311 - Sibling Dyads’ Perceptions of Their Relationship in Adolescence and Early Adulthood

As part of a longitudinal study, we examined siblings’ perceptions of their relationship in adolescence and early adulthood. Twenty-five sibling dyads completed questionnaires about their relationship during adolescence and early adulthood. The adolescent questionnaire was an age-adjusted questionnaire developed for use in the study; it included five scales (Asymmetry, Intimacy, Prosocial/Harmony, Relational Aggression, and Conflict). For the early adulthood phase, we used the Adult Sibling Relationship Questionnaire (Stocker et al., 1997); it included 12 scales (Similarity, Intimacy, Quarreling, Affection, Antagonism, Admiration, Emotional Support, Competition, Instrumental Support, Domination, Acceptance, and Knowledge). Correlations among scales on the questionnaires reveal considerable coherence in the sibling relationships at both ages and some continuity between adolescence and early adulthood. On the adolescent questionnaire, siblings showed strong agreement on their ratings of the amount of prosocial behavior/harmony and conflict in their relationship. They disagreed in their ratings of the asymmetry, intimacy, and relational aggression in their relationship. In early adulthood, siblings agreed on their ratings of similarity, intimacy, quarreling, antagonism, domination, and acceptance; they differed in their ratings of affection, admiration, emotional support, competition, instrumental support, and knowledge. For both siblings at both ages, many of the positive dimensions were positively intercorrelated and the negative dimensions were positively intercorrelated. At both ages, the positive scales and the negative scales were negatively intercorrelated. The adult scales of Instrumental Support and Competition were not consistently correlated with either positive or negative dimensions; we suspect that this may suggest a difference for brothers and sisters

The Ursinus Weekly, February 5, 1945

Banquet, ball top memories of past for record crowd • Sororities adopt rules regulating rush season • Dramatic group to present Night Must Fall ; Florence Cherry, Warren Jenkins are leads • Y holds retreat to plan activities • College board reveals changes in calendar • WSGA open big business at games • Rev. Adams addresses college church groups • YMCA elects Chiaravalloti to head campus organizations • Lombardo to feature new sentimental song • Miss Snell is on advisory board for health pamphlet in library • What will be the future of foreign trade? • Coeds convert losing halftime score to 24-23 win over women marines, here • Wrestlers, basketeers defeat Swarthmore teams Wednesday • Lafayette swamps bears, 61-39, in contest at Easton Saturday • Post-war draft is discussion topic for entire nation • Canterbury Club sponsors informal dance at meeting • Early birds organize Sunday breakfast club • Dr. McClure to speak at Hood • Chaplain is guest speaker • Lutherans hear Rev. Schantzhttps://digitalcommons.ursinus.edu/weekly/1698/thumbnail.jp

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter

Mutations in the Plasmodium falciparum ‘chloroquine resistance transporter’ (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transportthese drugs away from their targets within the parasite’s digestive vacuole (DV). However, CQ resistance-conferring isoforms of PfCRT (PfCRTCQR) also render the parasite hypersensitive to a subset of structurally-diverse pharmacons. Moreover, mutations in PfCRTCQR that suppress the parasite’s hypersensitivity to these molecules simultaneously reinstate its sensitivity to CQ and related drugs. We sought to understand these phenomena by characterizing the functions of PfCRTCQR isoforms that cause the parasite to become hypersensitive to the antimalarial quinine or the antiviral amantadine. We achieved this by measuring the abilities of these proteins to transport CQ, quinine, and amantadine when expressed in Xenopus oocytes and complemented this work with assays that detect the drug transport activity of PfCRT in its native environment within the parasite. Here we describe two mechanistic explanations for PfCRT-induced drug hypersensitivity. First, we show that quinine, which normally accumulates inside the DV and therewithin exerts its antimalarial effect, binds extremely tightly to the substrate-binding site of certain isoforms of PfCRTCQR. By doing so it likely blocks the normal physiological function of the protein, which is essential for the parasite’s survival, and the drug thereby gains an additional killing effect. In the second scenario, we show that although amantadine also sequesters within the DV, the parasite’s hypersensitivity to this drug arises from the PfCRTCQR-mediated transport of amantadine from the DV into the cytosol, where it can better access its antimalarial target. In both cases, the mutations that suppress hypersensitivity also abrogate the ability of PfCRTCQR to transport CQ, thus explaining why rescue from hypersensitivity restores the parasite’s sensitivity to this antimalarial. These insights provide a foundation for understanding clinically-relevant observations of inverse drug susceptibilities in the malaria parasite

Minding the gap: The importance of active facilitation in moving boundary objects from in-theory to in-use as a tool for knowledge mobilisation

The Health Inequalities Assessment Toolkit (HIAT) was developed to support those involved in health research to integrate a focus on health inequalities. Our study focuses on bringing together the concepts of boundary objects (BO) and brokers-as-bricoleurs to explain the implementation of the HIAT within a research capacity building programme. Exploring the extent to which (i) the HIAT operated as a BO and (ii) the ideal conditions to nurture and enhance its effectiveness during knowledge mobilisation. We employed a qualitative approach to analyse: semi-structured focus groups and telephone interviews; secondary data from an evaluation of the wider research programme within which the capacity building was situated. Data was thematically analysed incorporating the properties of a BO: meaningfulness, convergence, resonance and authenticity. Four main themes identified: (1) Generating convergence through creating a focus (2) Reconciling differences to create a common language (3) Workshop facilitators: boundary brokers-as-bricoleurs, (4) Thoughts into action. The HIAT operated as a BO, enabling individuals across the different project teams to galvanise around the issue of health inequalities, explore collaboratively and incorporate equity within service evaluations. Highlighting the importance of involving brokers with an ability to improvise and mobilise around the HIAT, using their expertise to translate and interpret across boundaries and emphasise shared goals. Reflecting on this, a modified tool with additional resources beyond socio-economic causes has been launched as a forum to consider health inequalities from diverse perspectives for use beyond UK health and social care research

Affective Experiences of International and Home Students during the Information Search Process

An increasing number of students are studying abroad requiring that they interact with information in languages other than their mother tongue. The UK in particular has seen a large growth in international students within Higher Education. These non-native English speaking students present a distinct user group for university information services, such as university libraries. This article presents the findings from an in-depth study to understand differences between the search processes of home and international students. Data were collected using an online survey and diary-interview to capture thoughts and feelings in a more naturalistic way. International students are found to have similar information search processes to those of home students, but sometimes face additional difficulties in assessing search results such as confusion when dealing with differing cultural perspectives. The potential implications for information service providers, particularly university libraries, are discussed, such as providing assistance to students for identifying appropriate English sources

Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum

Disruption of the potassium/chloride cotransporter 3 (KCC3), encoded by the SLC12A6 gene, causes hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder affecting both the peripheral nervous system and CNS. However, the precise role of KCC3 in the maintenance of ion homeostasis in the nervous system and the pathogenic mechanisms leading to HMSN/ACC remain unclear. We established two Slc12a6 Cre/LoxP transgenic mouse lines expressing C-terminal truncated KCC3 in either a neuron-specific or ubiquitous fashion. Our results suggest that neuronal KCC3 expression is crucial for axon volume control. We also demonstrate that the neuropathic features of HMSN/ACC are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression. Furthermore, we demonstrate that KCC3 plays an essential role in inflammatory pain pathways. Finally, we observed hypoplasia of the corpus callosum in both mouse mutants and a marked decrease in axonal tracts serving the auditory cortex in only the general deletion mutant. Together, these results establish KCC3 as an important player in both central and peripheral nervous system maintenance

Two Components of Long-Distance Extraction: Successive Cyclicity in Dinka

This article presents novel data from the Nilotic language Dinka, in which the syntax of successive-cyclic movement is remarkably transparent. We show that Dinka provides strong support for the view that long-distance extraction proceeds through the edge of every verb phrase and every clause on the path of movement (Chomsky 1986, 2000, 2001, 2008). In addition, long-distance dependencies in Dinka offer evidence that extraction from a CP requires agreement between v and the CP that is extracted from (Rackowski and Richards 2005, Den Dikken 2009b, 2012a,b). The claim that both of these components constrain long-distance movement is important, as much contemporary work on extraction incorporates only one of them. To accommodate this conclusion, we propose a modification of Rackowski and Richards 2005, in which both intermediate movement and Agree relations between phase heads are necessary steps in establishing a long-distance dependency

Abstracts from the NIHR INVOLVE Conference 2017

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