International Economic Agreements and the Constitution

International agreements, such as the General Agreement on Tariffs and Trade (GATT) and the North American Free Trade Agreement (NAFTA), generally aim to facilitate the free flow of goods and services among nations.1 The U.S. Supreme Court has developed a jurisprudence similarly aiming to facilitate the free flow of goods and services among the several states. That jurisprudence has developed from litigation challenging the constitutionality of state actions on the basis of the Commerce and Supremacy Clauses of the Constitution (art. I, § 8, cl. 3, and art. VI, cl. 2). In some subject areas, Commerce Clause decisions closely align with international agreements. In other areas, either or both fall short of achieving economic integration.

2016 AQ Summit: Innovation Update by Richard Frost

An overview of the Maritime Applied Physics Corporation and its initiatives. Includes a summary of MAPC\u27s opportunities to contribute to the development of Maine\u27s aquaculture industry

Land Grant Application- Frost, Richard (Marblehead)

Land grant application submitted to the Maine Land Office for Richard Frost for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_mass/1140/thumbnail.jp

High resolution astronomical imaging through the turbulent atmosphere

technical reportThis research is principally concerned with the digital reconstruction of star images observed with large ground-based telescopes, although the techniques developed here will have application to a broad class of reconstruction problems. Since the work of Labeyrie, the difficulty in producing accurate and detailed reconstructions of stars has stemmed primarily from the extreme degradation of the phase spectrum caused by the atmospheric turbulence, and secondarily from the low-pass filter characteristic of the telescope itself. In this research, we describe solutions to both problems. Our phase estimator is based on the Knox-Thompson phase difference estimator, which we have extended and modified to produce more accurate estimates. The performance of this estimator is evaluated by simulation at various signal-to-noise ratios. We also describe a new non-linear super-resolution algorithm which appears to exhibit the best accuracy and convergence characteristics of any such algorithm proposed to date. It is also evaluated empirically. These two techniques were then used to restore images of the stars Betelgeuse and Capella. In the latter restoration resolution is realized well beyond the diffraction-limit of the telescope. Both reconstructions are consistent with known astrophysical facts, and both appear to be of high quality

Personalising medicine : feasibility and future implications from a payers' perspective

There are considerable differences in how patients respond to treatments due to a number of factors calling for personalised approaches to care, which is happening. However, the early promise of personalised medicine has not always translated into improved care for patients. Payers have concerns that current tests can be costly, requests for funding specific tests have subsequently been reversed as more information becomes available, and there is currently fragmentation in the funding of diagnostic tests. Payers also have concerns that pharmaceutical companies are exploiting the situation by seeking orphan status for their new targeted medicines driving up requested prices. It is also not clear who should fund biomarkers that accompany new expensive medicines. This is changing as the cost of tests come down, and payers develop new models to optimise the managed entry of new medicines as well as evaluate potential prices for new medicines for orphan diseases. There are also developments with ‘big data’ offering new understanding of disease complexity to enhance pipeline productivity and diagnosis as well as ongoing developments with drug resistance testing and research into the role of microbiomes to improve future health. Current challenges and concerns are being addressed. This will continue to improve patient care