Harvey Cushing: early use of tendon transfers for repair of foot deformity: A historical case report

We describe 4 cases of tendon transfers for correction of foot deformities, which were performed by Harvey Cushing in 1898

The changing paradigm of ethics in uterus transplantation: a systematic review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154399/1/tri13548_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154399/2/tri13548.pd

Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate

Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures using conditional logistic regression models. While no single nucleotide polymorphism (SNP) achieved genome-wide significance when considered alone, markers in SLC2A9 and the neighboring WDR1 on chromosome 4p16.1 gave suggestive evidence of gene-environment interaction with environmental tobacco smoke (ETS) among 259 Asian trios when the models included a term for GxE interaction. Multiple SNPs in these two genes were associated with increased risk of nonsyndromic CP if the mother was exposed to ETS during the peri-conceptual period (3 months prior to conception through the first trimester). When maternal ETS was considered, fifteen of 135 SNPs mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance (10-6<P<10-4) in a test for GxETS interaction. SNPs rs3733585 and rs12508991 in SLC2A9 yielded P = 2.26×10-7 in a test for GxETS interaction. SNPs rs6820756 and rs7699512 in WDR1 also yielded P = 1.79×10-7 and P = 1.98×10-7 in a 1 df test for GxE interaction. Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest SLC2A9 and WDR1 should be considered as candidate genes for CP. © 2014 Wu et al

Conventional surgical techniques and emerging transplantation in complex penile reconstruction

Complex penile reconstruction continues to pose a significant challenge to surgeons and patients alike. The ideal phalloplasty is one that can be reproducibly performed in a single stage, creates a neourethra that allows for voiding while standing, produces a phallus with tactile and erogenous sensation, allows for penetrative sexual intercourse, and offers satisfactory aesthetic results. With recent advances in microsurgery and perforator flap dissection, several techniques and modifications thereof have been described that aim to achieve these reconstructive goals. All of these now conventional techniques, however, fall short in one way or another - often with regards to urinary transport, the ability to achieve an erection, and the need for multiple surgical stages and revision operations. These limitations of conventional reconstruction have led some surgeons to explore new avenues for complex penis reconstruction, giving birth to the novel field of penile transplantation. In this article, we discuss the complexities of male genitourinary reconstruction in the context of conventional methods for reconstruction as well as the burgeoning field of penile transplantation

Pediatric Tissue Expansion: Predictors of Premature Expander Removal in a Single Surgeon\u27s Experience with 472 Expanders.

BACKGROUND: Tissue expansion is used for soft-tissue reconstruction in pediatric patients. The expansion process can be complicated by infection and extrusion, leading to premature expander removal. The aim of this study was to identify risk factors associated with premature expander removal caused by infection or extrusion in pediatric patients. METHODS: A retrospective study of pediatric patients who underwent tissue expansion performed by the senior author (R.J.R.) over a 12-year period was performed. Predictor variables included age, sex, race, indication, anatomical location, number of expanders, serial expansion, and expander size. Bivariate and multivariate analyses were performed to identify risk factors for premature expander removal. RESULTS: A total of 139 patients with 472 expanders were included in this study. Complications occurred with 78 expanders (16.5 percent). Premature expander removal caused by infection or exposure occurred with 51 expanders (10.8 percent). In terms of location, the highest rates of premature removal occurred in the lower extremity (20.0 percent) and scalp (16.3 percent). Multivariate analysis identified younger age (0 to 6 years compared with 13 to 17 years; OR, 3.98; 95 percent CI, 1.13 to 14.08; p = 0.03), greater number of expanders (OR, 1.45; 95 percent CI, 1.03 to 2.03; p = 0.03), and lower extremity location (OR, 4.27; 95 percent CI, 1.45 to 12.53; p = 0.008) were associated with an increased odds of premature expander removal. CONCLUSIONS: Expander removal occurred in approximately 10 percent of tissue expanders. Odds of premature removal is increased with younger age, greater number of expanders, and lower extremity location. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III

What Is the Impact of Postoperative Antibiotic Prophylaxis on Tissue Expander Infection Rates in Pediatric Patients?

BACKGROUND: Tissue expansion in the pediatric population can be complicated by high rates of infection and extrusion. The aim of this study was to examine the impact of postoperative antibiotic prophylaxis on infectious complications. METHODS: A retrospective study of all pediatric patients who underwent tissue expander insertion at a children\u27s hospital over a 12-year period was performed. Predictor variables included age, sex, race, indication, anatomical location, number of expanders inserted, serial expansion, history of infection or extrusion, and postoperative antibiotics. Outcome variables included infection and extrusion. Bivariate and multivariate analyses were performed to identify factors associated with infection and/or extrusion. RESULTS: A total of 180 patients who underwent 317 operations for tissue expander insertion were included in this study. Postoperative infection and/or extrusion occurred after 73 operations (23 percent). Postoperative prophylactic antibiotics were prescribed after 232 operations (75 percent), and only perioperative (≤24 hours) antibiotics were administered in 85 cases (25 percent). There were no significant differences in the rate of infection (12.1 percent versus 8.9 percent; p = 0.46), extrusion (16.8 percent versus 17.7 percent; p = 0.88), or infection and/or extrusion (23.7 percent versus 24.1 percent; p = 0.95) between these two groups. Multivariate analysis revealed that postoperative antibiotics did not have a significant association with infection and/or extrusion (OR, 0.84; 95 percent CI, 0.44 to 1.63; p = 0.61). CONCLUSIONS: The rates of infection/extrusion were similar between pediatric patients who received only perioperative antibiotics (≤24 hours) and those who were prescribed a course of postoperative antibiotics. Based on these results, a course of postoperative prophylactic antibiotics may be unnecessary after insertion of tissue expanders in pediatric patients. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III

The Ethics of Penis Transplantation: A Systematic Review

Purpose: We conducted this systematic review to document ethical concerns regarding human penis allotransplantation and how these concerns have changed over time. Methods: We searched six databases (MEDLINE via PubMed, Embase, CINAHL, Scopus, Web of Science, and Google Scholar) from inception to November 9, 2018 to find articles addressing ethical concerns related to penis allotransplantation. Inclusion criteria were articles written in English on the topic of penis allotransplantation that discussed at least one bioethical principle. Data was extracted and categorized into the four bioethical pillars: autonomy, beneficence, nonmaleficence, and justice. We assessed theme frequency by publication year and temporal trends. A sub-analysis of the Bioethical pillars and themes specifically addressing the first penis transplantation case performed in 2006 were extracted and evaluated separately. Results:Search results yielded 142 citations. Thirty-nine articles were eligible and included in the final data extraction and analysis. Publication years were 2006 through 2018 with an average of 3 publications per year (range: 0 to 12). The most frequently addressed bioethical pillar was nonmaleficence with themes included in 37 of 39 articles (95%), followed by beneficence (36 of 39, 92%), justice (32 of 39, 82%), and autonomy (29 of 39, 74%). Top concerns pertaining to nonmaleficence included the risk-benefit ratio (n=30, 81%) and risks of long-term immunosuppression (n=29, 78%). Top concerns regarding beneficence included restoration of bodily function, integrity, or aesthetics (n=33, 92) and improved QOL (n=25, 69%). Top concerns pertaining to justice included patient selection (n=25, 78%), burden to donor family, and impact on deceased donor solid organ donation (n=13, 41%). Top concerns regarding autonomy included patient informed consent (n=18, 62%), and donor or donor family informed consent (n=16, 55%). Bioethical issues in reference to the 2006 case were mentioned in 29 of 39 articles (74%); nonmaleficence was most often addressed, mentioned in 27 of 29 articles (93%). Conclusions: Penis transplantation has been a topic of much ethical debate. During the 12-year study period, nonmaleficence was the most common recurring ethical pillar with the two most common themes being risks and benefits for undergoing the procedure and the need for life-long immunosuppression. The first attempt in 2006 that resulted in the graft being removed greatly influenced the field of penis transplantation