Children and Virtual Reality: Emerging Possibilities and Challenges

Virtual Reality is fast becoming a reality, with estimates that over 200m headsets will have been sold by 2020, and the market value for VR hardware and software reaching well over $20bn by then. Key players in the market currently include PlayStation with PSVR, Facebook with Oculus Rift, Google Cardboard and Daydream, Mattel with Viewmaster, and many other brands investing in content production for various audiences. One of those audiences is young people and children. “Children and Virtual Reality” is a collaboration between Dubit, Turner, WEARVR and the COST (European Cooperation in Science and Technology) Action DigiLitEY. Dubit, Turner and WEARVR are companies that specialise in digital, TV and VR content, with an interest in developing best practices around VR and children. DigiLitEY is a five year (2013-2017) academic network that focuses on existing and emerging communicative technologies for young children. This includes wearable technologies, 3D printers, robots, augmented reality, toys and games and relevant aspects of the Internet of Things. This report brings together industry research into the effects of VR on 8 to 12 year olds, and ideas that arose from a COST funded Think Tank to explore what the research findings might mean for the use of VR by under 8s

Polymorphism in Gag Gene Cleavage Sites of HIV-1 Non-B Subtype and Virological Outcome of a First-Line Lopinavir/Ritonavir Single Drug Regimen

Virological failure on a boosted-protease inhibitor (PI/r) first-line triple combination is usually not associated with the detection of resistance mutations in the protease gene. Thus, other resistance pathways are being investigated. First-line PI/r monotherapy is the best model to investigate in vivo if the presence of mutations in the cleavage sites (CS) of gag gene prior to any antiretroviral treatment might influence PI/r efficacy. 83 patients were assigned to initiate antiretroviral treatment with first-line lopinavir/r monotherapy in the randomised Monark trial. We compared baseline sequence of gag CS between patients harbouring B or non-B HIV-1 subtype, and between those who achieved viral suppression and those who experienced virological failure while on LPV/r monotherapy up to Week 96. Baseline sequence of gag CS was available for 82/83 isolates; 81/82 carried at least one substitution in gag CS compared to HXB2 sequence. At baseline, non-B subtype isolates were significantly more likely to harbour mutations in gag CS than B subtype isolates (p<0.0001). Twenty-three patients experienced virological failure while on lopinavir/r monotherapy. The presence of more than two substitutions in p2/NC site at baseline significantly predicted virological failure (p = 0.0479), non-B subtype isolates being more likely to harbour more than two substitutions in this specific site. In conclusion, gag cleavage site was highly polymorphic in antiretroviral-naive patients harbouring a non-B HIV-1 strain. We show that pre-therapy mutations in gag cleavage site sequence were significantly associated with the virological outcome of a first-line LPV/r single drug regimen in the Monark trial

The prelude to industrial whaling: identifying the targets of ancient European whaling using zooarchaeology and collagen mass-peptide fingerprinting

Taxonomic identification of whale bones found during archaeological excavations is problematic dueto their typically fragmented state. This difficulty limits understanding of both the past spatio-temporal distributions of whale populations and of possible early whaling activities. To overcomethis challenge, we performed zooarchaeology by mass spectrometry on an unprecedented 719archaeological and palaeontological specimens of probable whale bone from Atlantic Europeancontexts, predominantly dating fromca3500 BCE to the eighteenth century CE. The results showhigh numbers of Balaenidae (many probably North Atlantic right whale (Eubalaena  glacialis)) andgrey whale (Eschrichtius  robustus) specimens, two taxa no longer present in the eastern NorthAtlantic. This discovery matches expectations regarding the past utilization of North Atlantic rightwhales, but was unanticipated for grey whales, which have hitherto rarely been identified in theEuropean zooarchaeological record. Many of these specimens derive from contexts associated withmediaeval cultures frequently linked to whaling: the Basques, northern Spaniards, Normans,Flemish, Frisians, Anglo-Saxons and Scandinavians. This association raises the likelihood that earlywhaling impacted these taxa, contributing to their extirpation and extinction. Much lower numbersof other large cetacean taxa were identified, suggesting that what are now the most depletedwhales were once those most frequently used.Archaeological Heritage Managemen

Of saints, sows or smiths? Copper-brazed iron handbells in Early Medieval England

Copper-brazed iron handbells were a distinctive feature of monastic life in Early Medieval Ireland, Scotland and Wales. Handbells were used in liturgy, prayer, worship, and later as reliquaries. In England, brazed bells of the 7th to 9th centuries take on a greater range of sizes and forms and are found on a wider variety of sites. As a consequence, their roles within Christianity have been questioned, and associations with animals and itinerant smiths have been emphasised instead. Recent archaeological investigation of an Anglo-Saxon marsh-island at Little Carlton, Lincolnshire has resulted in one of the largest assemblages of copper-brazed iron bells from any site in England, comparable to similar collections from Flixborough and Brandon. Taking into consideration the inclusion of brazen bells in some ritualistic ‘closure hoards’, this paper argues that whilst Anglo-Saxon plain iron bells may have fulfilled a range of profane functions, those that were copper-brazed, regardless of their size, were important objects amongst early Christian communities in England, and the Northumbrian church in particular

Randomized clinical trial to assess the impact of the broadly neutralizing HIV-1 monoclonal antibody VRC01 on HIV-1 persistence in individuals on effective ART

Background. Broadly neutralizing monoclonal antibodies (bnMAbs) may promote clearance of HIV-1-expressing cells through antibody-dependent cell-mediated cytotoxicity. We evaluated the effect of the CD4-binding site bnMAb, VRC01, on measures of HIV-1 persistence in chronically infected individuals. Methods. A5342 was a phase 1, randomized, double-blind, placebo-controlled, parallel-arm study. Participants on effective antiretroviral therapy (ART) were randomized to receive 2 infusions of VRC01 (40 mg/kg) at entry and week 3, and 2 infusions of placebo (saline) at weeks 6 and 9; or 2 infusions of placebo at entry and week 3, and 2 infusions of VRC01 at weeks 6 and 9. Results. Infusion of VRC01 was safe and well tolerated. The median fold-change in the cell-associated HIV-1 RNA/DNA ratio from baseline to week 6 was 1.12 and 0.83 for the VRC01 and placebo arms, respectively, with no significant difference between arms (P = .16). There were no significant differences in the proportions with residual plasma viremia ≥1 copies/mL or in phorbol 12-myristate 13-acetate/ionomycin-induced virus production from CD4+ T cells between arms (both P &gt; .05). Conclusions. In individuals with chronic HIV-1 infection on ART, VRC01 infusions were safe and well tolerated but did not affect plasma viremia, cellular HIV-1 RNA/DNA levels, or stimulated virus production from CD4+ T cells

Imports and isotopes: a modern baseline study for interpreting Iron Age and Roman trade in fallow deer antlers

The European Fallow deer (Dama dama dama) became extinct in the British Isles and most of continental Europe at the time of the Last Glacial Maximum, with the species becoming restricted to an Anatolian refugium (Masseti et al. 2008). Human-mediated reintroductions resulted in fallow populations in Rhodes, Sicily, Mallorca, Iberia and other parts of western Europe (Sykes et al. 2013). Eventually, the species was brought to Britain by the Romans during the 1st century AD, with a breeding population being established at Fishbourne Roman Palace (Sykes et al. 2011). The human influence on the present-day distribution of the species makes it particularly interesting from a zooarchaeological perspective. This paper describes my MSc research, as part of the AHRC-funded project Dama International: Fallow Deer and European Society 6000 BC–AD 1600, looking at antlers from Iron Age and Roman sites in Britain for evidence of trade in body parts and whether this can be elucidated by a parallel stable isotope study of modern fallow antlers of known provenance

" 'Riveted Mounts' Reconsidered : Horn Composite Combs in Early Medieval Britain, Ireland and France"

International audienc

" 'Riveted Mounts' Reconsidered : Horn Composite Combs in Early Medieval Britain, Ireland and France"

International audienc

" 'Riveted Mounts' Reconsidered : Horn Composite Combs in Early Medieval Britain, Ireland and France"

International audienc