, which has implications for food security, cultural practices, and health and well-being. To date, most research on the human dimensions of climate change in the Circumpolar North has focused on biophysical issues and their consequences, such as changing sea ice regimes affecting travel to hunting grounds or the effects of melting permafrost on built infrastructure. Less is known about how these changes in the environment affect mental health and well-being. In this paper, we build upon existing research, combined with our community-based research and professional mental health practices, to outline some pathways and mechanisms through which climate change may adversely impact mental health and well-being in the Circumpolar North. Our analysis indicates that mental health may be affected by climate change due to changes to land, ice, snow, weather, and sense of place; impacts to physical health; damage to infrastructure; indirect impacts via media, research, and policy; and through the compounding of existing stress and distress. We argue that climate change is likely an emerging mental health challenge for Circumpolar Indigenous populations and efforts to respond through research, policy, and mental health programming should be a priority. We conclude by identifying next steps in research, outlining points for policy, and calling for additional mental health resources that are locally responsive and culturally relevant

\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu