Jerwood Contemporary Makers 2010

Jerwood Contemporary Makers showcases work by the new generation of UK makers. Selected by Hans Stofer (chair), Richard Slee and myself, the exhibition investigates the notion of making by bringing together a broad range of work from across craft and the visual arts. Twenty-nine makers took part, each exhibiting one work and receiving an equal share of the £30,000 prize fund. Supported by the Jerwood Charitable Foundation. A catalogue in the form a newspaper broadsheet was produced with an essay, ‘The Making Game’ commissioned from Jeanette Winterson. A series of Monday evening events accompanied the exhibition. These included Emmanuel Cooper (ceramicist and craft writer) in conversation with Hans Stofer, Richard Slee and myself also a panel discussion exploring the notion of amateur making, chaired by Stephen Knott, (PhD student, School of Applied Art, RCA) with the research student that I supervise Emma Shercliff, (PhD student, School of Fashion & Textiles, RCA). At the National Craft Gallery, Kilkenny, Ireland I conducted a gallery tour and delivered a lecture and workshop on Curating Contemporary Craft alongside curator David Littler. The exhibition received considerable press including Crafts, July/August 2010 (Dr.Jessica Hemmings), Design Week, 27 May 2010 and The Independent, 29 June 2010 (Michael Glover)

A proof of Bell\u27s inequality in quantum mechanics using causal interactions

We give a simple proof of Bell\u27s inequality in quantum mechanics which, in conjunction with experiments, demonstrates that the local hidden variables assumption is false. The proof sheds light on relationships between the notion of causal interaction and interference between particles

Impact of community based peer support in type 2 diabetes: a cluster randomised controlled trial of individual and/or group approaches

Background: Diabetes peer support, where one person with diabetes helps guide and support others, has been proposed as a way to improve diabetes management. We have tested whether different diabetes peer support strategies can improve metabolic and/or psychological outcomes.<p></p> Methods: People with type 2 diabetes (n=1,299) were invited to participate as either ‘peer’ or ‘peer support facilitator’ (PSF) in a 2x2 factorial pragmatic randomised cluster controlled trial across rural communities (130 clusters) in England. Peer support was delivered over 8-12 months by trained PSFs, supported by monthly meetings with a diabetes educator. Primary end point was HbA1c. Secondary outcomes included quality of life, diabetes distress, blood pressure, waist, total cholesterol and weight. Outcome assessors and investigators were masked to arm allocation. Main factors were 1:1 or group intervention. Analysis was by intention-to-treat adjusting for baseline.<p></p> Results: The 4 arms were well matched (Group n=330, 1:1 n=325, combined n=322, control n=322); 1035 (79·7%) completed the mid-point postal questionnaire and 1064 (81·9%) had a final HbA1c. A limitation was that although 92.6% PSFs and peers were in telephone contact, only 61.4% of intervention participants attended a face to face session.<p></p> Mean baseline HbA1c was 57 mmol/mol (7·4%), with no significant change across arms. Systolic blood pressure was reduced by -2·3mm Hg (-4·0 to -0·6) among those allocated group peer-support and -3·0mm Hg (-5·0 to -1·1) among those who attended group peer-support at least once. There was no impact on other outcomes by intention to treat or significant differences between arms in self-reported adherence or medication.<p></p> Conclusions: Group diabetes peer support over 8-12 months was associated with a small improvement in blood pressure but no other benefits. Long term benefits should be investigated

Using Administrative Data to Explore the Effect of Survey Nonresponse in the UK Employment Retention and Advancement Demonstration

Background: Even a well-designed randomized control trial (RCT) study can produce ambiguous results. This paper highlights a case in which full-sample results from a large-scale RCT in the United Kingdom (UK) differ from results for a sub-sample of survey respondents. Objectives: Our objective is to ascertain the source of the discrepancy in inferences across data sources and, in doing so, to highlight important threats to the reliability of the causal conclusions derived from even the strongest research designs. Research design: The study analyzes administrative data to shed light on the source of the differences between the estimates. We explore the extent to which heterogeneous treatment impacts and survey non-response might explain these differences. We suggest checks which assess the external validity of survey measured impacts, which in turn provides an opportunity to test the effectiveness of different weighting schemes to remove bias. The Subjects included 6,787 individuals who participated in a large-scale social policy experiment. Results: Our results were not definitive but suggest non-response bias is the main source of the inconsistent findings. Conclusions. The results caution against overconfidence in drawing conclusions from RCTs and highlight the need for great care to be taken in data collection and analysis. Particularly, given the modest size of impacts expected in most RCTs, small discrepancies in data sources can alter the results. Survey data remain important as a source of information on outcomes not recorded in administrative data. However, linking survey and administrative data is strongly recommended whenever possible

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implicated in SBMA; however, the extent to which altered AR transcriptional function contributes to pathogenesis remains controversial. Here, we sought to dissociate effects of diminished AR function from polyQ-mediated proteotoxicity by enhancing the transcriptional activity of polyQ AR. To accomplish this, we bypassed the inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutating conserved lysines in the polyQ AR that are sites of SUMOylation. We determined that replacement of these residues by arginine enhances polyQ AR activity as a hormone-dependent transcriptional regulator. In a murine model, disruption of polyQ AR SUMOylation rescued exercise endurance and type I muscle fiber atrophy; it also prolonged survival. These changes occurred without overt alterations in polyQ AR expression or aggregation, revealing the favorable trophic support exerted by the ligand-activated receptor. Our findings demonstrate beneficial effects of enhancing the transcriptional function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may be a potential target for therapeutic intervention in SBMA

The benefits of self-esteem: Reply to Krueger et al. (2022) and Brummelman (2022)

Krueger et al. (2022) argue that our review (Orth & Robins, 2022) finds benefits of self-esteem primarily for subjective outcomes and largely fails to demonstrate any "objective" benefits. We disagree with this portrayal of the findings and highlight research that provides evidence for the benefits of self-esteem using objective measures. We also address Krueger et al.'s claim that positivity bias in self-reports can account for the effects of self-esteem on subjectively assessed life outcomes, and explain how the statistical analyses used to document these effects substantially control for this bias. We maintain that there is now a large body of evidence from meta-analyses and large-scale longitudinal studies demonstrating that high self-esteem has adaptive consequences for social relationships, school, work, mental health, physical health, and antisocial behavior. Brummelman (2022) presents a compelling theoretical framework that can guide the design of interventions to improve children's self-esteem. We agree with his concerns about the need for randomized controlled trials to evaluate the efficacy of self-esteem interventions and the importance of ensuring that children's self-esteem can be raised without causing them to become narcissistic. The research reviewed in our article indicates that high self-esteem is adaptive for children, adolescents, and adults, suggesting that well-designed and effective self-esteem interventions might be beneficial for individuals of all ages. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

Is high self-esteem beneficial? Revisiting a classic question

Debates about the benefits of self-esteem have persisted for decades, both in the scientific literature and in the popular press. Although many researchers and lay people have argued that high self-esteem helps individuals adapt to and succeed in a variety of life domains, there is widespread skepticism about this claim. The present article takes a new look at the voluminous body of research (including several meta-analyses) examining the consequences of self-esteem for several important life domains: relationships, school, work, mental health, physical health, and antisocial behavior. Overall, the findings suggest that self-esteem is beneficial in all these domains, and that these benefits hold across age, gender, and race/ethnicity, and controlling for prior levels of the predicted outcomes and potential third variable confounds. The meta-analytic estimates of self-esteem effects (which average .10 across domains) are comparable in size to estimates for other hypothesized causal factors such as self-efficacy, positive emotionality, attachment security, and growth mindset, and larger than some generally accepted pharmaceutical interventions. Discussion focuses on several issues that are critical for evaluating the findings, including the strength of the evidence for making causal inferences, the magnitude of the effects, the importance of distinguishing between self-esteem and narcissism, and the generalizability of the results. In summary, the present findings support theoretical conceptions of self-esteem as an adaptive trait that has wide-ranging influences on healthy adjustment and adaptation, and suggest that interventions aimed at boosting self-esteem might, if properly designed and implemented, benefit individuals and society as a whole. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

Investigating the global dispersal of chickens in prehistory using ancient mitochondrial dna signatures

Data from morphology, linguistics, history, and archaeology have all been used to trace the dispersal of chickens from Asian domestication centers to their current global distribution. Each provides a unique perspective which can aid in the reconstruction of prehistory. This study expands on previous investigations by adding a temporal component from ancient DNA and, in some cases, direct dating of bones of individual chickens from a variety of sites in Europe, the Pacific, and the Americas. The results from the ancient DNA analyses of forty-eight archaeologically derived chicken bones provide support for archaeological hypotheses about the prehistoric human transport of chickens. Haplogroup E mtDNA signatures have been amplified from directly dated samples originating in Europe at 1000 B.P. and in the Pacific at 3000 B.P. indicating multiple prehistoric dispersals from a single Asian centre. These two dispersal pathways converged in the Americas where chickens were introduced both by Polynesians and later by Europeans. The results of this study also highlight the inappropriate application of the small stretch of D-loop, traditionally amplified for use in phylogenetic studies, to understanding discrete episodes of chicken translocation in the past. The results of this study lead to the proposal of four hypotheses which will require further scrutiny and rigorous future testingExcavations in Fais by MI were made possible by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. DB gratefully acknowledges support from the Marsden Fund, and the Allan Wilson Centre for Molecular Ecology and Evolution. During the course of this research AS was supported by a Postgraduate Scholarship from the University of Auckland and a Fellowship from the Allan Wilson Centre for Molecular Ecology and Evolutio