16 research outputs found

    Moving from talk to action on Africa’s climate change adaptation

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    During COP26, the LSE Firoz Lalji Institute for Africa asked leading thinkers and practitioners on Africa and climate change how the continent should best adapt to potentially severe, and already evident, environmental changes. Dr Richard Munang, Africa Regional Climate Change Coordinator at the UN Environment Programme, outlines five key areas

    Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

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    BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

    A strategic approach and business model for scaling up ecosystem-based adaptation for sustainable development in Africa

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    Chapter 10 considers ecosystem-based adaptation and CSA as new paradigms that offer an integrated solution to maximizing the productivity of agriculture and food systems under changing climate regimes. The author posits that ecosystem-based adaptation and CSA offer an opportunity to break from traditional approaches and the silos that have limited the capacity for improving the food security condition of many.PRIFPRI1; ReSAKSS; IFPRI4; A Ensuring Sustainable food production; E Building ResilienceWCA

    Climate Change in Africa

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    A Public Lecture by Dr. Richard Munang, the UNEP Climate Change Coordinator for Africa on Thursday April 9th at the USIU - Africa Auditoriu

    Ecosystem Management: Tomorrow’s Approach to Enhancing Food Security under a Changing Climate

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    This paper argues that a sustainable ecosystem management approach is vital to ensure the delivery of essential ‘life support’ ecosystem services and must be mainstreamed into societal conscience, political thinking and economic processes. Feeding the world at a time of climate change, environmental degradation, increasing human population and demand for finite resources requires sustainable ecosystem management and equitable governance. Ecosystem degradation undermines food production and the availability of clean water, hence threatening human health, livelihoods and ultimately societal stability. Degradation also increases the vulnerability of populations to the consequences of natural disasters and climate change impacts. With 10 million people dying from hunger each year, the linkages between ecosystems and food security are important to recognize. Though we all depend on ecosystems for our food and water, about seventy per cent of the estimated 1.1 billion people in poverty around the world live in rural areas and depend directly on the productivity of ecosystems for their livelihoods. Healthy ecosystems provide a diverse range of food sources and support entire agricultural systems, but their value to food security and sustainable livelihoods are often undervalued or ignored. There is an urgent need for increased financial investment for integrating ecosystem management with food security and poverty alleviation priorities. As the world’s leaders worked towards a new international climate change agenda in Cancun, Mexico, 29 November–10 December 2010 (UNFCCC COP16), it was clear that without a deep and decisive post-2012 agreement and major concerted effort to reduce the food crisis, the Millennium Development Goals will not be attained. Political commitment at the highest level will be needed to raise the profile of ecosystems on the global food agenda. It is recommended that full recognition and promotion be given of the linkages between healthy, protected ecosystems and global food security; that sufficient resources be allocated for improved ecosystem valuation, protection, management and restoration; and that ecosystem management be integrated in climate change and food security portfolios. We will not be able to feed the world and eradicate extreme poverty, if we do not protect our valuable ecosystems and biodiversity

    Using Small-Scale Adaptation Actions to Address the Food Crisis in the Horn of Africa: Going beyond Food Aid and Cash Transfers

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    The countries Kenya, Uganda, Somalia, Ethiopia and Djibouti are facing the worst food crisis of the 21st century as a result of devastating droughts. The crisis is causing starvation and leading to a lack of access to clean water and sanitation for over 12 million people. Not only are the direct drought effects endured now by the population, but they have weakened response capacity and created diminished prospects of ever achieving future water and food security. Over the coming decades, temperatures in this region will continue to rise and rainfall patterns will change. This will create major problems for food production and availability. Thus, building resilience in communities is indispensable as we adapt our farming systems to the challenges of climate change. This will require practical solutions that can build on processes involving adaptation to climate change. The lessons learned from the UN-led project in Uganda, demonstrate the value of small scale innovative interventions, carried out using democratic approaches to help support adaptation to climate change whilst progressing to achieve food security and chart a new Path to eliminate hunger. These lessons should be our guiding vision as we address the current droughts plaguing the Horn of East Africa and elsewhere

    Using Small-Scale Adaptation Actions to Address the Food Crisis in the Horn of Africa: Going beyond Food Aid and Cash Transfers

    No full text
    The countries Kenya, Uganda, Somalia, Ethiopia and Djibouti are facing the worst food crisis of the 21st century as a result of devastating droughts. The crisis is causing starvation and leading to a lack of access to clean water and sanitation for over 12 million people. Not only are the direct drought effects endured now by the population, but they have weakened response capacity and created diminished prospects of ever achieving future water and food security. Over the coming decades, temperatures in this region will continue to rise and rainfall patterns will change. This will create major problems for food production and availability. Thus, building resilience in communities is indispensable as we adapt our farming systems to the challenges of climate change. This will require practical solutions that can build on processes involving adaptation to climate change. The lessons learned from the UN-led project in Uganda, demonstrate the value of small scale innovative interventions, carried out using democratic approaches to help support adaptation to climate change whilst progressing to achieve food security and chart a new Path to eliminate hunger. These lessons should be our guiding vision as we address the current droughts plaguing the Horn of East Africa and elsewhere.climate change adaptation; small scale solutions; food security

    Ecosystem Management: Tomorrow’s Approach to Enhancing Food Security under a Changing Climate

    No full text
    This paper argues that a sustainable ecosystem management approach is vital to ensure the delivery of essential ‘life support’ ecosystem services and must be mainstreamed into societal conscience, political thinking and economic processes. Feeding the world at a time of climate change, environmental degradation, increasing human population and demand for finite resources requires sustainable ecosystem management and equitable governance. Ecosystem degradation undermines food production and the availability of clean water, hence threatening human health, livelihoods and ultimately societal stability. Degradation also increases the vulnerability of populations to the consequences of natural disasters and climate change impacts. With 10 million people dying from hunger each year, the linkages between ecosystems and food security are important to recognize. Though we all depend on ecosystems for our food and water, about seventy per cent of the estimated 1.1 billion people in poverty around the world live in rural areas and depend directly on the productivity of ecosystems for their livelihoods. Healthy ecosystems provide a diverse range of food sources and support entire agricultural systems, but their value to food security and sustainable livelihoods are often undervalued or ignored. There is an urgent need for increased financial investment for integrating ecosystem management with food security and poverty alleviation priorities. As the world’s leaders worked towards a new international climate change agenda in Cancun, Mexico, 29 November–10 December 2010 (UNFCCC COP16), it was clear that without a deep and decisive post-2012 agreement and major concerted effort to reduce the food crisis, the Millennium Development Goals will not be attained. Political commitment at the highest level will be needed to raise the profile of ecosystems on the global food agenda. It is recommended that full recognition and promotion be given of the linkages between healthy, protected ecosystems and global food security; that sufficient resources be allocated for improved ecosystem valuation, protection, management and restoration; and that ecosystem management be integrated in climate change and food security portfolios. We will not be able to feed the world and eradicate extreme poverty, if we do not protect our valuable ecosystems and biodiversity

    Ecosystem Management: Tomorrow’s Approach to Enhancing Food Security under a Changing Climate

    No full text
    This paper argues that a sustainable ecosystem management approach is vital to ensure the delivery of essential ‘life support’ ecosystem services and must be mainstreamed into societal conscience, political thinking and economic processes. Feeding the world at a time of climate change, environmental degradation, increasing human population and demand for finite resources requires sustainable ecosystem management and equitable governance. Ecosystem degradation undermines food production and the availability of clean water, hence threatening human health, livelihoods and ultimately societal stability. Degradation also increases the vulnerability of populations to the consequences of natural disasters and climate change impacts. With 10 million people dying from hunger each year, the linkages between ecosystems and food security are important to recognize. Though we all depend on ecosystems for our food and water, about seventy per cent of the estimated 1.1 billion people in poverty around the world live in rural areas and depend directly on the productivity of ecosystems for their livelihoods. Healthy ecosystems provide a diverse range of food sources and support entire agricultural systems, but their value to food security and sustainable livelihoods are often undervalued or ignored. There is an urgent need for increased financial investment for integrating ecosystem management with food security and poverty alleviation priorities. As the world’s leaders worked towards a new international climate change agenda in Cancun, Mexico, 29 November–10 December 2010 (UNFCCC COP16), it was clear that without a deep and decisive post-2012 agreement and major concerted effort to reduce the food crisis, the Millennium Development Goals will not be attained. Political commitment at the highest level will be needed to raise the profile of ecosystems on the global food agenda. It is recommended that full recognition and promotion be given of the linkages between healthy, protected ecosystems and global food security; that sufficient resources be allocated for improved ecosystem valuation, protection, management and restoration; and that ecosystem management be integrated in climate change and food security portfolios. We will not be able to feed the world and eradicate extreme poverty, if we do not protect our valuable ecosystems and biodiversity.food security; climate change; ecosystem management; ecosystem services; biodiversity; Millennium Development Goals; poverty
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