6,210 research outputs found
Shape mode analysis exposes movement patterns in biology: flagella and flatworms as case studies
We illustrate shape mode analysis as a simple, yet powerful technique to
concisely describe complex biological shapes and their dynamics. We
characterize undulatory bending waves of beating flagella and reconstruct a
limit cycle of flagellar oscillations, paying particular attention to the
periodicity of angular data. As a second example, we analyze non-convex
boundary outlines of gliding flatworms, which allows us to expose stereotypic
body postures that can be related to two different locomotion mechanisms.
Further, shape mode analysis based on principal component analysis allows to
discriminate different flatworm species, despite large motion-associated shape
variability. Thus, complex shape dynamics is characterized by a small number of
shape scores that change in time. We present this method using descriptive
examples, explaining abstract mathematics in a graphic way.Comment: 20 pages, 6 figures, accepted for publication in PLoS On
Active phase and amplitude fluctuations of flagellar beating
The eukaryotic flagellum beats periodically, driven by the oscillatory
dynamics of molecular motors, to propel cells and pump fluids. Small, but
perceivable fluctuations in the beat of individual flagella have physiological
implications for synchronization in collections of flagella as well as for
hydrodynamic interactions between flagellated swimmers. Here, we characterize
phase and amplitude fluctuations of flagellar bending waves using shape mode
analysis and limit cycle reconstruction. We report a quality factor of
flagellar oscillations, (means.e.). Our analysis shows
that flagellar fluctuations are dominantly of active origin. Using a minimal
model of collective motor oscillations, we demonstrate how the stochastic
dynamics of individual motors can give rise to active small-number fluctuations
in motor-cytoskeleton systems.Comment: accepted for publication in Physical Review Letter
ICAM G241A polymorphism and soluble ICAM-1 serum levels: Evidence for an active immune process in schizophrenia
Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism ( SNP) of the ICAM-1 gene was described at position 241. The G --> A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like rheumatoid arthritis. Methods: We investigated 70 schizophrenic patients and 128 unrelated healthy control persons regarding the relationship between the serum levels of sICAM-1 and the ICAM-1 G214A polymorphism. Results: We were able to replicate our previous finding of reduced sICAM-1 levels in schizophrenia. Healthy control persons carrying the polymorphic A allele showed markedly lower sICAM-1 serum levels than carriers of the homozygous GG wild type ( p < 0.004). In contrast, no significant difference in the sICAM-1 serum levels were seen regarding the G241A genotype distribution in schizophrenic patients. Conclusion: We hypothesize that the biochemical effect of the G241A SNP is masked in schizophrenic patients, indicating a disease-related mechanism leading to reduced levels of sICAM-1 in schizophrenia. Copyright (C) 2005 S. Karger AG, Basel
A model for liquid phase sintering
AbstractA quantitative model for liquid phase sintering is developed based on the following ideas. During heating a liquid phase forms, which is easily mobile, wets the solid particles completely, dissolves solid atoms and provides an easy diffusion path for them. The solid density increases by particle rearrangement and by the flattening of particle contacts. Driving (or retarding) forces result from capillary stresses, from applied mechanical stresses, from the pressure of gas entrapped in closed pores and from differences in chemical potential of the dissolved and precipitated matter. At higher densities the driving force may become very small, since the liquid pressure decreases and a negative contribution from the solid-liquid interface energy increases. At this stage grain coarsening plays an important role for the continued filling of larger and larger pores. The model is applied to describe nonisothermal densification curves measured on Si3N4 for various hold temperatures, axial stresses and green densities. Adjusting a moderate number of parameters all having a physical meaning leads to good agreement between theory and experiment
Re-examination of the Population, Stratigraphy, and Sequence of Mercurian Basins: Implications for Mercurys Early Impact History and Comparison with the Moon
Mercury has one of the best preserved impact records in the inner Solar System due to the absence of an atmosphere, but it has much higher rates of surface modification than on the Moon. The earliest geological mapping of the planet revealed a variety of important differences from the Moon, regarding the impact basin (D 300 km) and cratering record, as well as the extensive volcanic plains of Mercury [1-3]. It has been shown [3] that the bombardment history of the terrestrial planets is lunar-like and linked in terms of impactor population(s) and impact rates. Recent studies suggest that Mercury and the Moon had the same early impactor populations based on the similarity of their crater size-frequency distributions (CSFD), however the impact rates on Mercury are higher than on the Moon. Catalogued and characterized the basin population on Mercury using early optical data obtained by the MESSENGER spacecraft and found 46 certain and probable impact basins, as well as 41 tentative
High and low molecular weight crossovers in the longest relaxation time dependence of linear cis-1,4 polyisoprene by dielectric relaxations
The dielectric relaxation of cis-1,4 Polyisoprene [PI] is sensitive not only to the local and segmental dynamics but also to the larger scale chain (end-to-end) fluctuations. We have performed a careful dielectric investigation on linear PI with various molecular weights in the range of 1 to 320 kg/mol. The broadband dielectric spectra of all samples were measured isothermally at the same temperature to avoid utilizing shift factors. For the low and medium molecular weight range, the comparisons were performed at 250 K to access both the segmental relaxation and normal mode peaks inside the available frequency window (1 mHz–10 MHz). In this way, we were able to observe simultaneously the effect of molecular mass on the segmental dynamics—related with the glass transition process—and on the end-to-end relaxation time of PI and thus decouple the direct effect of molecular weight on the normal mode from that due to the effect on the monomeric friction coefficient. The latter effect is significant for low molecular weight (M w < 33 kg/mol), i.e., in the range where the crossover from Rouse dynamics to entanglement limited flow occurs. Despite the conductivity contribution at low frequency, careful experiments allowed us to access to the normal mode signal for molecular weights as high as M w = 320 kg/mol, i.e., into the range of high molecular weights where the pure reptation behavior could be valid, at least for the description of the slowest chain modes. The comparison between the dielectric relaxations of PI samples with medium and high molecular weight was performed at 320 K. We found two crossovers in the molecular weight dependence of the longest relaxation time, the first around a molecular weight of 6.5 ± 0.5 kg/mol corresponding to the end of the Rouse regime and the second around 75 ± 10 kg/mol. Above this latter value, we find a power law compatible with exponent 3 as predicted by the De Gennes theory
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