2,105 research outputs found
Assessing the Challenges to a Geosynchronous Space Tug System
A space tug vehicle is designed to rendezvous and dock with a space object; make an assessment of its current position,
orientation, and operational status; and then either stabilize the object in its current orbit or move the object to a new
location with subsequent release. A subset of on-orbit servicing, space tug missions in the geosynchronous belt include
stationkeeping of satellites which have lost attitude control and repositioning of satellites. Repositioning of spacecraft
may be desirable as a means to rescue satellites launched into incorrect orbits, for the retirement of satellites into
“graveyard” orbits, and for on-demand maneuvers that support flexible mission requirements. This paper aims to unify
the political, legal, operational, and financial aspects of the space tug concept and highlight the challenges that stand in
the way of an operational space tug vehicle. U.S. Space Transportation Policy is reviewed, and a space tug operation is
recognized as an enabler of emerging national space transportation requirements. Customary international and United
States laws are explored as potential constraining forces on future tug missions. A concept of operations in
geosynchronous orbit, including parking orbit selection and approach strategies, is analyzed with emphasis placed on
safety and reliability. Potential financing models and the issue of insurance for space tugs are discussed and identified as
the principal challenges facing implementation of a space tug system. This paper offers a positive forecast for the future
of on-orbit servicing and endorses continued government support for proof-of-concept missions
Technical Note: Field experiences using UV/VIS sensors for high-resolution monitoring of nitrate in groundwater
peer-reviewedTwo different in situ spectrophotometers are compared that were used in the field to determine nitrate-nitrogen (NO3-N) concentrations at two distinct spring discharge sites. One sensor was a double wavelength spectrophotometer (DWS) and the other a multiple wavelength spectrophotometer (MWS). The objective of the study was to review the hardware options, determine ease of calibration, accuracy, influence of additional substances and to assess positive and negative aspects of the two sensors as well as troubleshooting and trade-offs. Both sensors are sufficient to monitor highly time-resolved NO3-N concentrations in emergent groundwater. However, the chosen path length of the sensors had a significant influence on the sensitivity and the range of detectable NO3-N. The accuracy of the calculated NO3-N concentrations of the sensors can be affected if the content of additional substances such as turbidity, organic matter, nitrite or hydrogen carbonate significantly varies after the sensors have been calibrated to a particular water matrix. The MWS offers more possibilities for calibration and error detection but requires more expertise compared with the DWS.The authors would like to acknowledge
the Teagasc Walsh Fellowship scheme for funding the study in Ireland, and the German federal Ministry of Education and Research (BMBF) for sponsoring the SMART-project (grant
no. 02WM1079-1086, 02WM1211-1212) for the study in Jordan.Teagasc Walsh Fellowship Programm
Mobilisation or dilution? Nitrate response of karst springs to high rainfall events
peer-reviewedNitrate (NO3−) contamination of groundwater associated with agronomic activity is of major concern in many countries. Where agriculture, thin free draining soils and karst aquifers coincide, groundwater is highly vulnerable to nitrate contamination. As residence times and denitrification potential in such systems are typically low, nitrate can discharge to surface waters unabated. However, such systems also react quickest to agricultural management changes that aim to improve water quality. In response to storm events, nitrate concentrations can alter significantly, i.e. rapidly decreasing or increasing concentrations. The current study examines the response of a specific karst spring situated on a grassland farm in South Ireland to rainfall events utilising high-resolution nitrate and discharge data together with on-farm borehole groundwater fluctuation data. Specifically, the objectives of the study are to formulate a scientific hypothesis of possible scenarios relating to nitrate responses during storm events, and to verify this hypothesis using additional case studies from the literature. This elucidates the controlling key factors that lead to mobilisation and/or dilution of nitrate concentrations during storm events. These were land use, hydrological condition and karstification, which in combination can lead to differential responses of mobilised and/or diluted nitrate concentrations. Furthermore, the results indicate that nitrate response in karst is strongly dependent on nutrient source, whether mobilisation and/or dilution occur and on the pathway taken. This will have consequences for the delivery of nitrate to a surface water receptor. The current study improves our understanding of nitrate responses in karst systems and therefore can guide environmental modellers, policy makers and drinking water managers with respect to the regulations of the European Union (EU) Water Framework Directive (WFD). In future, more research should focus on the high-resolution monitoring of karst aquifers to capture the high variability of hydrochemical processes, which occur at time intervals of hours to days.Teagasc Walsh Fellowship Programm
Coincident observations by the Kharkiv IS radar and ionosonde, DMSP and Arase (ERG) satellites, and FLIP model simulations: implications for the NRLMSISE-00 hydrogen density, plasmasphere, and ionosphere
This paper reports the results of ionosphere and plasmasphere observations with the Kharkiv incoherent scatter radar and ionosonde, Defense Meteorological Satellite Program, and Arase (ERG) satellites and simulations with field line interhemispheric plasma model during the equinoxes and solstices of solar minimum 24. The results reveal the need to increase NRLMSISE-00 thermospheric hydrogen density by a factor of ~2. For the first time, it is shown that the measured plasmaspheric density can be reproduced with doubled NRLMSISE-00 hydrogen density only. A factor of ~2 decrease of plasmaspheric density in deep inner magnetosphere (L ˜ 2.1) caused by very weak magnetic disturbance (Dst > 22 nT) of 24 December 2017 was observed in the morning of 25 December 2017. During the next night, prominent effects of partially depleted flux tube were observed in the topside ionosphere (~50% reduced H+ ion density) and at the F2-layer peak (~50% decreased electron density). The likely physical mechanisms are discussed.Peer ReviewedPostprint (published version
Secular Variations of Atomic Oxygen in the Mesopause Region Induced by Transient Gravity Wave Packets
We employ a 2-dimensional, time-dependent, fully nonlinear model of minor species in the mesopause region and our Spectral Full-Wave Model to simulate the response of atomic oxygen (O) to a gravity wave packet in the mesopause region. We demonstrate that gravity waves affect the time-averaged distribution of O in the mesosphere and lower thermosphere (MLT) region through the constituent fluxes the waves induce. Our conclusions are based on simulations of two wave packets that violate the non-acceleration conditions through transience and dissipation. The net cycle-averaged effect of the waves is to significantly increase (by as much as 50%) the O density through downward transport of O at low altitudes (≤90 km), and to deplete (by as much as 20%) the O density above ∼100 km altitude. Comparison with results obtained including only chemistry and diffusion suggests that the effects of gravity wave transport on the distribution of O in this region can be greater than the effects of eddy transport
Weak magnetic storms can modulate ionosphere-plasmasphere interaction significantly: mechanisms and manifestations at mid-latitudes
A comprehensive study of the response of the ionosphere-plasmasphere system at mid-latitudes to weak (Dstmin > -50 nT) magnetic storms is presented. For the first time, it is shown that weak magnetic disturbances can lead to significant modulation of ionosphere-plasmasphere H+ ion fluxes. It is found that this modulation is caused by the enhancements/reductions of the topside O+ ion density, which is induced by F2-layer peak height rise and fall during the storms. The F2-layer motion is caused by thermospheric wind changes and by a penetration electric field. Both drivers are closely related to the changes in the Bz component of interplanetary magnetic field. The most prominent manifestation of the H+ ion flux modulation is strong changes in H+ ion fraction in the topside ionosphere. This study also indicates that the NRLMSISE-00 model provides the correct relative changes of neutral H density during weak magnetic storms and also that there is a compelling need to include geomagnetic activity indices, in addition to solar activity (F10.7), as input parameters to empirical topside ionosphere models.Peer ReviewedPostprint (published version
Photometric Catalogue of Quasars and Other Point Sources in the Sloan Digital Sky Survey
We present a catalogue of about 6 million unresolved photometric detections
in the Sloan Digital Sky Survey Seventh Data Release classifying them into
stars, galaxies and quasars. We use a machine learning classifier trained on a
subset of spectroscopically confirmed objects from 14th to 22nd magnitude in
the SDSS {\it i}-band. Our catalogue consists of 2,430,625 quasars, 3,544,036
stars and 63,586 unresolved galaxies from 14th to 24th magnitude in the SDSS
{\it i}-band. Our algorithm recovers 99.96% of spectroscopically confirmed
quasars and 99.51% of stars to i 21.3 in the colour window that we study.
The level of contamination due to data artefacts for objects beyond is
highly uncertain and all mention of completeness and contamination in the paper
are valid only for objects brighter than this magnitude. However, a comparison
of the predicted number of quasars with the theoretical number counts shows
reasonable agreement.Comment: 16 pages, Ref. No. MN-10-2382-MJ.R2, accepted for publication in
MNRAS Main Journal, April 201
Grazers and diggers: exploitation competition and coexistence among foragers with different feeding strategies on a single resource
A mathematical model is presented that describes a system where two consumer species compete exploitatively for a single renewable resource. The resource is distributed in a patchy but homogeneous environment; that is, all patches are intrinsically identical. The two consumer species are referred to as diggers and grazers, where diggers deplete the resource within a patch to lower densities than grazers. We show that the two distinct feeding strategies can produce a heterogeneous resource distribution that enables their coexistence. Coexistence requires that grazers must either move faster than diggers between patches or convert the resources to population growth much more efficiently than diggers. The model shows that the functional form of resource renewal within a patch is also important for coexistence. These results contrast with theory that considers exploitation competition for a single resource when the resource is assumed to be well mixed throughout the system.Shane A. Richards, Roger M. Nisbet, William G. Wilson, and Hugh P. Possingha
Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial
Background:
Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis.
Methods:
In this phase 3, double-blind, placebo-controlled study undertaken at 76 centres in Asia, Australia, Canada, Europe, and the USA, adults (aged ≥18 years old) with active psoriatic arthritis were randomly allocated in a 1:1:1:1 ratio with computer-generated blocks to receive subcutaneous placebo or secukinumab 300 mg, 150 mg, or 75 mg once a week from baseline and then every 4 weeks from week 4. Patients and investigators were masked to treatment assignment. The primary endpoint was the proportion of patients achieving at least 20% improvement in the American College of Rheumatology response criteria (ACR20) at week 24. Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01752634.
Findings:
Between April 14, and Nov 25, 2013, 397 patients were randomly assigned to receive secukinumab 300 mg (n=100), 150 mg (n=100), 75 mg (n=99), or placebo (n=98). A significantly higher proportion of patients achieved an ACR20 at week 24 with secukinumab 300 mg (54 [54%] patients; odds ratio versus placebo 6·81, 95% CI 3·42–13·56; p<0·0001), 150 mg (51 [51%] patients; 6·52, 3·25–13·08; p<0·0001), and 75 mg (29 [29%] patients; 2·32, 1·14–4·73; p=0·0399) versus placebo (15 [15%] patients). Up to week 16, the most common adverse events were upper respiratory tract infections (four [4%], eight [8%], ten [10%], and seven [7%] with secukinumab 300 mg, 150 mg, 75 mg, and placebo, respectively) and nasopharyngitis (six [6%], four [4%], six [6%], and eight [8%], respectively). Serious adverse events were reported by five (5%), one (1%), and four (4%) patients in the secukinumab 300 mg, 150 mg, and 75 mg groups, respectively, compared with two (2%) in the placebo group. No deaths were reported.
Interpretation:
Subcutaneous secukinumab 300 mg and 150 mg improved the signs and symptoms of psoriatic arthritis, suggesting that secukinumab is a potential future treatment option for patients with this disorder
Development of a single-board computer high-resolution microendoscope (PiHRME) to increase access to cervical cancer screening in underserved areas
Over 85% of cervical cancer deaths occur in developing countries.1 Even though the early detection and treatment of cervical precancerous lesions has been shown to prevent invasive cervical cancer, limited resources make it difficult to implement standard cervical cancer screening methods, such as the Pap Smear, in low-resource areas. Instead, many developing countries rely on the visual inspection of the cervix with acetic acid (VIA) to help identify precancerous and cancerous lesions. While VIA has a high sensitivity (82.14%), it has a poor specificity (50.00%), resulting in the overtreatment of women and misallocation of limited resources.2 Recent studies have shown that combining VIA with high-resolution microendoscope (HRME) imaging increases the specificity of cervical cancer screening.3-4 The HRME is a low-cost imaging system (~$2,100) that allows the user to image epithelial tissue in vivo at sub-cellular resolutions at the point-of-care. The current HRME imaging system is also accompanied with automatic image analysis software to distinguish normal and low-grade lesions from high-grade precancerous and cancerous lesions of the cervix.
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