Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines

AR056280 awarded to DAB and AL. AIHC supported by IMS and Elphinstone Scholarship from the University of Aberdeen. GRV supported by Medical Research Scotland (Vac-929-2016).Peer reviewedPublisher PD

FootApp: An AI-powered system for football match annotation

In the last years, scientific and industrial research has experienced a growing interest in acquiring large annotated data sets to train artificial intelligence algorithms for tackling problems in different domains. In this context, we have observed that even the market for football data has substantially grown. The analysis of football matches relies on the annotation of both individual players’ and team actions, as well as the athletic performance of players. Consequently, annotating football events at a fine-grained level is a very expensive and error-prone task. Most existing semi-automatic tools for football match annotation rely on cameras and computer vision. However, those tools fall short in capturing team dynamics and in extracting data of players who are not visible in the camera frame. To address these issues, in this manuscript we present FootApp, an AI-based system for football match annotation. First, our system relies on an advanced and mixed user interface that exploits both vocal and touch interaction. Second, the motor performance of players is captured and processed by applying machine learning algorithms to data collected from inertial sensors worn by players. Artificial intelligence techniques are then used to check the consistency of generated labels, including those regarding the physical activity of players, to automatically recognize annotation errors. Notably, we implemented a full prototype of the proposed system, performing experiments to show its effectiveness in a real-world adoption scenario

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment

Pessimistic Rescaling and Distribution Shift of Boosting Models for Impression-Aware Online Advertising Recommendation

In this paper, we provide an overview of the approach we used as team Gabibboost for the ACM RecSys Challenge 2023, organized by ShareChat and Moj. The challenge focused on predicting user activity in the online advertising setting based on impression data, in particular, predicting whether a user would install an advertised application using a high-dimensional anonymized feature vector. Our proposed solution is based on an ensemble model that combines the strengths of several machine learning sub-models, including CatBoost, LightGBM, HistGradientBoosting, and two hybrid models. Our proposal is able to harness the strengths of our models through a distribution shift postprocessing and fine-Tune the final prediction via a custom build pessimistic rescaling function. The final ensemble model allowed us to rank 1st on the academic leaderboard and 9th overall

Aluminum alloy production for the reinforcement of the CMS conductor

The Compact Muon Solenoid (CMS) is one of the general-purpose detectors to be provided for the Large Hadron Collider (LHC) project at CERN. The design field of the CMS superconducting magnet is 4 T, the magnetic length is 12.5 m and the free bore is 6 m. To reinforce the high-purity (99.998%) Al-stabilized conductor of the magnet against the magnetic loadings experienced during operation at 4.2 K, two continuous sections of Al-alloy (AA) reinforcement are Electron Beam (EB) welded to it. The reinforcements have a section of 24*18 mm and are produced in continuous 2.55 km lengths. The alloy EN AW-6082 has been selected for the reinforcement due to its excellent extrudability, high strength in the precipitation hardened states, high toughness and strength at cryogenic temperature and good EB weldability. Each of the continuous lengths of the reinforcement is extruded billet on billet and press quenched on-line from the extrusion temperature in an industrial extrusion plant. In order to insure the ready EB weldability of the reinforcement onto the pure aluminum of the insert, tight dimensional tolerances and proper surface finish of the reinforcement are required in the as-extruded state. As well, in order to facilitate the winding operation of the conductor, the uniformity of the mechanical properties of the extruded reinforcement, especially at the billet on billet joints, is critical. To achieve these requirements in an industrial environment, substantial effort was made to refine existing production techniques and to monitor critical extrusion parameters during production. This paper summarizes the main results obtained during the establishment of the extrusion line and of the production phase of the reinforcement. (10 refs)

Triptycene-Roofed Quinoxaline Cavitands for the Supramolecular Detection of BTEX in Air

Two novel triptycene quinoxaline cavitands (DiTriptyQxCav and MonoTriptyQxCav) have been designed, synthesized, and applied in the supramolecular detection of benzene, toluene, ethylbenzene, and xylenes (BTEX) in air. The complexation properties of the two cavitands towards aromatics in the solid state are strengthened by the presence of the triptycene moieties at the upper rim of the tetraquinoxaline walls, promoting the confinement of the aromatic hydrocarbons within the cavity. The two cavitands were used as fiber coatings for solid-phase microextraction (SPME) BTEX monitoring in air. The best performances in terms of enrichment factors, selectivity, and LOD (limit of detection) values were obtained by using the DiTriptyQxCav coating. The corresponding SPME fiber was successfully tested under real urban monitoring conditions, outperforming the commercial divinylbenzene\u2013Carboxen\u2013polydimethylsiloxane (DVB\u2013CAR\u2013PDMS) fiber in BTEX adsorption

DREB/CBF expression in wheat and barley using the stress-inducible promoters of HD-Zip I genes: impact on plant development, stress tolerance and yield

Networks of transcription factors regulate diverse physiological processes in plants to ensure that plants respond to abiotic stresses rapidly and efficiently. In this study, expression of two DREB/CBF genes, TaDREB3 and TaCBF5L, was modulated in transgenic wheat and barley, by using stress‐responsive promoters HDZI‐3 and HDZI‐4. The promoters were derived from the durum wheat genes encoding the γ‐clade TFs of the HD‐Zip class I subfamily. The activities of tested promoters were induced by drought and cold in leaves of both transgenic species. Differences in sensitivity of promoters to drought strength were dependent on drought tolerance levels of cultivars used for generation of transgenic lines. Expression of the DREB/CBF genes under both promoters improved drought and frost tolerance of transgenic barley, and frost tolerance of transgenic wheat seedlings. Expression levels of the putative TaCBF5L downstream genes in leaves of transgenic wheat seedlings were up‐regulated under severe drought, and up‐ or down‐regulated under frost, compared to those of control seedlings. The application of TaCBF5L driven by the HDZI‐4 promoter led to the significant increase of the grain yield of transgenic wheat, compared to that of the control wild‐type plants, when severe drought was applied during flowering; although no yield improvements were observed when plants grew under well‐watered conditions or moderate drought. Our findings suggest that the studied HDZI promoters combined with the DREB/CBF factors could be used in transgenic cereal plants for improvement of abiotic stress tolerance, and the reduction of negative influence of transgenes on plant development and grain yields

Early progression of the autonomic dysfunction observed in pediatric type 1 diabetes mellitus

To focus on early cardiac and vascular autonomic dysfunction that might complicate type 1 diabetes mellitus in children, we planned an observational, cross-sectional study in a population of 93 young patients, under insulin treatment, subdivided in 2 age subgroups (children: 11.5 +/- 0.4 years; adolescents: 19.3 +/- 0.2 years). Time and frequency domain analysis of RR interval and systolic arterial pressure variability provided quantitative indices of the sympatho-vagal balance regulating the heart period, of the gain of cardiac baroreflex, and of the sympathetic vasomotor control. Sixty-eight children of comparable age served as a reference group. At rest, systolic arterial pressure and the power of its low-frequency component were greater in patients than in controls, particularly in children (14.0 +/- 2.3 versus 3.1 +/- 0.3 mm Hg(2)). Moreover, baroreflex gain was significantly reduced in both subgroups of patients. Standing induced similar changes in the autonomic profiles of controls and patients. A repeat study after 1 year showed a progression in low- frequency oscillations of arterial pressure and a shift toward low frequency in RR variability. Data in young patients with type 1 diabetes mellitus show a significant increase in arterial pressure, a reduced gain of the baroreflex regulation of the heart period, and an increase of the low- frequency component of systolic arterial pressure variability, suggestive of simultaneous impairment of vagal cardiac control and increases of sympathetic vasomotor regulation. A repeat study after 1 year shows a further increase of sympathetic cardiac and vascular modulation, suggesting early progression of the autonomic dysfunction

Continuous EB welding of the reinforcement of the CMS conductor

The Compact Muon Solenoid (CMS) is one of the general-purpose detectors to be provided for the LHC project at CERN. The design field of the CMS superconducting magnet is 4 T, the magnetic length is 12.5 m and the free bore is 6 m. In order to withstand the electro-mechanical forces during the operation of the CMS magnet, the superconducting cable embedded in a 99.998% pure aluminum matrix is reinforced with two sections of aluminum alloy EN AW-6082 assembled by continuous Electron Beam Welding (EBW). A dedicated production line has been designed by Techmeta, a leading company in the field of EBW. The production line has a total length of 70 m. Non-stop welding of each of the 20 lengths of 2.5 km, required to build the coil, will last 22 hours. EBW is the most critical process involved in the production line. The main advantage of the EBW process is to minimize the Heat Affected Zone; this is particularly important for avoiding damage to the superconducting cable located only 4.7 mm from the welded joints. Two welding guns of 20 kW each operate in parallel in a vacuum chamber fitted with dynamic airlocks. After welding, the conductor is continuously machined on the four faces and on each corner to obtain the required dimensions and surface finish. Special emphasis has been put on quality monitoring. All significant production parameters are recorded during operation and relevant samples are taken from each produced length for destructive testing purposes. In addition, a continuous phased array ultrasonic checking device is located immediately after the welding unit for the continuous welding quality control, along with a dimension laser measurement unit following the machining. (8 refs)

Molecular Basis of the ABA Dependent Modulation of CONSTANS Activity in Drought Escape Response

Plants ability to adapt their development in response to environmental changes is one key factor underlying their evolutionary success. Phytohormones modulate different plant\u2013environment interactions, namely the regulation of flowering time that is crucial to synchronize the onset of the reproductive phase with the most favorable conditions. In Arabidopsis thaliana the plant hormone abscisic acid (ABA), known to regulate various drought stress responses, promotes flowering under long day but not short day conditions. Genetic analyses support a model where ABA signals interact with the photoperiodic pathway, upstream of the flowering gene FLOWERING LOCUS T. Aims of my project are to define how ABA and photoperiod signaling interact. My genetic data indicates that ABA promotes flowering by modulating the activity of the FT activator CONSTANS (CO) rather than its transcriptional regulation. Initial data about the molecular basis of this ABA\u2013CO interaction will be presented. Our study point to CO as the key integrator between ABA signals and the photoperiodic pathway, allowing plants to coordinate flowering time according to the prevailing watering conditions