Averaging the Assessments of Multiple Judges: Applications to Clinical Assessment and Research

This is an abstract of a paper that investigates the utility of a simple equation that predicts the expected validity coefficient for any given composite size

Initial Helioseismic Observations by Hinode/SOT

Results from initial helioseismic observations by Solar Optical Telescope onboard Hinode are reported. It has been demonstrated that intensity oscillation data from Broadband Filter Imager can be used for various helioseismic analyses. The k-omega power spectra, as well as corresponding time-distance cross-correlation function that promises high-resolution time-distance analysis below 6-Mm travelling distance, were obtained for G-band and CaII-H data. Subsurface supergranular patterns have been observed from our first time-distance analysis. The results show that the solar oscillation spectrum is extended to much higher frequencies and wavenumbers, and the time-distance diagram is extended to much shorter travel distances and times than they were observed before, thus revealing great potential for high-resolution helioseismic observations from Hinode.Comment: 6 pages, accepted for publication in PAS

Development of extinction imagers for the determination of atmospheric optical extinction: final report

The primary goals of this project for JTO and ONR (Grant N00014-07-1-1060) were to further develop Extinction Imagers for use in the ocean environment, and to extend the capabilities into the Short Wave IR (SWIR). Extinction Imaging is a method for determining the effective extinction coefficient over an extended path using a sensor at one end of the path. It uses calibrated imagers to acquire the relative radiance of a dark target near the other the end of the path and the horizon sky in the direction of the dark target. It is completely passive and thus covert, and the hardware is robust and relatively inexpensive. It uses rigorous equations, which determine the extinction coefficient from the measured apparent contrast of the radiance of the dark target with respect to the horizon sky. The project was very successful. We found that the ocean surface could readily be used as a dark target in red and SWIR wavelengths. Both the red and the SWIR measurement results were excellent for daytime. Comparisons with standard instruments, as well as uncertainty analysis, indicated that extinction imagers provide better measurements of the atmospheric extinction losses over extended paths than other methods of which we are aware. Our secondary goals were to address the night regime, and to address slanted paths above the horizontal. Regarding night, we found that the visible sensor acquired excellent data, but the ocean surface was not a good dark target in our wavelengths. Recommendations on the handling of night are given in the report. Regarding the lines of sight above the horizon, we developed a slant path algorithm that determines beam transmittance. It performed very well. Recommendations are made regarding integration of these techniques for military applications.Joint Technology Office via Office of Naval ResearchGrant N00014-07-1-106

A Radial Velocity Study of Composite-Spectra Hot Subdwarf Stars with the Hobby-Eberly Telescope

Many hot subdwarf stars show composite spectral energy distributions indicative of cool main sequence companions. Binary population synthesis (BPS) models demonstrate such systems can be formed via Roche lobe overflow or common envelope evolution but disagree on whether the resulting orbital periods will be long (years) or short (days). Few studies have been carried out to assess the orbital parameters of these spectroscopic composite binaries; current observations suggest the periods are long. To help address this problem, we selected fifteen moderately-bright (V~13) hot subdwarfs with F-K dwarf companions and monitored their radial velocities (RVs) from January 2005 to July 2008 using the bench-mounted Medium Resolution Spectrograph on the Hobby-Eberly Telescope (HET). Here we describe the details of our observing, reduction, and analysis techniques and present preliminary results for all targets. By combining the HET data with recent observations from the Mercator telescope, we are able to calculate precise orbital solutions for three systems using more than 6 years of observations. We also present an up-to-date period histogram for all known hot subdwarf binaries, which suggests those with F-K main sequence companions tend to have orbital periods on the order of several years. Such long periods challenge the predictions of conventional BPS models, although a larger sample is needed for a thorough assessment of the models' predictive success. Lastly, one of our targets has an eccentric orbit, implying some composite-spectrum systems might have formerly been hierarchical triple systems, in which the inner binary merged to create the hot subdwarf.Comment: Published in The Astrophysical Journal, Volume 758, Issue 1, article id. 58 (2012). References updated and Equation (5) corrected. 12 pages, 5 figures, 5 table

Binding Mechanism of Metal⋅NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases

SummaryPrimases are DNA-dependent RNA polymerases found in all cellular organisms. In bacteria, primer synthesis is carried out by DnaG, an essential enzyme that serves as a key component of DNA replication initiation, progression, and restart. How DnaG associates with nucleotide substrates and how certain naturally prevalent nucleotide analogs impair DnaG function are unknown. We have examined one of the earliest stages in primer synthesis and its control by solving crystal structures of the S. aureus DnaG catalytic core bound to metal ion cofactors and either individual nucleoside triphosphates or the nucleotidyl alarmones, pppGpp and ppGpp. These structures, together with both biochemical analyses and comparative studies of enzymes that use the same catalytic fold as DnaG, pinpoint the predominant nucleotide-binding site of DnaG and explain how the induction of the stringent response in bacteria interferes with primer synthesis

Impact of mid-to-late Holocene precipitation changes on vegetation across lowland tropical South America: a palaeo-data synthesis

A multi-proxy paleo-data synthesis of 110 sites is presented, exploring the impact of mid-to-late Holocene precipitation changes upon vegetation across Southern Hemisphere tropical South America. We show that the most significant vegetation changes occurred in south-west Amazonia and south-east Brazil, regions reliant on precipitation derived from the South American summer monsoon (SASM). A drier mid Holocene in these regions, linked to a weaker SASM, favoured more open vegetation (savannah/grasslands) than present, while increased late-Holocene precipitation drove expansion of humid forests (e.g. evergreen tropical forest in south-west Amazonia, Araucaria forests in south-east Brazil). The tropical forests of central, western and eastern Amazonia remained largely intact throughout this 6000-year period. North-eastern Brazil's climate is 'antiphased' with the rest of tropical South America, but a lack of paleo data limits our understanding of how vegetation responded to a wetter(drier) mid(late) Holocene. From this paleo-data perspective, we conclude that ecotonal forests already close to their climatic thresholds are most vulnerable to predicted future drought, but the forest biome in the core of Amazonia is likely to be more resilient. Of greater concern is widespread deforestation and uncontrolled anthropogenic burning, which will decrease ecosystem resilience, making them more vulnerable than they might be without current anthropogenic pressures

ASL Citizen: A Community-Sourced Dataset for Advancing Isolated Sign Language Recognition

Sign languages are used as a primary language by approximately 70 million D/deaf people world-wide. However, most communication technologies operate in spoken and written languages, creating inequities in access. To help tackle this problem, we release ASL Citizen, the first crowdsourced Isolated Sign Language Recognition (ISLR) dataset, collected with consent and containing 83,399 videos for 2,731 distinct signs filmed by 52 signers in a variety of environments. We propose that this dataset be used for sign language dictionary retrieval for American Sign Language (ASL), where a user demonstrates a sign to their webcam to retrieve matching signs from a dictionary. We show that training supervised machine learning classifiers with our dataset advances the state-of-the-art on metrics relevant for dictionary retrieval, achieving 63% accuracy and a recall-at-10 of 91%, evaluated entirely on videos of users who are not present in the training or validation sets. An accessible PDF of this article is available at the following link: https://aashakadesai.github.io/research/ASLCitizen_arxiv_updated.pd

Adaptive Event Horizon Tracking and Critical Phenomena in Binary Black Hole Coalescence

This work establishes critical phenomena in the topological transition of black hole coalescence. We describe and validate a computational front tracking event horizon solver, developed for generic studies of the black hole coalescence problem. We then apply this to the Kastor - Traschen axisymmetric analytic solution of the extremal Maxwell - Einstein black hole merger with cosmological constant. The surprising result of this computational analysis is a power law scaling of the minimal throat proportional to time. The minimal throat connecting the two holes obeys this power law during a short time immediately at the beginning of merger. We also confirm the behavior analytically. Thus, at least in one axisymmetric situation a critical phenomenon exists. We give arguments for a broader universality class than the restricted requirements of the Kastor - Traschen solution.Comment: 13 pages, 20 figures Corrected labels on figures 17 through 20. Corrected typos in references. Added some comment

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly. Conventional cellular therapies, such as tumor infiltrating lymphocytes (TIL), are becoming more effective and more available. Gene therapy is becoming an important tool in adoptive cell therapy. Lymphocytes are being engineered to express high affinity T cell receptors (TCRs), chimeric antibody-T cell receptors (CARs) and cytokines. T cell subsets with more naïve and stem cell-like characteristics have been shown in pre-clinical models to be more effective than unselected populations and it is now possible to reprogram T cells and to produce T cells with stem cell characteristics. In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies

A Concept of Operations for an Integrated Vehicle Health Assurance System

This document describes a Concept of Operations (ConOps) for an Integrated Vehicle Health Assurance System (IVHAS). This ConOps is associated with the Maintain Vehicle Safety (MVS) between Major Inspections Technical Challenge in the Vehicle Systems Safety Technologies (VSST) Project within NASA s Aviation Safety Program. In particular, this document seeks to describe an integrated system concept for vehicle health assurance that integrates ground-based inspection and repair information with in-flight measurement data for airframe, propulsion, and avionics subsystems. The MVS Technical Challenge intends to maintain vehicle safety between major inspections by developing and demonstrating new integrated health management and failure prevention technologies to assure the integrity of vehicle systems between major inspection intervals and maintain vehicle state awareness during flight. The approach provided by this ConOps is intended to help optimize technology selection and development, as well as allow the initial integration and demonstration of these subsystem technologies over the 5 year span of the VSST program, and serve as a guideline for developing IVHAS technologies under the Aviation Safety Program within the next 5 to 15 years. A long-term vision of IVHAS is provided to describe a basic roadmap for more intelligent and autonomous vehicle systems