Assessing the effectiveness of micro-spring technology to reduce initial and peak loading rates when integrated into running footwear

Running has long been one of the world’s most popular recreational activities. The current total of European runners exceeds 80 million, approximately, 36% of 15�65-year-old European population. Running is one of the most widespread activities during which overuse injuries of the lower extremity occur (Hreljac, 2004). It has been estimated that up to 70% of runners will sustain an overuse injury during any one year period (Caspersen et al., 1984). Previous work has shown that impact forces and high loading rates are linked to injury rates in runners (Davis, Bowser, & Mullineaux, 2010). Despite the apparent advances in footwear technology and the plethora footwear choices available, we are yet to see a reduction in injury rates amongst runners

Bridging the theoretical gap: The Diasporized Hybrid in Sociological Theory

In a nation of immigrants, most American ethnic groups have at some point wrestled with how to reconcile having an identity that is rooted simultaneously in their countries of origin and in the United States, particularly when they are also racialized ethnic minorities. This hybrid identity often blends divergent cultures and traditions. And sociologists, intent on explaining these tensions, have focused on the experiences that have shaped these identities for over a century. As a result, the theoretical roots of contemporary hybridity theories such as the segmented assimilation perspective, can be traced back to “classical” theorists of race, pluralism, and identity such as Robert Park, Horace Kallen, and W.E.B. Dubois. This chapter examines these roots, with the exception of DuBois’s theories of double consciousness (found in Chapter 2) to provide a holistic sociological account of theories of hybrid identities. We suggest that despite the changing nature of immigrant experiences today due to globalization, there is still significant continuity between the processes and outcomes of ethnic identity formation among 19th and 20th century European immigrants and the more racially and ethnically diverse post-1965 immigrants to the United States

Pinpointing Why Object Recognition Performance Degrades Across Income Levels and Geographies

Despite impressive advances in object-recognition, deep learning systems' performance degrades significantly across geographies and lower income levels raising pressing concerns of inequity. Addressing such performance gaps remains a challenge, as little is understood about why performance degrades across incomes or geographies. We take a step in this direction by annotating images from Dollar Street, a popular benchmark of geographically and economically diverse images, labeling each image with factors such as color, shape, and background. These annotations unlock a new granular view into how objects differ across incomes and regions. We then use these object differences to pinpoint model vulnerabilities across incomes and regions. We study a range of modern vision models, finding that performance disparities are most associated with differences in texture, occlusion, and images with darker lighting. We illustrate how insights from our factor labels can surface mitigations to improve models' performance disparities. As an example, we show that mitigating a model's vulnerability to texture can improve performance on the lower income level. We release all the factor annotations along with an interactive dashboard to facilitate research into more equitable vision systems

Severity of Pain is not associated with Urgency of Diagnosis in ED Patients with Abdominal Pain

Background Abdominal Pain is the most common cause of visits to US Emergency Departments (EDs) and the causes range from urgent to non-urgent diagnoses. Distinguishing urgent versus non-urgent causes of abdominal pain is done through the use of clinical exam, lab studies and diagnostic imaging such as CT scans. There are no validated clinical decision rules to assist physicians in discriminating urgent from non-urgent causes of abdominal pain or which patient needs a CT scan. There is controversy regarding the use of CT scans for patients with abdominal pain due to the increased cost, radiation exposure and length of stay. Objective The objective of this study is to compare the demographics, pain score and CT utilization for patients with urgent versus non-urgent causes of abdominal pain. Methods At an academic ED, a convenience sample of patients with abdominal pain was prospectively enrolled by research assistants during the ED visit. Research assistants abstracted treatment information from the electronic medical record for the ED and hospitalization if applicable. Finally, enrollees were telephoned 2 weeks after the index ED visit to ascertain symptom resolution and treatment outcomes. Following establishment of final diagnosis, patients were classified as having an urgent or non-urgent diagnosis based upon published peer-reviewed criteria. Risk differences in pain severity, CT scan utilization and demographics were compared to urgency of diagnosis and a paired t-test was used to estimate differences in initial clinical characteristics. Results In a model of 725 patients, 144 had urgent diagnoses and 561 had non-urgent diagnoses. There was no distinction in insurance type, income level, mean age or pain score in the two groups. Ct scan utilization was higher in patients with urgent diagnoses (42.4% versus 16.4%.) Conclusion 20.4% of patients had an urgent diagnosis for the abdominal pain. There was no difference in the pain score for patients with urgent versus non-urgent diagnosis. While work-up bias is a potential limitation, CT scan utilization was higher in patients with an urgent diagnosis suggesting appropriate clinical judgement. Future studies will need to look at ways to target the testing to more high-risk patients who present with undifferentiated abdominal pain

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

Cancer associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on targeting the proliferation of rapidly growing cancer epithelial cells. We know that this is largely ineffective with resistance arising in most tumors following exposure to chemotherapy. Despite the long-standing recognition of the prominence of CAFs in PDAC, the effect of chemotherapy on CAFs and how they may contribute to drug resistance in neighboring cancer cells is not well characterized. Here we show that CAFs exposed to chemotherapy play an active role in regulating the survival and proliferation of cancer cells. We found that CAFs are intrinsically resistant to gemcitabine, the chemotherapeutic standard of care for PDAC. Further, CAFs exposed to gemcitabine significantly increase the release of extracellular vesicles called exosomes. These exosomes increased chemoresistance-inducing factor, Snail, in recipient epithelial cells and promote proliferation and drug resistance. Finally, treatment of gemcitabine-exposed CAFs with an inhibitor of exosome release, GW4869, significantly reduces survival in co-cultured epithelial cells, signifying an important role of CAF exosomes in chemotherapeutic drug resistance. Collectively, these findings show the potential for exosome inhibitors as treatment options alongside chemotherapy for overcoming PDAC chemoresistance

Walking for our health: couple-focused interventions to promote physical activity in older adults

More than 50% of U.S. adults do not engage in sufficient physical activity to meet current recommendations, making physical activity change and maintenance a priority for health promotion throughout adulthood. Among married partners, change in physical activity of one partner often is concordant with change of activity of the other. The primary purpose of this study was to examine two couple-focused interventions that capitalize on the co-occurrence of health behavior change within couples to promote physical activity in older adults. In this study, partners (N = 31 couples) participated together in assessment and intervention activities, and were randomized together into one of two couple-focused conditions. In one condition (concurrent), standard goal-setting techniques were extended to a couple-focused design with each partner setting daily step goals and monitoring her or his own progress. In the other condition (combined), partners collaborated to set and monitor shared daily step goals. Physical activity was assessed with accelerometers pre- and post-intervention. Post-intervention, average weekly physical activity increased by 58 min (p \u3c 0.001), and average body mass index (BMI) decreased by 0.50 kg/m2 (p = 0.001), from pre-intervention measures. Similar levels of change in weekly physical activity and in BMI were detected in both intervention groups. Furthermore, participants demonstrated high adherence to the intervention protocol. Results suggest that couple-focused physical activity interventions can be effective in eliciting increases in physical activity among older adults. Further research is needed to uncover interpersonal mechanisms that maximize physical activity promotion and maintenance within couples over time

Frequency of reporting on patient and public involvement (PPI) in research studies published in a general medical journal : a descriptive study

Objectives While documented plans for patient and public involvement (PPI) in research are required in many grant applications, little is known about how frequently PPI occurs in practice. Low levels of reported PPI may mask actual activity due to limited PPI reporting requirements. This research analysed the frequency and types of reported PPI in the presence and absence of a journal requirement to include this information. Design and setting A before and after comparison of PPI reported in research papers published in The BMJ before and 1 year after the introduction of a journal policy requiring authors to report if and how they involved patients and the public within their papers. Results Between 1 June 2013 and 31 May 2014, The BMJ published 189 research papers and 1 (0.5%) reported PPI activity. From 1 June 2015 to 31 May 2016, following the introduction of the policy, The BMJ published 152 research papers of which 16 (11%) reported PPI activity. Patients contributed to grant applications in addition to designing studies through to coauthorship and participation in study dissemination. Patient contributors were often not fully acknowledged; 6 of 17 (35%) papers acknowledged their contributions and 2 (12%) included them as coauthors. Conclusions Infrequent reporting of PPI activity does not appear to be purely due to a failure of documentation. Reporting of PPI activity increased after the introduction of The BMJ ’s policy, but activity both before and after was low and reporting was inconsistent in quality. Journals, funders and research institutions should collaborate to move us from the current situation where PPI is an optional extra to one where PPI is fully embedded in practice throughout the research process

CRISPR provides acquired resistance against viruses in prokaryotes

Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophage. We found that following viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus, CRISPR, together with associated cas genes, provided resistance against phages, whereby specificity is determined by spacer/phage sequence similarity

A Community Narration Assessment of Master's Level Psychology Students at Antioch University Los Angeles

Applied Community Psychology (ACP) is a specialty field of study in the Master’s of Arts in Clinical Psychology (MAP) at Antioch University Los Angeles (AULA).  Students participate in classes and workshops that present theory along with opportunities for real life application.  In the Spring 2019 quarter, eight students were enrolled in a Community Narration (CN) approach workshop to learn the theory and practice of facilitating the CN.  The students used CN to discover commonalities and differences in their experiences as students of AULA.  They created a community narrative which expressed the culture of students at AULA.  In addition, the students learned how to conduct CN in the community with application in program evaluation and consultation.  A discussion of the results of the community narrative that emerged is described, and implications for faculty and administrators are presented