The 43GHz SiO maser in the circumstellar envelope of the AGB star R Cassiopeiae

We present multi-epoch, total intensity, high-resolution images of 43GHz, v=1, J=1-0 SiO maser emission toward the Mira variable R Cas. In total we have 23 epochs of data for R Cas at approximate monthly intervals over an optical pulsation phase range from 0.158 to 1.78. These maps show a ring-like distribution of the maser features in a shell, which is assumed to be centred on the star at a radius of 1.6 to 2.3 times the stellar radii. It is clear from these images that the maser emission is significantly extended around the star. At some epochs a faint outer arc can be seen at 2.2 stellar radii. The intensity of the emission waxes and wanes during the stellar phase. Some maser features are seen infalling as well as outflowing. We have made initial comparisons of our data with models by Gray et. al. (2009).Comment: 12 pages, 14 figure

BAL and non-BAL quasars: Continuum, emission, and absorption properties establish a common parent sample

Using a sample of $\simeq$144,000 quasars from the Sloan Digital Sky Survey data release 14 we investigate the outflow properties, evident both in absorption and emission, of high-ionization Broad Absorption Line (BAL) and non-BAL quasars with redshifts 1.6 $\lesssim z \leq$ 3.5 and luminosities 45.3 $< \log_{10}(L_{bol}) <$ 48.2 erg s$^{-1}$. Key to the investigation is a continuum and emission-line reconstruction scheme, based on mean-field independent component analysis, that allows the kinematic properties of the CIV$\lambda$1550 emission line to be compared directly for both non-BAL and BAL quasars. CIV-emission blueshift and equivalent-width (EW) measurements are thus available for both populations. Comparisons of the emission-line and BAL-trough properties reveal strong systematic correlations between the emission and absorption properties. The dependence of quantitative outflow indicators on physical properties such as quasar luminosity and luminosity relative to Eddington-luminosity are also shown to be essentially identical for the BAL and non-BAL populations. There is an absence of BALs in quasars with the hardest spectral energy distributions (SEDs), revealed by the presence of strong HeII$\lambda$1640 emission, large CIV$\lambda$1550-emission EW and no measurable blueshift. In the remainder of the CIV-emission blueshift versus EW space, BAL and non-BAL quasars are present at all locations; for every BAL-quasar it is possible to identify non-BAL quasars with the same emission-line outflow properties and SED-hardness. The co-location of BAL and non-BAL quasars as a function of emission-line outflow and physical properties is the key result of our investigation, demonstrating that (high-ionization) BALs and non-BALs represent different views of the same underlying quasar population

Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition

Missense and truncating variants in the X-chromosome-linked CLCN4 gene, resulting in reduced or complete loss-of-function (LOF) of the encoded chloride/proton exchanger ClC-4, were recently demonstrated to cause a neurocognitive phenotype in both males and females. Through international clinical matchmaking and interrogation of public variant databases we assembled a database of 90 rare CLCN4 missense variants in 90 families: 41 unique and 18 recurrent variants in 49 families. For 43 families, including 22 males and 33 females, we collated detailed clinical and segregation data. To confirm causality of variants and to obtain insight into disease mechanisms, we investigated the effect on electrophysiological properties of 59 of the variants in Xenopus oocytes using extended voltage and pH ranges. Detailed analyses revealed new pathophysiological mechanisms: 25% (15/59) of variants demonstrated LOF, characterized by a shift of the voltage-dependent activation to more positive voltages, and nine variants resulted in a toxic gain-of-function, associated with a disrupted gate allowing inward transport at negative voltages. Functional results were not always in line with in silico pathogenicity scores, highlighting the complexity of pathogenicity assessment for accurate genetic counselling. The complex neurocognitive and psychiatric manifestations of this condition, and hitherto under-recognized impacts on growth, gastrointestinal function, and motor control are discussed. Including published cases, we summarize features in 122 individuals from 67 families with CLCN4-related neurodevelopmental condition and suggest future research directions with the aim of improving the integrated care for individuals with this diagnosis

Contribution of encouraging the future use of biomethane to resolving sustainability and energy security challenges: The case of the UK

The focus of this research is the potential of biomethane in Britain's gas grid. It examines its relative ability to address Britain's sustainability and energy security challenges from an economic perspective. Such research is important because UK is wedded to gas for heat production and power generation and is increasingly dependent on imported gas, in line with shrinking domestic production, and uncertain future trading relationships. Also, dependency on natural gas, threatens Britain achieving its legally-binding carbon budgets. The study included a thorough literature review, primary research to finally uncover the views of key UK market participants plus analytical modelling. The findings reveal that the market is cautiously optimistic, despite reservations regarding feedstock availability and the impending cessation of subsidy approvals. Investors are in greater need of long-term certainty, however, and the challenge of decarbonising heat and heavy-duty transport warrants this. Retail price premiums are polarised but, in line with wholesale costs, relatively high compared to electricity. The key recommendation is for the policymakers to follow precedents in renewable electricity and liquid biofuels, by mandating that energy suppliers, owners of heavy-duty road fleets and occupiers of new buildings purchase biomethane. In tandem, feedstock and grid-entry restrictions must be tackled creatively

Tacit rejection of policy and teacher ambivalence – insights into English language teaching in Bahrain through actors’ perceptions

This article develops Phillips and Ochs's (2003) framework for policy borrowing, particularly their theorisations about indigenisation of international programmes. It uses the example of communicative language teaching (CLT) in Bahrain, exploring teacher perspectives regarding the effects of CLT on the preexisting arrangements in the national education system and the impact of contextual factors on the potential for CLT implementation. The author conducted qualitative focus groups with English language teachers in 10 schools. The analysis elucidates how teachers were tailoring their own ways through the new reforms to strike a satisfactory balance between the government's aims and the attitudes of the public. It answers the question, "What happens to English language teaching policy when it is transplanted to a different culture?" and concludes that it becomes actively rejected. The conclusion offers a conceptual development of Phillips and Ochs's framework, adding the option of rejection to the indigenisation stage. The article ends with some practical implications

HIV and drug abuse mediate astrocyte senescence in a β‐catenin‐dependent manner leading to neuronal toxicity

Emerging evidence suggests that cell senescence plays an important role in aging‐associated diseases including neurodegenerative diseases. HIV leads to a spectrum of neurologic diseases collectively termed HIV‐associated neurocognitive disorders (HAND). Drug abuse, particularly methamphetamine (meth), is a frequently abused psychostimulant among HIV+ individuals and its abuse exacerbates HAND. The mechanism by which HIV and meth lead to brain cell dysregulation is not entirely clear. In this study, we evaluated the impact of HIV and meth on astrocyte senescence using in vitro and several animal models. Astrocytes constitute up to 50% of brain cells and play a pivotal role in marinating brain homeostasis. We show here that HIV and meth induce significant senescence of primary human fetal astrocytes, as evaluated by induction of senescence markers (β‐galactosidase and p16INK 4A), senescence‐associated morphologic changes, and cell cycle arrest. HIV‐ and meth‐mediated astrocyte senescence was also demonstrated in three small animal models (humanized mouse model of HIV/NSG‐huPBMCs, HIV‐transgenic rats, and in a meth administration rat model). Senescent astrocytes in turn mediated neuronal toxicity. Further, we show that β‐catenin, a pro‐survival/proliferation transcriptional co‐activator, is downregulated by HIV and meth in human astrocytes and this downregulation promotes astrocyte senescence while induction of β‐catenin blocks HIV‐ and meth‐mediated astrocyte senescence. These studies, for the first time, demonstrate that HIV and meth induce astrocyte senescence and implicate the β‐catenin pathway as potential therapeutic target to overcome astrocyte senescence

Mitochondrial DNA signals of late glacial recolonization of Europe from near Eastern refugia

Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and the East European Plain (U4 and U5a). Parts of the Near East, such as the Levant, were also continuously inhabited throughout the Last Glacial Maximum, but unlike western and eastern Europe, no archaeological or genetic evidence for Late Glacial expansions into Europe from the Near East has hitherto been discovered. Here we report, on the basis of an enlarged whole-genome mitochondrial database, that a substantial, perhaps predominant, signal from mitochondrial haplogroups J and T, previously thought to have spread primarily from the Near East into Europe with the Neolithic population, may in fact reflect dispersals during the Late Glacial period, ?19–12 thousand years (ka) ago.<br/