Prospects for the CERN Axion Solar Telescope Sensitivity to 14.4 keV Axions

The CERN Axion Solar Telescope (CAST) is searching for solar axions using the 9.0 T strong and 9.26 m long transverse magnetic field of a twin aperture LHC test magnet, where axions could be converted into X-rays via reverse Primakoff process. Here we explore the potential of CAST to search for 14.4 keV axions that could be emitted from the Sun in M1 nuclear transition between the first, thermally excited state, and the ground state of 57Fe nuclide. Calculations of the expected signals, with respect to the axion-photon coupling, axion-nucleon coupling and axion mass, are presented in comparison with the experimental sensitivity.Comment: 4 pages, 1 figure. Submitted to Nucl. Instr. and Meth.

Search for solar axion emission from 7Li and D(p,gamma)3He nuclear decays with the CAST gamma-ray calorimeter

We present the results of a search for a high-energy axion emission signal from 7Li (0.478 MeV) and D(p,gamma)3He (5.5 MeV) nuclear transitions using a low-background gamma-ray calorimeter during Phase I of the CAST experiment. These so-called "hadronic axions" could provide a solution to the long-standing strong-CP problem and can be emitted from the solar core from nuclear M1 transitions. This is the first such search for high-energy pseudoscalar bosons with couplings to nucleons conducted using a helioscope approach. No excess signal above background was found.Comment: 20 pages, 8 figures, final version to be published in JCA

A candidate super-Earth planet orbiting near the snow line of Barnard’s star

Barnard’s star is a red dwarf, and has the largest proper motion (apparent motion across the sky) of all known stars. At a distance of 1.8 parsecs, it is the closest single star to the Sun; only the three stars in the α Centauri system are closer. Barnard’s star is also among the least magnetically active red dwarfs known and has an estimated age older than the Solar System. Its properties make it a prime target for planetary searches; various techniques with different sensitivity limits have been used previously, including radial-velocity imaging, astrometry and direct imaging, but all ultimately led to negative or null results. Here we combine numerous measurements from high-precision radial-velocity instruments, revealing the presence of a low-amplitude periodic signal with a period of 233 days. Independent photometric and spectroscopic monitoring, as well as an analysis of instrumental systematic effects, suggest that this signal is best explained as arising from a planetary companion. The candidate planet around Barnard’s star is a cold super-Earth, with a minimum mass of 3.2 times that of Earth, orbiting near its snow line (the minimum distance from the star at which volatile compounds could condense). The combination of all radial-velocity datasets spanning 20 years of measurements additionally reveals a long-term modulation that could arise from a stellar magnetic-activity cycle or from a more distant planetary object. Because of its proximity to the Sun, the candidate planet has a maximum angular separation of 220 milliarcseconds from Barnard’s star, making it an excellent target for direct imaging and astrometric observations in the future. © 2018, Springer Nature Limited.The results are based on observations made with the CARMENES instrument at the 3.5-m telescope of the Centro Astronomico Hispano-Aleman de Calar Alto (CAHA, Almeria, Spain), funded by the German Max-Planck-Gesellschaft (MPG), the Spanish Consejo Superior de Investigaciones Cientificas (CSIC), the European Union and the CARMENES Consortium members; the 90-cm telescope at the Sierra Nevada Observatory (Granada, Spain) and the 40-cm robotic telescope at the SPACEOBS observatory (San Pedro de Atacama, Chile), both operated by the Instituto de Astrofisica de Andalucia (IAA); and the 80-cm Joan Oro Telescope (TJO) of the Montsec Astronomical Observatory (OAdM), owned by the Generalitat de Catalunya and operated by the Institute of Space Studies of Catalonia (IEEC). This research was supported by the following institutions, grants and fellowships: Spanish MINECO ESP2016-80435-C2-1-R, ESP2016-80435-C2-2-R, AYA2016-79425-C3-1-P, AYA2016-79245-C3-2-P, AYA2016-79425-C3-3-P, AYA2015-69350-C3-2-P, ESP2014-54362-P, AYA2014-56359-P, RYC-2013-14875; Generalitat de Catalunya/CERCA programme; Fondo Europeo de Desarrollo Regional (FEDER); German Science Foundation (DFG) Research Unit FOR2544, project JE 701/3-1; STFC Consolidated Grants ST/P000584/1, ST/P000592/1, ST/M001008/1; NSF AST-0307493; Queen Mary University of London Scholarship; Perren foundation grant; CONICYT-FONDECYT 1161218, 3180405; Swiss National Science Foundation (SNSF); Koshland Foundation and McDonald-Leapman grant; and NASA Hubble Fellowship grant HST-HF2-51399.001. J.T. is a Hubble Fellow

Effectiveness of an mHealth intervention combining a smartphone app and smart band on body composition in an overweight and obese population: Randomized controlled trial (EVIDENT 3 study)

Background: Mobile health (mHealth) is currently among the supporting elements that may contribute to an improvement in health markers by helping people adopt healthier lifestyles. mHealth interventions have been widely reported to achieve greater weight loss than other approaches, but their effect on body composition remains unclear. Objective: This study aimed to assess the short-term (3 months) effectiveness of a mobile app and a smart band for losing weight and changing body composition in sedentary Spanish adults who are overweight or obese. Methods: A randomized controlled, multicenter clinical trial was conducted involving the participation of 440 subjects from primary care centers, with 231 subjects in the intervention group (IG; counselling with smartphone app and smart band) and 209 in the control group (CG; counselling only). Both groups were counselled about healthy diet and physical activity. For the 3-month intervention period, the IG was trained to use a smartphone app that involved self-monitoring and tailored feedback, as well as a smart band that recorded daily physical activity (Mi Band 2, Xiaomi). Body composition was measured using the InBody 230 bioimpedance device (InBody Co., Ltd), and physical activity was measured using the International Physical Activity Questionnaire. Results: The mHealth intervention produced a greater loss of body weight (–1.97 kg, 95% CI –2.39 to –1.54) relative to standard counselling at 3 months (–1.13 kg, 95% CI –1.56 to –0.69). Comparing groups, the IG achieved a weight loss of 0.84 kg more than the CG at 3 months. The IG showed a decrease in body fat mass (BFM; –1.84 kg, 95% CI –2.48 to –1.20), percentage of body fat (PBF; –1.22%, 95% CI –1.82% to 0.62%), and BMI (–0.77 kg/m2, 95% CI –0.96 to 0.57). No significant changes were observed in any of these parameters in men; among women, there was a significant decrease in BMI in the IG compared with the CG. When subjects were grouped according to baseline BMI, the overweight group experienced a change in BFM of –1.18 kg (95% CI –2.30 to –0.06) and BMI of –0.47 kg/m2 (95% CI –0.80 to –0.13), whereas the obese group only experienced a change in BMI of –0.53 kg/m2 (95% CI –0.86 to –0.19). When the data were analyzed according to physical activity, the moderate-vigorous physical activity group showed significant changes in BFM of –1.03 kg (95% CI –1.74 to –0.33), PBF of –0.76% (95% CI –1.32% to –0.20%), and BMI of –0.5 kg/m2 (95% CI –0.83 to –0.19). Conclusions: The results from this multicenter, randomized controlled clinical trial study show that compared with standard counselling alone, adding a self-reported app and a smart band obtained beneficial results in terms of weight loss and a reduction in BFM and PBF in female subjects with a BMI less than 30 kg/m2 and a moderate-vigorous physical activity level. Nevertheless, further studies are needed to ensure that this profile benefits more than others from this intervention and to investigate modifications of this intervention to achieve a global effect

Probing eV-scale axions with CAST

We have searched for solar axions or other pseudoscalar particles that couple to two photons by using the CERN Axion Solar Telescope (CAST) setup. Whereas we previously have reported results from CAST with evacuated magnet bores (Phase I), setting limits on lower mass axions, here we report results from CAST where the magnet bores were filled with \hefour gas (Phase II) of variable pressure. The introduction of gas generated a refractive photon mass $m_\gamma$, thereby achieving the maximum possible conversion rate for those axion masses \ma that match $m_\gamma$. With 160 different pressure settings we have scanned \ma up to about 0.4 eV, taking approximately 2 h of data for each setting. From the absence of excess X-rays when the magnet was pointing to the Sun, we set a typical upper limit on the axion-photon coupling of \gag\lesssim 2.17\times 10^{-10} {\rm GeV}^{-1} at 95% CL for \ma \lesssim 0.4 eV, the exact result depending on the pressure setting. The excluded parameter range covers realistic axion models with a Peccei-Quinn scale in the neighborhood of $f_{\rm a}\sim10^{7}$ GeV. Currently in the second part of CAST Phase II, we are searching for axions with masses up to about 1.2 eV using \hethree as a buffer gas.Comment: 18 pages, 7 figures. Revised version of the paper after referee's comments. Main changes on the gas sectio

The CARMENES search for exoplanets around M dwarfs. Stellar atmospheric parameters of target stars with STEPARSYN

We determined effective temperatures, surface gravities, and metallicities for a sample of 343 M dwarfs observed with CARMENES, the double-channel, high-resolution spectrograph installed at the 3.5 m telescope at Calar Alto Observatory. We employed STEPARSYN, a Bayesian spectral synthesis implementation particularly designed to infer the stellar atmospheric parameters of late-type stars following a Markov chain Monte Carlo approach. We made use of the BT-Settl model atmospheres and the radiative transfer code turbospectrum to compute a grid of synthetic spectra around 75 magnetically insensitive Fe I and Ti I lines plus the TiO γ and ∈ bands. To avoid any potential degeneracy in the parameter space, we imposed Bayesian priors on Teff and logg based on the comprehensive, multi-band photometric data available for the sample. We find that this methodology is suitable down to M7.0 V, where refractory metals such as Ti are expected to condense in the stellar photospheres. The derived Teff, logg, and [Fe/H] range from 3000 to 4200 K, 4.5 to 5.3 dex, and -0.7 to 0.2 dex, respectively. Although our Teff scale is in good agreement with the literature, we report large discrepancies in the [Fe/H] scales, which might arise from the different methodologies and sets of lines considered. However, our [Fe/H] is in agreement with the metallicity distribution of FGK-type stars in the solar neighbourhood and correlates well with the kinematic membership of the targets in the Galactic populations. Lastly, excellent agreement in Teff is found for M dwarfs with interferometric angular diameter measurements, as well as in the [Fe/H] between the components in the wide physical FGK+M and M+M systems included in our sample. © 2021 ESO.CARMENES is an instrument for the Centro Astronomico Hispano en Andalucia at Calar Alto (CAHA). CARMENES is funded by the German Max-Plank Gesellschaft (MPG), the Spanish Consejo Superior de Investigaciones Cientificas (CSIC), the European Union through FEDER/ERF FICTS-2011-02 funds, and the members of the CARMENES Consortium (Max-Plank-Institut fur Astronomie, Instituto de Astrofisica de Andalucia, Landessternwarte Konigstuhl, Institut de Ciences de l'Espai, Institut fur Astrophysik Gottingen, Universidad Complutense de Madrid, Thuringer Landessternwarte Tautenberg, Instituto de Astrofisica de Canarias, Hamburger Sternwarte, Centro de Astrobiologia and Centro Astronomico Hispano-Andaluz), with additional contributions by the Spanish Ministry of Economy, the German Science Foundation through the Major Research Instrumentation Programme and DFG Research Unit FOR2544 "Blue Planets around Red Stars", the Klaus Tschira Stiftung, the states of BadenWurttemberg and Niedersachsen, and by the Junta de Andalucia. The authors acknowledge financial support from the Fundação para a Ciência e a Tecnologia (FCT) through the research grants UID/FIS/04434/2019, UIDB/04434/2020 and UIDP/04434/2020, national funds PTDC/FIS-AST/28953/2017, by FEDER (Fundo Europeu de Desenvolvimento Regional) through COMPETE2020 Programa Operacional Competitividade e Internacionalizacao (POCI-01-0145FEDER-028953), and the Spanish Ministerio de Ciencia, Innovacion y Universidades, Ministerio de Economia y Competitividad, the Universidad Complutense de Madrid, and the Fondo Europeo de Desarrollo Regional (FEDER/ERF) through fellowship FPU15/01476, and projects AYA2016-79425-C3-1/2/3-P, PID2019-109522GB-C5[1:4]/AEI/10.13039/501100011033, AYA2014-56359-P, BES-2017-080769, and RYC-2013-14875. The authors also acknowledge financial support from the Centre of Excellence "Severo Ochoa" and "Maria de Maeztu" awards to the Instituto de Astrofisica de Canarias (SEV-2015-0548), Instituto de Astrofisica de Andalucia (SEV-2017-0709), and Centro de Astrobiologia (MDM-2017-0737), and the Generalitat de Catalunya/CERCA programme. This work has made use of the VALD database, operated at Uppsala University, the Institute of Astronomy RAS in Moscow, and the University of Vienna, and of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. V.M.P. acknowledges financial support from NASA through grant NNX17AG24G. S.V.J. acknowledges the support of the DFG priority program SPP 1992 "Exploring the Diversity of Extrasolar Planets" (JE 701/5-1). E.M. would also like to warmly thank the staff at the Hamburger Sternwarte for their hospitality during his stay funded by project EST18/00162. Based on data from the CARMENES data archive at CAB (INTA-CSIC).Peer reviewe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele