Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes

The results of the first study characterizing new high-lycopene tomato advanced breeding lines, to determine the phytochemical content as well asin vitroantioxidant activities of peel, pulp and seed fractions are presented.</p

Réactions systémiques après traitement endovésical par le BCG : à propos de 4 cas

International audienceLocal Bacillus Calmette-Guerin (BCG) immunotherapy is an effective and widely used treatment for superficial bladder carcinoma. Local side effects are frequent, whereas systemic side effects are rare, but more serious. We report four cases of systemic BCG reaction. Although uncommon, this infectious complication of BCG therapy should always be considered in the appropriate clinical setting. The best approach to minimize this complication is a strict compliance with precautions and a close and rigorous surveillance of this drug.L'efficacité anti-tumorale de la BCG-thérapie endovésicale dans le traitement de la tumeur superficielle de la vessie est actuellement bien établie. Néanmoins, les réactions systémiques au BCG demeurent l'effet secondaire le plus redoutable. L'apparition de quatre cas de réaction systémique au BCG dont trois survenus en 2003 nous a incité à ré-étudier les signes cliniques et biologiques de cette complication ainsi que les facteurs favorisant son apparition. La difficulté de manier la BCG-thérapie endovésicale et la gravité de ses complications impose le respect scrupuleux des bonnes pratiques de conduite du traitement et des recommandations en vigueur afin de limiter la survenue des réactions systémiques au BCG. Celles-ci doivent être dépister le plus précocement possible afin d'éviter les conséquences qui peuvent être redoutables

‘No place for a woman’: Access, exclusion, insecurity and the mobility regime in grand tunis

Drawing on an innovative peer researcher method, this paper uses mobility diaries and in-transit interviews to examine the everyday travel experiences of women from socio-economically marginalised neighbourhoods in metropolitan Grand Tunis. It situates those experiences, and the practices they deploy to navigate them, within a meso-level discussion of women’s social condition in Tunisia and a macro-level political economy of the Tunis transport system. Together these shed light on the multi-layered intersecting disadvantages which shape women’s place in the prevailing mobility regime, pushing already marginalised women into transport poverty and social exclusion. The paper highlights the subsequent constraints on women’s access to the resources which might allow them to improve their lives, and the significance of travel-related violence and insecurity on their everyday lives

Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness.

Identification of the causative mutations in patients affected by autosomal recessive non syndromic deafness (DFNB forms), is demanding due to genetic heterogeneity. After the exclusion of GJB2 mutations and other mutations previously reported in Tunisian deaf patients, we performed whole exome sequencing in patients affected with severe to profound deafness, from four unrelated consanguineous Tunisian families. Four biallelic non previously reported mutations were identified in three different genes: a nonsense mutation, c.208C>T (p.R70X), in LRTOMT, a missense mutation, c.5417T>C (p.L1806P), in MYO15A and two splice site mutations, c.7395+3G>A, and c.2260+2T>A, in MYO15A and TMC1 respectively. We thereby provide evidence that whole exome sequencing is a powerful, cost-effective screening tool to identify mutations causing recessive deafness in consanguineous families

Biallelic mutations identified in DFNB genes using a whole exome sequencing strategy.

<p>Biallelic mutations identified in DFNB genes using a whole exome sequencing strategy.</p

Evolution of the number of variants during whole exome.

<p>Evolution of the number of variants during whole exome.</p

Pedigrees of the four Tunisian families analyzed using the whole exome sequencing strategy.

<p>Pedigrees of the four Tunisian families analyzed using the whole exome sequencing strategy.</p

Sequences of the primers used to validate the mutations by Sanger sequencing.

<p>Sequences of the primers used to validate the mutations by Sanger sequencing.</p