Analysis of turbine stator adjustment required for compressor design-point operation in high Mach number supersonic turbojet engines

For turbojet engines designed for flight Mach numbers of 2.5 and 3.0, use of turbine stator adjustment to maintain compressor design-point operation was evaluated analytically to determine the effect on the aerodynamics of the turbine. Since the effect of turbine stator adjustment is to make the turbine design sensitive to the particular engine design conditions selected, in some cases the turbine must be conservatively designed for the high-speed flight condition to assure satisfactory turbine performance at take-off. A new concept, the break-even point, is introduced to provide quick evaluation of the proximity of turbines to the blade-loading limit at any off-design operation

One-dimensional analysis of choked-flow turbines

Flow conditions internal to choked-flow turbines were subjected to a one-dimensional analysis. Factors affecting the design, operation, and manufacture of such turbines were investigated. Criteria are presented which will aid in analysis of test data from such turbines. The effect of turbine-stator adjustment on internal flow conditions was investigated for one application of turbine stator adjustment

The Proteus Navier-Stokes code

An effort is currently underway at NASA Lewis to develop two- and three-dimensional Navier-Stokes codes, called Proteus, for aerospace propulsion applications. The emphasis in the development of Proteus is not algorithm development or research on numerical methods, but rather the development of the code itself. The objective is to develop codes that are user-oriented, easily-modified, and well-documented. Well-proven, state-of-the-art solution algorithms are being used. Code readability, documentation (both internal and external), and validation are being emphasized. This paper is a status report on the Proteus development effort. The analysis and solution procedure are described briefly, and the various features in the code are summarized. The results from some of the validation cases that have been run are presented for both the two- and three-dimensional codes

Anti-HER2 IgY antibody-functionalized single-walled carbon nanotubes for detection and selective destruction of breast cancer cells

BACKGROUND: Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells and HER2-negative MCF-7 cells. METHODS: The complex was constructed by covalently conjugating carboxylated SWNTs with anti-HER2 chicken IgY antibody, which is more specific and sensitive than mammalian IgGs. Raman signals were recorded on Raman spectrometers with a laser excitation at 785 nm. NIR irradiation was performed using a diode laser system, and cells with or without nanotube treatment were irradiated by 808 nm laser at 5 W/cm(2 )for 2 min. Cell viability was examined by the calcein AM/ethidium homodimer-1 (EthD-1) staining. RESULTS: Using a Raman optical microscope, we found the Raman signal collected at single-cell level from the complex-treated SK-BR-3 cells was significantly greater than that from various control cells. NIR irradiation selectively destroyed the complex-targeted breast cancer cells without harming receptor-free cells. The cell death was effectuated without the need of internalization of SWNTs by the cancer cells, a finding that has not been reported previously. CONCLUSION: We have demonstrated that the HER2 IgY-SWNT complex specifically targeted HER2-expressing SK-BR-3 cells but not receptor-negative MCF-7 cells. The complex can be potentially used for both detection and selective photothermal ablation of receptor-positive breast cancer cells without the need of internalization by the cells. Thus, the unique intrinsic properties of SWNTs combined with high specificity and sensitivity of IgY antibodies can lead to new strategies for cancer detection and therapy

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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NACA Research Memorandums

From Introduction: "Because of the lack of data on compressor characteristics at 130 or 145 percent of design equivalent rotational speed, several simplifying assumptions were made regarding the compressor characteristics during operation at equivalent rotational speeds above the design value (hereinafter called "compressor overspeeding"). In addition to results based on these assumptions, the effect of deviation from these assumptions is discussed.

NACA Research Memorandums

From Introduction: "An investigation of the variation in turbine-entrance equivalent weight flow for a two-stage turbine equipped with an adjustable turbine stator is presented in reference 1. A general analytical investigation of turbine stator adjustment is presented in reference 2. In reference 2, the effect of stator adjustment on turbine off-design performance is also investigated by analytically computing the performance of a particular single-stage turbine.

NACA Research Memorandums

Empirical methods of Ainley and Kochendorfer and Nettles were used to predict performances of nine turbine designs. Measured and predicted performances were compared. Appropriate values of blade-loss parameter were determined for the method of Kochendorfer and Nettles. The measured design-point efficiencies were lower than predicted by as much as 0.09 (Ainley and 0.07 (Kochendorfer and Nettles)