The Crisscrossing of Time in Spenser’s Amoretti LXXV and Shakespeare’s Sonnet XVIII

Time is a prevalent motif in Elizabethan love sonnets, presenting itself not only as natural force to be reckoned, but also as an oppositional element in humanity’s constant search for immortality. Through the analysis of both Edmund Spenser’s Amoretti LXXV and William Shakespeare’s Sonnet XVIII I intend to explore, compare and contrast the representations of Time in their verses as well as the poets’ promises of immortality through their own writings. Drawing from Horace’s Odes and Ovid’s Metamorphoses as referential works in the discussion of Time in poetry, I will highlight how the struggle to survive the natural passage of time and its corrosive effects while having art as medium may have inspired both Spenser and Shakespeare’s efforts into building their own metonymical pieces of art. Through this work I hope to delve further into the motif of Time as a force that opposes the logic of stability and immutability often proposed by an art that promises the immortalization of one’s love interest

Metabolic Diseases: a differential diagnosis of primary progressive multiple sclerosis

Objectives: The overall aim of our research project is to develop a Next Generation Sequencing strategy to identify metabolic disorders in 104 patients with a presumptive diagnosis of primary progressive MS.We would like to thank to MERCK, SA and NORTE2020 (NORTE-01-0246-FEDER-000014) for funding this Project.N/

Weaning of Senegalese sole (Solea senegalensis) postlarvae to an inert diet with a co-feeding regime

The objective of this study was to evaluate the weaning success of Senegalese sole, Solea senegalensis, postlarvae when co-fed a compound diet, by means of the analysis of growth parameters (relative growth rate [RGR] and condition factor [K]), survival, protein and lipid content. Total ammonia in the rearing water was also measured. The experiment lasted for 46 days (36 to 82 days posthatching). One group was fed only with enriched Artemia sp. metanauplii (Artemia treatment), whereas in another group, the Artemia sp. metanauplii were gradually replaced by the International Council for the Exploration of the Sea (ICES) diet over a period of 39 days (ICES treatment). Postlarvae were sampled on rearing days 0, 9, 23, 30, 39 and 46 for growth and biochemical analysis. Water was sampled on rearing day 30 during a 24-h cycle in both treatments. Postlarvae from the ICES treatment were weaned, though by the end of the experiment the Artemia treatment exhibited significantly higher values for growth, RGR, K and survival rates (P < 0.05). No significant differences were observed concerning total lipid content. Protein content was significantly higher for the Artemia treatment after 46 days of rearing (P < 0.05). The total ammonia nitrogen concentration in the water increased after each meal and remained below a harmless level for postlarvae.info:eu-repo/semantics/publishedVersio

Weaning of Senegalese sole (Solea senegalensis) postlarvae to an inert diet with a co-feeding regime | Destete de postlarvas del lenguado senegalés (Solea senegalensis) a una dieta inerte utilizando un régimen de coalimentación

The objective of this study was to evaluate the weaning success of Senegalese sole, Solea senegalensis, postlarvae when cofed a compound diet, by means of the analysis of growth parameters (relative growth rate [RGR] and condition factor [K]), survival, protein and lipid content. Total ammonia in the rearing water was also measured. The experiment lasted for 46 days (36 to 82 days posthatching). One group was fed only with enriched Artemia sp. metanauplii (Artemia treatment), whereas in another group, the Artemia sp. metanauplii were gradually replaced by the International Council for the Exploration of the Sea (ICES) diet over a period of 39 days (ICES treatment). Postlarvae were sampled on rearing days 0, 9, 23, 30, 39 and 46 for growth and biochemical analysis. Water was sampled on rearing day 30 during a 24-h cycle in both treatments. Postlarvae from the ICES treatment were weaned, though by the end of the experiment the Artemia treatment exhibited significantly higher values for growth, RGR, K and survival rates (P <0.05). No significant differences were observed concerning total lipid content. Protein content was significantly higher for the Artemia treatment after 46 days of rearing (P < 0.05). The total ammonia nitrogen concentration in the water increased after each meal and remained below a harmless level for postlarvae.El objetivo de este estudio consistió en evaluar el éxito del destete de postlarvas del lenguado senegalés, Solea senegalensis, utilizando un régimen de coalimentación. El estudio se realizó mediante el análisis de parámetros de crecimiento (tasa de crecimiento relativa [RGR] y factor de condición [K]), supervivencia y contenido de proteínas y lípidos. La concentración del amonio total en el agua de cultivo también fue analizada. El experimento se realizó durante 46 días (de 36 a 82 días posteclosión). Un grupo de postlarvas se alimentó únicamente con metanauplios de Artemia sp. enriquecidos (tratamiento con Artemia), mientras que en otro grupo los metanauplius de Artemia sp. fueron gradualmente substituidos por la dieta del International Council for the Exploration of the Sea (tratamiento ICES) durante un periodo de 39 días. Las postlarvas se muestrearon durante los días 0, 9, 23, 30, 39 y 46 de cultivo para el estudio de crecimiento y el análisis bioquímico Las muestras de agua se tomaron el día 30 de cultivo durante un ciclo de 24 h en ambos tratamientos. Las postlarvas del tratamiento ICES fueron destetadas, aunque al final del experimento se registraron valores significativamente mayores en relación al crecimiento, RGR, K y tasas de supervivencia (P < 0.05) en el tratamiento con Artemia. No se observaron diferencias significativas en el contenido total de lípidos. El contenido de proteínas fue significativamente mayor en el tratamiento con Artemia a los 46 días de cultivo (P < 0.05). La concentracion de amonio total en el agua se incrementó después de cada toma de alimento pero se mantuvo por debajo del nivel tóxico para las postlarvas de peces marinos

Regulation of HPV transcription

Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on their association with the development of cervical carcinoma. High-risk human papillomavirus 16 and 18 are detected in 55% and 15% of all invasive cervical squamous cell carcinomas worldwide, respectively. Low-risk human papillomavirus 6 and 11 are responsible for 90% of genital warts and are also associated with the development of recurrent respiratory papillomatosis. Human papillomavirus preferentially infects mitotic active cells of the basal layer from both mucosal and cutaneous epithelium through microabrasions. The viral life cycle synchronizes with the epithelial differentiation program, which may be due, in part, to the binding of differentially expressed cellular transcription factors to the long control region throughout the various epithelial layers. This review aimed to summarize the current knowledge regarding the mechanisms by which viral gene expression is regulated and the influence of human papillomavirus heterogeneity upon this phenomenon. A better understanding of the regulatory mechanisms may elucidate the particularities of human papillomavirus-associated pathogenesis and may provide new tools for antiviral therapy

Marketing public art: using project based learning to teach creativity and entrepreneurship

This paper deals with the pedagogical aspects of a collective project carried out by students of the MISB programme at ISCAP, as well as describes its design, methodology, management and outcomes. In addition, it focuses on (1) Project management issues related to the Google Arts&Culture Platform; (2) Criteria and methodology definition; (3) Information regarding the collection contained in the Santo Tirso International Museum of Contemporary Sculpture; (4) Pedagogical considerations and outcomes.Este artigo descreverá as questões pedagógicas subjacentes a um projeto levado a cabo por alunos do MISB lecionado no ISCAP, refletindo sobre seu design, metodologia, gestão e resultados, com foco em (1) Questões de gestão de projetos, relacionadas com a plataforma Google Arts&Culture; (2) Critérios e definição da metodologia; (3) Informação sobre a coleção do Museu Internacional de Escultura Contemporânea de Santo Tirso; (4) Reflexão e resultados pedagógicos.info:eu-repo/semantics/publishedVersio

Elemental characterization of the airborne pollen surface using Electron Probe Microanalysis (EPMA)

Recent worldwide increase in pollinoses has been attributed to the synergy between pollen and pollutants. We used EPMA for the elemental characterization of the airborne pollen surface in order to find out what occurs to the wall of pollen grains when they are together with other atmospheric pollutants. Analyses were performed both to airborne pollen and to pollen that was collected from Acer spp., Platanus spp. and Pinus spp. trees. Airborne samples were assembled using a Hirst-type volumetric spore sampler set in the coastal city of Porto, Portugal. Airborne pollen samples showed major elemental differences when compared to the control pollen sample of the same species, namely in the amounts of Cl, Na and Mg, which very significantly increased on airborne samples, revealing an important influence of the ocean. Mineral dust also contributed to modify the pollen surface, by increasing Si contents on Acer spp. and Platanus spp. airborne pollen. Our results revealed consistent positive effects of the relative humidity and the precipitation in the increase of Cl, Na and Mg relative amounts on the pollen surface. This study shows that pollen grains have the ability to adsorb and/or absorb other materials, which may contribute to enhance pollen's harmful effects on people's health

Impacts of IoT in the information systems project management

A Internet of Things (IoT) representa um novo paradigma de integração de várias tecnologias e soluções de comunicação, encontrando aplicações em muitos domínios diferentes, tais como a agricultura, a saúde, os edifícios e cidades inteligentes, a segurança e a vigilância, e em muitas outras áreas. Uma área a estudar no âmbito da IoT é a de gestão de projetos de tecnologias e sistemas de informação. A gestão de projetos aplica conhecimentos, competências e técnicas na realização de atividades relacionadas com um conjunto de objetivos pré-definidos, num certo prazo, com um certo custo e qualidade, através da mobilização de recursos técnicos e humanos. A IoT pode ter um papel importante ao possibilitar a criação de novas ferramentas para melhoria dos processos e técnicas da gestão de projetos. A questão que este trabalho procura responder é: Quais os impactos potenciais da IoT na melhoria da gestão de projetos?The Internet of Things (IoT) represents a new paradigm of integration of various communication technologies and solutions, having applications in many domains, such as agriculture, health, smart buildings and cities, security and surveillance, and in many other areas. One area of application that should be studied in the scope of IoT is the management of information systems projects. Project management applies knowledge, skills and techniques for carrying out activities related to a set of predefined objectives, in a certain period, with a certain cost and quality, through the mobilization of technical and human resources. IoT can play an important role by enabling the creation of new tools for improving the processes and techniques of project management. Our research question is: What are the potential impacts of IoT for project management improvement?This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2013.info:eu-repo/semantics/publishedVersio