A user interactive calibration program for an object tracking system using a triaxial accelerometer

A major method in object tracking systems and other inertial measurement devices resolves around the use of one, two, or three axis accelerometers. A leader in the field such devices is Microstrain Incorporated. They have developed a three axis accelerometer that uses a three axis magnetic sensor array to compute the pitch, roll, and yaw of a compact inertial measurement unit. In researching such devices, it became apparent that data collected using such units is extremely sensitive both to local magnetic fields and human interactions with the devices. It is therefore of great importance to ensure the device or devices are properly calibrated. In the construction of an effective calibration program, it is necessary to measure and zero out even minor discrepancies, as even small misalignments have deleterious effects on device performance

Bone-to-bone and implant-to-bone impingement : a novel graphical representation for hip replacement planning

Bone-to-bone impingement (BTBI) and implant-to-bone impingement (ITBI) risk assessment is generally performed intra-operatively by surgeons, which is entirely subjective and qualitative, and therefore, lead to sub-optimal results and recurrent dislocation in some cases. Therefore, a method was developed for identifying subject-specific BTBI and ITBI, and subsequently, visualising the impingement area on native bone anatomy to highlight where prominent bone should be resected. Activity definitions and subject-specific bone geometries, with planned implants were used as inputs for the method. The ITBI and BTBI boundary and area were automatically identified using ray intersection and region growing algorithm respectively to retain the same ‘conical clearance angle’ obtained to avoid prosthetic impingement (PI). The ITBI and BTBI area was then presented with different colours to highlight the risk of impingement, and importance of resection. A clinical study with five patients after 2 years of THA was performed to validate the method. The results supported the study hypothesis, in that the predicted highest risk area (red coloured zone) was completely/majorly resected during the surgery. Therefore, this method could potentially be used to examine the effect of different pre-operative plans and hip motions on BTBI, ITBI, and PI, and to guide bony resection during THA surgery

Stability of a flexible insert in one wall of an inviscid channel flow

A hybrid of computational and theoretical methods is extended and used to investigate the instabilities of a flexible surface inserted into one wall of an otherwise rigid channel conveying an inviscid flow. The computational aspects of the modelling combine finite-difference and boundary-element methods for structural and fluid elements respectively. The resulting equations are coupled in state-space form to yield an eigenvalue problem for the fluid–structure system. In tandem, the governing equations are solved to yield an analytical solution applicable to inserts of infinite length as an approximation for modes of deformation that are very much shorter than the overall length of the insert. A comprehensive investigation of different types of inserts – elastic plate, damped flexible plate, tensioned membrane and spring-backed flexible plate – is conducted and the effect of the proximity of the upper channel wall on stability characteristics is quantified. Results show that the presence of the upper-channel wall does not significantly modify the solution morphology that characterises the corresponding open-flow configuration, i.e. in the absence of the rigid upper channel wall. However, decreasing the channel height is shown to have a very significant effect on instability-onset flow speeds and flutter frequencies, both of which are reduced. The channel height above which channel-confinement effects are negligible is shown to be of the order of the wavelength of the critical mode at instability onset. For spring-backed flexible plates the wavelength of the critical mode is much shorter than the insert length and we show very good agreement between the predictions of the analytical and the state-space solutions developed in this paper. The small discrepancies that do exist are shown to be caused by an amplitude modulation of the critical mode on an insert of finite length that is unaccounted for in the travelling-wave assumption of the analytical model. Overall, the key contribution of this paper is the quantification of the stability bounds of a fundamental fluid–structure interaction (FSI) system which has hitherto remained largely unexplored

Extension rates across the northern Shanxi Grabens, China, from Quaternary geology, seismicity and geodesy

Discrepancies between geological, seismic and geodetic rates of strain can indicate that rates of crustal deformation, and hence seismic hazard, are varying through time. Previous studies in the northern Shanxi Grabens, at the northeastern corner of the Ordos Plateau in northern China, have found extension rates of anywhere between 0 and 6 mm a−1 at an azimuth of between 95° and 180°. In this paper we determine extension rates across the northern Shanxi Grabens from offset geomorphological features and a variety of Quaternary dating techniques (including new IRSL and Ar-Ar ages), a Kostrov summation using a 700 yr catalogue of historical earthquakes, and recent campaign GPS measurements. We observe good agreement between Quaternary, seismic and geodetic rates of strain, and we find that the northern Shanxi Grabens are extending at around 1–2 mm a−1 at an azimuth of ≈151°. The azimuth of extension is particularly well constrained and can be reliably inferred from catalogues of small earthquakes. We do not find evidence for any substantial variations in extension rate through time, though there is a notable seismic moment rate deficit since 1750. This deficit could indicate complex fault interactions across large regions, aseismic accommodation of deformation, or that we are quite late in the earthquake cycle with the potential for larger earthquakes in the relatively near future

The alpha-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations

Five-membered secondary amine heterocycles containing an α-heteroatom were prepared and shown to be ineffective as catalysts for the iminium ion catalysed Diels–Alder reaction between cinnamaldehyde and cyclopentadiene. Their six-membered counterparts proved to be highly active catalysts. In stark contrast, the catalytic activity observed when comparing the non α-heteroatom cyclic amines proline methyl ester and methyl pipecolinate showed the five-membered ring amine was significantly more active. Concurrent density functional theoretical calculations suggest a rationale for the observed trends in reactivity, highlighting that LUMO activation through an iminium ion intermediate plays a key role in catalytic activity

Pathways Forward for Indigenous Language Reclamation: Engaging Indigenous Epistemology and Learning by Observing and Pitching in to Family and Community Endeavors

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155958/1/modl12652.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155958/2/modl12652_am.pd

Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS)

BACKGROUND Acute liver rejection (ALR), a significant complication of liver transplantation, burdens patients, healthcare payers, and the healthcare providers due to an increase in morbidity, cost, and resources. Despite clinical resolution, ALR is associated with an increased risk of graft loss. A unique protocol of delayed immunosuppression used in our institute provided a model to characterize metabolomic profiles in human ALR. MATERIAL AND METHODS Twenty liver allograft biopsies obtained 48 hours after liver transplantation in the absence of immunosuppression were studied. Hepatic metabolites were quantitated in these biopsies by liquid chromatography and mass spectroscopy (LC/MS). Metabolite profiles were compared among: 1) biopsies with reperfusion injury but no histological evidence of rejection (n=7), 2) biopsies with histological evidence of moderate or severe rejection (n=5), and 3) biopsies with histological evidence of mild rejection (n=8). RESULTS There were 133 metabolites consistently detected by LC/MS and these were prioritized using variable importance to projection (VIP) analysis, comparing moderate or severe rejection vs. no rejection or mild rejection using partial least squares discriminant statistical analysis (PLS-DA). Twenty metabolites were identified as progressively different. Further PLS-DA using these metabolites identified 3 metabolites (linoleic acid, γ-linolenic acid, and citrulline) which are associated with either cyclooxygenase or nitric oxide synthase functionality. CONCLUSIONS Hepatic metabolic aberrancies associated with cyclooxygenase and nitric oxide synthase function occur contemporaneous with ALR. Additional studies are required to better characterize the role of these metabolic pathways to enhance utility of the metabolomics approach in diagnosis and outcomes of ALR

Dark matter constraints on the parameter space and particle spectra in the nonminimal SUSY standard model

We investigate the dark matter constraints for the nonminimal SUSY standard model (NMSSM). The cosmologically restricted mass spectra of the NMSSM are compared to the minimal SUSY standard model (MSSM). The differences of the two models concerning the neutralino, sfermion and Higgs sector are discussed. The dark matter condition leads to cosmologically allowed mass ranges for the SUSY particles in the NMSSM: m_{\tilde{\chi}^0_1} < 300 GeV, m_{\tilde{e}_R} < 300 GeV, 300 GeV < m_{\tilde{u}_R} < 1900 GeV, 200 GeV < m_{\tilde{t}_1} < 1500 GeV, 350 GeV < m_{\tilde{g}} < 2100 GeV and for the mass of the lightest scalar Higgs m_{S_1} < 140 GeV.Comment: revised version to appear in Phys. Lett. B, 18 pages, LaTeX, 3 figures, uses epsfig.sty and amssymb.st

Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway

Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence resonance energy transfer) sensor for cAMP, CAMYEL (cAMP sensor using YFP-Epac-RLuc), which can quantitatively and rapidly monitor intracellular concentrations of cAMP in vivo. This sensor was used to characterize three distinct pathways for modulation of cAMP synthesis stimulated by presumed Gs-dependent receptors for isoproterenol and prostaglandin E2. Whereas two ligands, uridine 5'-diphosphate and complement C5a, appear to use known mechanisms for augmentation of cAMP via Gq/calcium and Gi, the action of sphingosine 1-phosphate (S1P) is novel. In these cells, S1P, a biologically active lysophospholipid, greatly enhances increases in intracellular cAMP triggered by the ligands for Gs-coupled receptors while having only a minimal effect by itself. The enhancement of cAMP by S1P is resistant to pertussis toxin and independent of intracellular calcium. Studies with RNAi and chemical perturbations demonstrate that the effect of S1P is mediated by the S1P2 receptor and the heterotrimeric G13 protein. Thus in these macrophage cells, all four major classes of G proteins can regulate intracellular cAMP

Paying the pipers: mitigating the impact of anticoagulant rodenticides on predators and scavengers

Anticoagulant rodenticides, mainly second-generation forms, or SGARs, dominate the global market for rodent control. Introduced in the 1970s to counter genetic resistance in rodent populations to first-generation compounds such as warfarin, SGARs are extremely toxic and highly effective killers. However, their tendency to persist and accumulate in the body has led to the widespread contamination of terrestrial predators and scavengers. Commercial chemicals that are classified by regulators as persistent, bio-accumulative, and toxic (PBT) chemicals and that are widely used with potential environmental release, such as dichloro-diphenyl-trichloroethane (DDT) or polychlorinated biphenyls (PCBs), have been removed from commerce. However, despite consistently failing ecological risk assessments, SGARs remain in use because of the demand for effective rodent-control options and the lack of safe and humane alternatives. Although new risk-mitigation measures for rodenticides are now in effect in some countries, the contamination and poisoning of nontarget wildlife are expected to continue. Here, we suggest options to further attenuate this problem