844 research outputs found

    Componente psicopedagógico para el modelo educativo de los colegios de las Misioneras del Sagrado Corazón de Jesús y Santa María de Guadalupe

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    “La educación es un elemento crucial para alcanzar un mundo próspero, sostenible y equitativo; el no mirarle, pone en peligro los principios democráticos y de justicia, ya que la educación juega un papel primordial en la erradicación de la pobreza y encausa la visión de un país hacia el crecimiento y desarrollo sostenible. La 70a Asamblea General de las Naciones Unidas en 2015, determinó una agenda universal para 2030 conocida como Objetivos Mundiales de Desarrollo Sostenible con los que se pretende garantizar una educación inclusiva, equitativa y de calidad que promueva oportunidades de aprendizaje durante toda la vida para todos. La Organización para la Cooperación y Desarrollo Económicos (OCDE) ha logrado avances en materia educativa según el documento “Panorama de la Educación 2017”, sin embargo; aún existen varios desafíos importantes respecto a los resultados de aprendizaje y de equidad. Los intentos por lograr los retos que el mundo global demanda a nuestro país, han generado una serie de transformaciones al modelo educativo nacional, mismos que impactan de manera directa en el trabajo diario de las instituciones educativas y sus maestros frente a grupo”

    Immunochemical study of a transforming growth factor-α-related protein in the chicken kidney

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    Immunochemical study of a transforming growth factor-α-related protein in the chicken kidney. A number of polypeptides are involved in renal growth and physiology. Both transforming growth factor-α (TGF-α) protein and mRNA are expressed in kidney cells during embryonic and adult stages, and exert mitogenic activity on kidney cells in culture. We studied the immunolocalization of a TGF-α-related protein at the ultrastructural level and found it in the basolateral membranes of dark cells from distal tubules of the chicken kidney. By Western blotting techniques, we identified a protein complex composed of at least two TGF-α immunoreactive subunits of 40 and 88 kDa, respectively. Both subunits were sensitive to elastase digestion, and released TGF-α immunoreactive products. In addition, TGF-α immunoreaction was found in primary culture of chicken kidney cells. These findings suggest that the TGF-α-related protein complex plays a very specific role in proliferation and/or differentiation of kidney cells

    Analyzing the differences between reads and contigs when performing a taxonomic assignment comparison in metagenomics

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    Metagenomics is an inherently complex field in which one of the primary goals is to determine the compositional organisms present in an environmental sample. Thereby, diverse tools have been developed that are based on the similarity search results obtained from comparing a set of sequences against a database. However, to achieve this goal there still are affairs to solve such as dealing with genomic variants and detecting repeated sequences that could belong to different species in a mixture of uneven and unknown representation of organisms in a sample. Hence, the question of whether analyzing a sample with reads provides further understanding of the metagenome than with contigs arises. The assembly yields larger genomic fragments but bears the risk of producing chimeric contigs. On the other hand, reads are shorter and therefore their statistical significance is harder to asses, but there is a larger number of them. Consequently, we have developed a workflow to assess and compare the quality of each of these alternatives. Synthetic read datasets beloging to previously identified organisms are generated in order to validate the results. Afterwards, we assemble these into a set of contigs and perform a taxonomic analysis on both datasets. The tools we have developed demonstrate that analyzing with reads provide a more trustworthy representation of the species in a sample than contigs especially in cases that present a high genomic variability.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    Workflows and service discovery: a mobile device approach

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    Bioinformatics has moved from command-line standalone programs to web-service based environments. Such trend has resulted in an enormous amount of online resources which can be hard to find and identify, let alone execute and exploit. Furthermore, these resources are aimed -in general- to solve specific tasks. Usually, this tasks need to be combined in order to achieve the desired results. In this line, finding the appropriate set of tools to build up a workflow to solve a problem with the services available in a repository is itself a complex exercise. Issues such as services discovering, composition and representation appear. On the technological side, mobile devices have experienced an incredible growth in the number of users and technical capabilities. Starting from this reality, in the present paper, we propose a solution for service discovering and workflow generation while distinct approaches of representing workflows in a mobile environment are reviewed and discussed. As a proof of concept, a specific use case has been developed: we have embedded an expanded version of our Magallanes search engine into mORCA, our mobile client for bioinformatics. Such composition delivers a powerful and ubiquitous solution that provides the user with a handy tool for not only generate and represent workflows, but also services, data types, operations and service types discoveryUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    A generalized smith predictor for unstable time-delay SISO systems

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    [EN] In this work, a generalization of the Smith Predictor (SP) is proposed to control linear time-invariant (LTI) time-delay single-input single-output (SISO) systems. Similarly to the SP, the combination of any stabilizing output-feedback controller for the delay-free system with the proposed predictor leads to a stabilizing controller for the delayed system. Furthermore, the tracking performance and the steady-state disturbance rejection capabilities of the equivalent delay-free loop are preserved. In order to place this contribution in context, some modifications of the SP are revisited and recast under the same structure. The features of the proposed scheme are illustrated through simulations, showing a comparison with respect to the corresponding delay-free loop, which is here considered to be the ideal scenario. In order to emphasize the feasibility of this approach, a successful experimental implementation in a laboratory platform is also reported.This work was partially supported by the projects PROMETEOII/2013/004, Conselleria d'Educacio, Generalitat Valenciana; TIN2014-56158-C4-4-P-AR, Ministerio de Economia y Competitividad; and the FPI-UPV 2014 PhD Grant, Universitat Politecnica de Valencia, Spain.Sanz Díaz, R.; García Gil, PJ.; Albertos Pérez, P. (2017). A generalized smith predictor for unstable time-delay SISO systems. ISA Transactions. 72:197-204. https://doi.org/10.1016/j.isatra.2017.09.020S1972047

    Seguimiento y evaluación de graduados en Sociología y Ciencias Políticas. Comparación de competencias obtenidas en estudios de grado y competencias necesarias

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    El proyecto pretendía la búsqueda de mejoras y nuevas líneas de desarrollo de contenidos y competencias en las asignaturas de los grados de Ciencias Políticas y Sociología, en la UCM y, eventualmente, en otras universidades. El aporte de esta investigación es recabar datos de la realidad a la que se enfrentan los graduados una vez egresados de la universidad. A partir de la obtención de datos empíricos obtenidos de los procesos de empleabilidad y adaptación al mercado que han vivido jóvenes egresados, en sus experiencias de prácticas y primeros empleos, y de la información acumulada que poseen los tutores de prácticas en empresas u organizaciones privadas. Esta información se obtiene a partir de dos encuestas on-line que se desarrollaron tomando en cuenta las experiencias en la mediación y observación de las competencias y desempeños profesionales. Estas encuestas se enviaron a sendas bases de datos de jóvenes egresado y de empleadores/tutores proporcionadas por el Colegio de Politólogos y Sociólogos de Madrid

    Enhanced extended state observer-based control for systems with mismatched uncertainties and disturbances

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    [EN] This paper presents an enhanced Extended State Observer (ESO)-based control strategy to deal with the disturbance attenuation problem for a class of non integral-chain systems subject to non-linear mismatched uncertainties and external disturbances. The proposed control strategy does not assume the integral-chain form and it is formed by a state-feedback plus a dynamic disturbance compensation term, which is designed to reject the disturbance effect in the system output. From a theoretical point of view, the proposed strategy is reduced to the conventional ESO when the integral chain form and the matched condition hold. In this sense, this paper is presented as an extension of the ESO principles to cover a wider class of systems. The theoretical results show that the internal zero-dynamics plays an important role in ESO-based control design. Also, the closed-loop stability is analyzed and some numerical simulations show the effectiveness of the proposal in comparison with previous ESO-based techniques.This work was partially supported by projects FPU15/02008, FPI-UPV 2014 and TIN2014-56158-C4-4-P-AR, Ministerio de Economia y Competitividad, Spain.Castillo-Frasquet, A.; García Gil, PJ.; Sanz Díaz, R.; Albertos Pérez, P. (2017). Enhanced extended state observer-based control for systems with mismatched uncertainties and disturbances. ISA Transactions. 73:1-10. https://doi.org/10.1016/j.isatra.2017.12.005S1107

    Multilevel Zero-One Inflated Beta Regression Model for the Analysis of the Relationship between Exogenous Health Variables and Technical Efficiency in the Spanish National Health System Hospitals

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    Background: This article proposes a methodological innovation in health economics for the second stage analysis of technical efficiency in hospitals. It investigates the relationship between the installed capacity in regions and hospitals and their ownership structure. Methods: A multilevel zero-one inflated beta regression model is employed to model pure technical efficiency more adequately than other models frequently used in econometrics. Results: Compared to publicly managed hospitals, the mean efficiency index of hospitals with public-private partnership (PPP) formulas was 4.27-fold. This figure was 1.90-fold for private hospitals. Concerning the efficiency frontier, the odds ratio (OR) of PPP models vs. public hospitals was 42.06. The OR of private hospitals vs. public hospitals was 8.17. A one standard deviation increase in the percentage of beds in intensive care units increases the odds of being situated on the efficiency frontier by 50%. Conclusions: The proportion of hospital beds in intensive care units relates to a higher chance of being on the efficiency frontier. Hospital ownership structure is related to the mean efficiency index of Spanish National Health Service hospitals, as well as the odds of being situated on the efficiency frontier.EUROPEAN REGIONAL DEVELOPMENT FUND (Operative Program: Andalusia 2014–2020. Ministry of Economy. Knowledge. Business and University. Junta de Andalucía. Spain. Grant number: B-SEJ-266-UGR18

    An Exploration of Wisdom of Crowds using Neutrosophic Cognitive Maps

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    t. The wisdom of crowds (WOC) is a theory where it is believed that a multitude of people, unknown to each other and not experts in some subject, can reach more accurate conclusions on this subject than each of them would achieve individually; it could even have more accuracy than the result that a group of experts would obtain. This theory can be used to obtain information from the individual knowledge of an inexperienced crowd, including knowledge on complex phenomena. In this paper, the complex phenomenon is represented with the help of Neutrosophic Cognitive Maps (NCM), which allow us to capture the cause-effect relations among the concepts according to each of the individuals’ judgments. In this case, a dynamic processing of the results is carried out. The NCMs are aggregated following the WOC principles using an aggregation algorithm, which is based on the Fuzzy Negative-Positive-Neutral (NPN) logic. The advantage of using NCM is that indeterminacy is included in the modeling, thus individuals can express their opinions more reliably
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