Elastography in HCV patients

Summary Introduction:  Liver fibrosis (LB) assessment plays an important role in hepatology. A common characteristic of all chronic liver diseases is the occurrence and progression of fibrosis towards cirrhosis. Besides its plain interest for prognosis purposes, determining the fibrosis reveals the natural history of the disease and the risk factors associated with its progression to guide the antifibrotic action of different treatments. Discussion:  Today, in clinical practice there are three available methods for the evaluation of LB. Biopsy, which is still considered as the 'gold standard' method. Serological markers and their mathematical combination are suggested in the last years in alternative to LB. More recently, transient elastography (TE) was proposed. TE is a simple and noninvasive method for measuring liver stiffness. This technique is based on the progression speed of an elastic shear wave within the liver. Conclusions:  Currently, there are just a few studies capable of evaluating the TE effectiveness in chronic liver diseases, mainly in patients infected with hepatitis C virus (HCV). Its application must also be studied in the monitoring of patients suffering from chronic HCV infection and subjected to a treatment that can modify their degree of liver fibrosis. The results of TE must be interpreted according to the clinical background of the specialist

Treating Smalt: A Preliminary SEM-EDX Study of the Effects of Aqueous-based Alkaline Conservation Treatments on Smalt in Wall Paintings

Smalt is a blue cobalt-coloured glass pigment used in European wall paintings from the early Renaissance period that became a popular choice for artists due to its unique tone, availability, and ve..

A protocol for global multiphase estimation

Global estimation strategies allow to extract information on a phase or a set of phases without any prior knowledge, which is, instead, required for local estimation strategies. We devise a global multiphase protocol based on Holevo's estimation theory and apply it to the case of digital estimation, i.e. we estimate the phases in terms of the mutual information between them and the corresponding estimators. In the single-phase scenario, the protocol encompasses two specific known optimal strategies. We extend them to the simultaneous estimation of two phases and evaluate their performance. Then, we retrieve the ultimate digital bound on precision when a generic number of phases is simultaneously estimated. We show that in the multiphase strategy there is only a constant quantum advantage with respect to a sequence of independent single-phase estimations. This extends a recent similar result, which settled a controversy on the search for the multiphase enhancement

Nine ideas to improve the clinical management of HIV infected patients during the COVID-19 pandemic

Globally, in 2019, HIV infection was still responsible for 1.7 million new infections 2.2 and for 690,000 deaths in the same year. Tailored and new antiretroviral therapy (ART) regimens, individualised follow-up and new technologies to support data-sharing between health—care professional caring for people living with HIV (PLHIV) and to deliver ART to patients are desperately needed to reach the 90-90-90-90 ambitious goals. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, responsible for the Coronavirus-19 (COVID-19) pandemic that spread globally in 2020, posed a huge challenge for PLHIV and HIV physicians worldwide in terms of continuum of care.In this paper we encourage “up-to-date patient-centred HIV medicine” and we give nine ideas to improve HIV management in clinical practice during the COVID-19 pandemic

Egidio Feruglio : Estratígrafo de la Patagonia

A los 25 años de la desaparición del Dr. Egidio Feruglio, la Asociación Geológica Argentina desea recordar, a través de esla nota preparada por el Dr. Giovanni Cecioni, la obra y personalidad del destacado investigador de la Patagonia.Facultad de Ciencias Naturales y Muse

Egidio Feruglio : Estratígrafo de la Patagonia

A los 25 años de la desaparición del Dr. Egidio Feruglio, la Asociación Geológica Argentina desea recordar, a través de esla nota preparada por el Dr. Giovanni Cecioni, la obra y personalidad del destacado investigador de la Patagonia.Facultad de Ciencias Naturales y Muse

Metacognition as a predictor of improvements in personality disorders

Personality Disorders (PDs) are particularly hard to treat and treatment drop-out rates are high. Several authors have agreed that psychotherapy is more successful when it focuses on the core of personality pathology. For this reason, therapists dealing with PDs need to understand the psychopathological variables that characterize this pathology and exactly what contributes to maintaining psychopathological processes. Moreover, several authors have noted that one key problem that characterizes all PDs is an impairment in understanding mental states - here termed metacognition - which could also be responsible for therapy failures. Unfortunately, a limited number of studies have investigated the role of mentalization in the process of change during psychotherapy. In this paper, we assume that poor metacognition corresponds to a core element of the general pathology of personality, impacts a series of clinical variables, generates symptoms and interpersonal problems, and causes treatment to be slower and less effective. We explored whether changes in metacognition predicted an improvement among different psychopathological variables characterizing PDs; 193 outpatients were treated at the Third Center of Cognitive Psychotherapy in Rome, Italy, and followed a structured path tailored for the different psychopathological variables that emerged from a comprehensive psychodiagnostic assessment that considered patients' symptoms, metacognitive abilities, interpersonal relationships, personality psychopathology, and global functioning. The measurements were repeated after a year of treatment. The results showed that changes in metacognitive abilities predicted improvements in the analyzed variable

Which benefit from subsequent chemotherapy lines beyond the second for women with metastatic breast cancer? Evidence from a single-center retrospective analysis of survivorship

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