Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum

This paper presents the first case of extensive, diffuse, somatostatin- immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and goiter. The density of the distribution of D cells was increased 39-fold in the stomach fundus, 23- fold in the proximal antrum, 25-fold in the distal antrum, and 31-fold in the upper duodenum in comparison with normal values. At the same time, the gastrin-immunoreactive cells were increased 2.3-fold in the antrum. Although the range in size of the D cells was within normal limits in all regions examined, the G cells showed pronounced hypertrophy of up to 127%. A possible relationship between the immuno- histochemical findings and the clinical picture is discussed

DNAReplication: a database of information and resources for the eukaryotic DNA replication community

DNAReplication (at http://www.dnareplication.net) has been set up as a freely available single resource to facilitate access to information on eukaryotic DNA replication. This database summarizes organism-sorted data on replication proteins in the categories of nomenclature, biochemical properties, motifs, interactions, modifications, structure, cell localization and expression, and general comments. Replication concepts are defined and a general model of the steps in DNA replication is presented. Links to relevant websites and homepages of replication labs are provided. The site also has an interactive section where links to recent replication papers are posted and readers are provided with the facility to post comments about each paper. The interactive and links pages are modified weekly and the whole site is updated annually

Pyramiding of Ryd2 and Ryd3 conferring tolerance to a German isolate of Barley yellow dwarf virus-PAV (BYDV-PAV-ASL-1) leads to quantitative resistance against this isolate

Barley yellow dwarf virus (BYDV) is an economically important pathogen of barley, which may become even more important due to global warming. In barley, several loci conferring tolerance to BYDV-PAV-ASL-1 are known, e.g. Ryd2, Ryd3 and a quantitative trait locus (QTL) on chromosome 2H. The aim of the present study was to get information whether the level of tolerance against this isolate of BYDV in barley can be improved by combining these loci. Therefore, a winter and a spring barley population of doubled haploid (DH) lines were genotyped by molecular markers for the presence of the susceptibility or the resistance encoding allele at respective loci (Ryd2, Ryd3, QTL on chromosome 2H) and were tested for their level of BYDV-tolerance after inoculation with viruliferous (BYDV-PAV-ASL-1) aphids in field trials. In DH-lines carrying the combination Ryd2 and Ryd3, a significant reduction of the virus titre was detected as compared to lines carrying only one of these genes. Furthermore, spring barley DH-lines with this allele combination also showed a significantly higher relative grain yield as compared to lines carrying only Ryd2 or Ryd3. The QTL on chromosome 2H had only a small effect on the level of tolerance in those lines carrying only Ryd2, or Ryd3 or a combination of both, but the effect in comparison to lines carrying no tolerance allele was significant. Overall, these results show that the combination of Ryd2 and Ryd3 leads to quantitative resistance against BYDV-PAV instead of tolerance

Glueball condensates as holographic duals of supersymmetric Q-balls and boson stars

We study non-spinning Q-balls and boson stars in 4-dimensional Anti-de Sitter (AdS) space-time. We use an exponential scalar field potential that appears in gauge-mediated supersymmetry (SUSY) breaking in the minimal supersymmetric extension of the Standard Model (MSSM). We investigate the dependence of the charge and mass of these non-topological solitons on the negative cosmological constant, the frequency that appears in the periodic time-dependence as well as on the ratio between the SUSY breaking scale and the Planck mass. Next to fundamental solutions without nodes in the scalar field function we also construct radially excited solutions. In the second part of the paper we put the emphasis on the holographic interpretation of these solutions in terms of Bose-Einstein condensates of scalar glueballs that are described by a strongly coupled Quantum Field Theory (QFT) on the boundary of global AdS.Comment: 17 pages including 11 figures; v2: 19 pages including 13 figures, references added, figures adde

Orbital Magnetic Ordering in Disordered Mesoscopic Systems

We present some model calculations of persistent currents in disordered one- and two-dimensional mesoscopic systems. We use the tight-binding model and calculate numerically the currents in small systems for several values of disorder. Next we fit appropriate analytical formulae, and using them we find self- -sustaining currents and critical fields in larger, more realistic systems with different shapes of the Fermi surfaces.Comment: 16 pages, LaTeX, 8 figures, in print in J. Magn. Magn. Ma