607 research outputs found
Self-consistent Coulomb effects and charge distribution of quantum dot arrays
This paper considers the self-consistent Coulomb interaction within arrays of
self-assembled InAs quantum dots (QDs) which are embedded in a pn structure.
Strong emphasis is being put on the statistical occupation of the electronic QD
states which has to be solved self-consistently with the actual
three-dimensional potential distribution. A model which is based on a Green's
function formalism including screening effects is used to calculate the
interaction of QD carriers within an array of QDs, where screening due to the
inhomogeneous bulk charge distribution is taken into acount. We apply our model
to simulate capacitance-voltage (CV) characteristics of a pn structure with
embedded QDs. Different size distributions of QDs and ensembles of spatially
perodic and randomly distributed arrays of QDs are investigated.Comment: submitted to pr
The molecular basis, genetic control and pleiotropic effects of local gene co-expression.
Nearby genes are often expressed as a group. Yet, the prevalence, molecular mechanisms and genetic control of local gene co-expression are far from being understood. Here, by leveraging gene expression measurements across 49 human tissues and hundreds of individuals, we find that local gene co-expression occurs in 13% to 53% of genes per tissue. By integrating various molecular assays (e.g. ChIP-seq and Hi-C), we estimate the ability of several mechanisms, such as enhancer-gene interactions, in distinguishing gene pairs that are co-expressed from those that are not. Notably, we identify 32,636 expression quantitative trait loci (eQTLs) which associate with co-expressed gene pairs and often overlap enhancer regions. Due to affecting several genes, these eQTLs are more often associated with multiple human traits than other eQTLs. Our study paves the way to comprehend trait pleiotropy and functional interpretation of QTL and GWAS findings. All local gene co-expression identified here is available through a public database ( https://glcoex.unil.ch/ )
Superconductivity in MgB_2 doped with Ti and C
Measurements of the superconducting upper critical field, H_{c2}, and
critical current density, J_c, have been carried out for MgB_2 doped with Ti
and/or C in order to explore the problems encountered if these dopants are used
to enhance the superconducting performance. Carbon replaces boron in the MgB_2
lattice and apparently shortens the electronic mean free path thereby raising
H_c2. Titanium forms precipitates of either TiB or TiB_2 that enhance the flux
pinning and raise J_c. Most of these precipitates are intra-granular in the
MgB_2 phase. If approximately 0.5% Ti and approximately 2% C are co-deposited
with B to form doped boron fibers and these fibers are in turn reacted in Mg
vapor to form MgB_2, the resulting superconductor has H_{c2}(T=0) ~ 25 T and
J_c ~ 10,000 A/cm**2 at 5 K and 2.2 T.Comment: 11 pages, 10 figure
Possible Z2 phase and spin-charge separation in electron doped cuprate superconductors
The SU(2) slave-boson mean-field theory for the tt'J model is analyzed. The
role of next-nearest-neighbor hopping t' on the phase-diagram is studied. We
find a pseudogap phase in hole-doped materials (where t'<0). The pseudo-gap
phase is a U(1) spin liquid (the staggered-flux phase) with a U(1) gauge
interaction and no fractionalization. This agrees with experiments on hole
doped samples. The same calculation also indicates that a positive t' favors a
Z2 state with true spin-charge separation. The Z2 state that exists when t' >
0.5J can be a candidate for the pseudo-gap phase of electron-doped cuprates (if
such a phase exists). The experimental situation in electron-doped materials is
also addressed.Comment: 6 pages, 2 figures, RevTeX4. Homepage http://dao.mit.edu/~wen
Noncommutative massive Thirring model in three-dimensional spacetime
We evaluate the noncommutative Chern-Simons action induced by fermions
interacting with an Abelian gauge field in a noncommutative massive Thirring
model in (2+1)-dimensional spacetime. This calculation is performed in the
Dirac and Majorana representations. We observe that in Majorana representation
when goes to zero we do not have induced Chern-Simons term in the
dimensional regularization scheme.Comment: Accepted to Phys. Rev. D; 9 pages, Revtex4, no figures, references
added, minor improvements, Eq.31 correcte
Ab initio study of the beta$-tin->Imma->sh phase transitions in silicon and germanium
We have investigated the structural sequence of the high-pressure phases of
silicon and germanium. We have focussed on the cd->beta-tin->Imma->sh phase
transitions. We have used the plane-wave pseudopotential approach to the
density-functional theory implemented within the Vienna ab-initio simulation
package (VASP). We have determined the equilibrium properties of each structure
and the values of the critical parameters including a hysteresis effect at the
phase transitions. The order of the phase transitions has been obtained
alternatively from the pressure dependence of the enthalpy and of the internal
structure parameters. The commonly used tangent construction is shown to be
very unreliable. Our calculations identify a first-order phase transition from
the cd to the beta-tin and from the Imma to the sh phase, and they indicate the
possibility of a second-order phase-transition from the beta-tin to the Imma
phase. Finally, we have derived the enthalpy barriers between the phases.Comment: 12 pages, 16 figure
Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration
YesPolysialic acid (polySia), an α-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated posttranslational
modification predominantly found on NCAM (neuronal cell adhesion molecule). Whilst high levels are expressed during development, peripheral adult organs do not express polySia-NCAM. However, tumours of neural crest-origin re-express polySia-NCAM: its occurrence correlates with aggressive and invasive disease and poor clinical prognosis in different cancer types, notably including small cell lung cancer (SCLC), pancreatic cancer and neuroblastoma. In neuronal development, polySia-NCAM biosynthesis is catalysed by two polysialyltransferases, ST8SiaII and ST8SiaIV, but it is ST8SiaII that is the prominent enzyme in tumours. The aim of this study was to determine the effect of ST8SiaII inhibition by a small molecule on tumour cell migration, utilising cytidine monophosphate (CMP) as a tool compound. Using immunoblotting we showed that CMP reduced ST8iaII-mediated polysialylation of NCAM. Utilizing a novel HPLC-based assay to quantify polysialylation of a fluorescent acceptor (DMB-DP3), we demonstrated that CMP is a competitive inhibitor of ST8SiaII (Ki = 10 μM). Importantly, we have shown that CMP causes a concentration-dependent reduction in tumour cell-surface polySia expression, with an absence of toxicity. When ST8SiaII-expressing tumour cells (SH-SY5Y and C6-STX) were evaluated in 2D cell migration assays, ST8SiaII inhibition led to significant reductions in migration, while CMP had no effect on cells not expressing ST8SiaII (DLD-1 and C6-WT). The study demonstrates for the first time that a polysialyltransferase inhibitor can modulate migration in ST8SiaII-expressing tumour cells. We conclude that ST8SiaII can be considered a druggable target with the potential for interfering with a critical mechanism in tumour cell dissemination in metastatic cancers.Yorkshire Cancer Research; EPSRC; Association for International Cancer Research; Jordanian Government PhD scholarshi
Dinâmica computacional de fluidos: análise do coeficiente de arrasto durante o deslize subaquático
O objectivo deste estudo foi analisar o efeito da profundidade no arrasto
hidrodinâmico durante o deslize subaquático, utilizando a dinâmica computacional de fluidos
Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations
Item does not contain fulltextBACKGROUND: Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular diseases (CVD). HHCY may interact with hypertension (HTEN) and an unfavorable cholesterol profile (UNFAVCHOL) to alter the risk of CVD. OBJECTIVES: To estimate the prevalences of HHCY (1) isolated and (2) in combination with UNFAVCHOL and/or HTEN in different age categories. To provide information that may improve the screening and treatment of subjects at risk of CVD. DESIGN: Cross-sectional data on 12,541 men and 12,948 women aged 20 + y were used from nine European studies. RESULTS: The prevalence of isolated HHCY was 8.5% in subjects aged 20-40 y, 4.7% in subjects aged 40-60 y and 5.9% in subjects aged over 60 y. When combining all age groups, 5.3% had isolated HHCY and an additional 5.6% had HHCY in combination with HTEN and/or UNFAVCHOL. The combinations of risk factors increased with age and, except for HHCY&UNFAVCHOL, were more prevalent than predicted by chance. Of the young subjects (20-40 y), 24% suffered from one or more of the investigated CVD risk factors. This figure was 75.1% in the old subjects (60+ years). CONCLUSIONS: A substantial number of subjects in selected European populations have HHCY (10.9%). In half of these cases, subjects suffer also from other CVD risk factors like UNFAVCHOL and HTEN. Older people in particular tend to have more than one risk factor. Healthcare professionals should be aware of this when screening and treating older people not only for the conventional CVD risk factors like UNFAVCHOL and HTEN but also HHCY, as this can easily be reduced through increased intake of folic acid via supplement or foods fortified with folic acid
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