Industrial Brush Coiler Attachment

Problem Statement: Company initially desired a new machine that would be able to produce external coiled brushes that would help in increasing revenue and project opportunities. The design has shifted to making an attachment to the existing equipment that would help in this effort instead of developing a completely new unit. Rationale: Sealeze sees this as an opportunity of increasing revenue and also taking on the effort of making externally coiled brushes more efficiently. If successful, more clients can be taken in and it would make Sealeze a more versatile company. Approach: The main approach revolved around weekly meetings with Sealeze. E-mail was utilized daily in order to make sure that the desire of the company were met. There were at least three different iterations to the design until one was settled upon. Main design tool used was SolidWorks and the design model was shown to the company frequently. Interim Results and Conclusions: The main problems that were of concern revolved around the amount of force needed to bend the brush and in a circular fashion. Calculations were done to insure that the brush would be bent with the right amount of force when also taking into consideration the motor driven components that were guiding the brush. Anticipated Results and Conclusions: According to the calculations, it is expected that the brush will not buckle while the machine is running and will be able to formed into the desired spiral.https://scholarscompass.vcu.edu/capstone/1059/thumbnail.jp

Black hole scaling relations of active and quiescent galaxies: Addressing selection effects and constraining virial factors

Local samples of quiescent galaxies with dynamically measured black hole masses (Mbh) may suffer from an angular resolution-related selection effect, which could bias the observed scaling relations between Mbh and host galaxy properties away from the intrinsic relations. In particular, previous work has shown that the observed Mbh-Mstar (stellar mass) relation is more strongly biased than the Mbh-sigma (velocity dispersion) relation. Local samples of active galactic nuclei (AGN) do not suffer from this selection effect, as in these samples Mbh is estimated from megamasers and/or reverberation mapping-based techniques. With the exception of megamasers, Mbh-estimates in these AGN samples are proportional to a virial coefficient fvir. Direct modelling of the broad line region suggests that fvir~3.5. However, this results in a Mbh-Mstar relation for AGN which lies below and is steeper than the one observed for quiescent black hole samples. A similar though milder trend is seen for the Mbh-sigma relation. Matching the high-mass end of the Mbh-Mstar and Mbh-sigma relations observed in quiescent samples requires fvir~15 and fvir~7, respectively. On the other hand, fvir~3.5 yields Mbh-sigma and Mbh-Mstar relations for AGN which are remarkably consistent with the expected `intrinsic' correlations for quiescent samples (i.e., once account has been made of the angular resolution-related selection effect), providing additional evidence that the sample of local quiescent black holes is biased. We also show that, as is the case for quiescent black holes, the Mbh-Mstar scaling relation of AGN is driven by velocity dispersion, thus providing additional key constraints to black hole-galaxy co-evolution models.Comment: 15 pages, 5 Figures. MNRAS, accepte

THE OPTICAL-UV EMISSIVITY OF QUASARS: DEPENDENCE ON BLACK HOLE MASS AND RADIO LOUDNESS

We analyzed a large sample of radio-loud and radio-quiet quasar spectra at redshift 1.0 < z < 1.2 to compare the inferred underlying quasar continuum slopes (after removal of the host galaxy contribution) with accretion disk models. The latter predict redder (decreasing) alpha_3000 continuum slopes (L_\nu~\nu^alpha at 3000Ang) with increasing black hole mass, bluer alpha_3000 with increasing luminosity at 3000Ang, and bluer alpha_3000 with increasing spin of the black hole, when all other parameters are held fixed. We find no clear evidence for any of these predictions in the data. In particular we find that: (i) alpha_3000 shows no significant dependence on black hole mass or luminosity. Dedicated Monte Carlo tests suggest that the substantial observational uncertainties in the black hole virial masses can effectively erase any intrinsic dependence of alpha_3000 on black hole mass, in line with some previous studies. (ii) The mean slope alpha_3000 of radio-loud sources, thought to be produced by rapidly spinning black holes, is comparable to, or even redder than, that of radio-quiet quasars. Indeed, although quasars appear to become more radio loud with decreasing luminosity, we still do not detect any significant dependence of alpha_3000 on radio loudness. The predicted mean alpha_3000 slopes tend to be bluer than in the data. Disk models with high inclinations and dust extinction tend to produce redder slopes closer to empirical estimates. Our mean alpha_3000 values are close to the ones independently inferred at z<0.5 suggesting weak evolution with redshift, at least for moderately luminous quasars.This is the author accepted manuscript. The final version is available from the Institute of Physics via http://dx.doi.org/10.3847/2041-8205/818/1/L

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

The evolution of lung cancer and impact of subclonal selection in TRACERx

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource

The evolution of non-small cell lung cancer metastases in TRACERx

Metastatic disease is responsible for the majority of cancer-related deaths. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse