5,339 research outputs found
Time--Splitting Schemes and Measure Source Terms for a Quasilinear Relaxing System
Several singular limits are investigated in the context of a
system arising for instance in the modeling of chromatographic processes. In
particular, we focus on the case where the relaxation term and a
projection operator are concentrated on a discrete lattice by means of Dirac
measures. This formulation allows to study more easily some time-splitting
numerical schemes
Einstein Cluster Alignments Revisited
We have examined whether the major axes of rich galaxy clusters tend to point
toward their nearest neighboring cluster. We have used the data of Ulmer,
McMillan, and Kowalski, who used position angles based on X-ray morphology. We
also studied a subset of this sample with updated positions and distances from
the MX Northern Abell Cluster Survey (for rich clusters () with well
known redshifts). A Kolmogorov-Smirnov (KS) test showed no significant signal
for nonrandom angles on any scale Mpc. However, refining the
null hypothesis with the Wilcoxon rank-sum test, we found a high confidence
signal for alignment. Confidence levels increase to a high of 99.997% as only
near neighbors which are very close are considered. We conclude there is a
strong alignment signal in the data, consistent with gravitational instability
acting on Gaussian perturbations.Comment: Minor revisions. To be published in Ap
The Ellipticity and Orientation of Clusters of Galaxies from N-Body Experiments
In this study we use simulations of 128 particles to study the
ellipticity and orientation of clusters of galaxies in N-body simulations of
differing power-law initial spectra (P(k) \propto k^n ,n = +1, 0, -1, -2\Omega_0 = 0.2nD < 15 h^{-1}n-$dependent way.Comment: 22 pages, requires aaspp4.sty, flushrt.sty, and epsf.sty Revised
manuscript, accepted for publication in Ap
Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia
Objectives: Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications. We evaluated the bronchopulmonary pharmacokinetic/pharmacodynamic profile of this 3 g ceftolozane/tazobactam regimen in ventilated pneumonia patients.
Methods: This was an open-label, multicentre, Phase 1 trial (clinicaltrials.gov: NCT02387372). Mechanically ventilated patients with proven/suspected pneumonia received four to six doses of 3 g of ceftolozane/tazobactam (adjusted for renal function) q8h. Serial plasma samples were collected after the first and last doses. One bronchoalveolar lavage sample per patient was collected at 1, 2, 4, 6 or 8 h after the last dose and epithelial lining fluid (ELF) drug concentrations were determined. Pharmacokinetic parameters were estimated by noncompartmental analysis and pharmacodynamic analyses were conducted to graphically evaluate achievement of target exposures (plasma and ELF ceftolozane concentrations >4 mg/L and tazobactam concentrations >1 mg/L; target in plasma: similar to 30% and similar to 20% of the dosing interval, respectively).
Results: Twenty-six patients received four to six doses of study drug; 22 were included in the ELF analyses. Ceftolozane and tazobactam T-max (6 and 2 h, respectively) were delayed in ELF compared with plasma (1h). Lung penetration, expressed as the ratio of mean drug exposure (AUC) in ELF to plasma, was 50% (ceftolozane) and 62% (tazobactam). Mean ceftolozane and tazobactam ELF
concentrations remained >4 mg/L and >1mg/L, respectively, for 100% of the dosing interval. Therewere no deaths or adverse event-related study discontinuations. Conclusions: In ventilated pneumonia patients, 3 g of ceftolozane/tazobactam q8h yielded ELF exposures considered adequate to cover ceftolozane/tazobactam-susceptible respiratory pathogens
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Gastric Extremely Well-Diferentiated Intestinal-Type Adenocarcinoma: A Challenging Lesion to Achieve Complete Endoscopic Resection
Extremely well-differentiated tubular adenocarcinomas (EWDAs) of the stomach are characterized by surface maturation and their mimicking of intestinal metaplasia. Endoscopically, intramucosal EWDAs are frequently ill defined with indistinct borders due to the pallor of the neoplastic mucosa and the lack of contrast against the background atrophic and metaplastic mucosa. We evaluated the effectiveness of endoscopic resection for EWDAs after endoscopic submucosal dissection (ESD).
Among 872 patients with early gastric cancer, 17 EWDAs were identified (1.9â%). Endoscopically, the flat or depressed type was significantly more common among EWDAs (88.2â%) than among early gastric cancers of other histologies (37.8â%; Pâ<â0.01). The discrepancy between endoscopically estimated tumor size and tumor size as confirmed in pathology reports was significantly greater among EWDAs (18.4â±â22.0âmm) than among others (5.8â±â7.5âmm). Involvement of the lateral resection margin was more common (29.4â% vs. 2.5â%; Pâ<â0.05), and complete resection was achieved less often in EWDAs (47.1â% vs. 80.4â%; Pâ=â0.01) compared to the others.
EWDAs are associated with higher rates of incomplete resection after ESD, especially along the lateral margins. Pathologists should alert endoscopists when this diagnosis is made, with its associated risks; and endoscopists should pay particular attention to the extent of these tumors during resection
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âIf you look the part youâll get the jobâ: should career professionals help clients to enhance their career image?
This article presents a critical exploration of the role of career professionals in supporting people to reflect on and enhance their appearance, attractiveness and self-presentation (career image). The article is conceptual and based on a review of the broader literature on career success, appearance and attractiveness. It explores the evidence for a relationship between attractiveness and career, and the authors propose a conceptual framework in which career image is comprised of three elements (interpersonal skills, aesthetic presentation and beauty). The paper examines a possible role for career professionals in relation to this and then critically examines this role and concludes with the proposition of a research agenda in this area
Glucose metabolism and oscillatory behavior of pancreatic islets
A variety of oscillations are observed in pancreatic islets.We establish a
model, incorporating two oscillatory systems of different time scales: One is
the well-known bursting model in pancreatic beta-cells and the other is the
glucose-insulin feedback model which considers direct and indirect feedback of
secreted insulin. These two are coupled to interact with each other in the
combined model, and two basic assumptions are made on the basis of biological
observations: The conductance g_{K(ATP)} for the ATP-dependent potassium
current is a decreasing function of the glucose concentration whereas the
insulin secretion rate is given by a function of the intracellular calcium
concentration. Obtained via extensive numerical simulations are complex
oscillations including clusters of bursts, slow and fast calcium oscillations,
and so on. We also consider how the intracellular glucose concentration depends
upon the extracellular glucose concentration, and examine the inhibitory
effects of insulin.Comment: 11 pages, 16 figure
The HI Content of Local Late-Type Galaxies
We present a solid relationship between the neutral hydrogen (HI) disk mass
and the stellar disk mass of late-type galaxies in the local universe. This
relationship is derived by comparing the stellar disk mass function from the
Sloan Digital Sky Survey and the HI mass function from the HI Parkes All Sky
Survey (HIPASS). We find that the HI mass in late-type galaxies tightly
correlates with the stellar mass over three orders of magnitude in stellar disk
mass. We cross-check our result with that obtained from a sample of HIPASS
objects for which the stellar mass has been obtained by inner kinematics. In
addition, we derive the HI versus halo mass relationship and the dependence of
all the baryonic components in spirals on the host halo mass. These
relationships bear the imprint of the processes ruling galaxy formation, and
highlight the inefficiency of galaxies both in forming stars and in retaining
their pristine HI gas.Comment: 6 pages, 5 figures. Match to the published version. References
update
A Search for Extraplanar Dust in Nearby Edge-On Spirals
We present high resolution BV images of 12 edge-on spiral galaxies observed
with the WIYN 3.5-m telescope. These images were obtained to search for
extraplanar (|z| > 0.4 kpc) absorbing dust structures similar to those
previously found in NGC 891 (Howk & Savage 1997). Our imaged galaxies include a
sample of seven massive L_*-like spiral galaxies within D<25 Mpc that have
inclinations i > 87 deg from the plane of the sky. We find that five of these
seven systems show extraplanar dust, visible as highly-structured absorbing
clouds against the background stellar light of the galaxies. The more prominent
structures are estimated to have associated gas masses >10^5 M_sun; the implied
potential energies are > 10^(52) ergs. All of the galaxies in our sample that
show detectable halpha emission at large z also show extraplanar dust
structures. None of those galaxies for which extraplanar halpha searches were
negative show evidence for extensive high-z dust. The existence of extraplanar
dust is a common property of massive spiral galaxies. We discuss several
mechanisms for shaping the observed dust features, emphasizing the possibility
that these dusty clouds represent the dense phase of a multiphase medium at
high-z in spiral galaxies. The correlation between high-z dust and extraplanar
Halpha emission may simply suggest that both trace the high-z interstellar
medium in its various forms (or phases), the existence of which may ultimately
be driven by vigorous star formation in the underlying disk. (Abstract
abridged)Comment: 26 pages; 15 jpeg figures. To appear in The Astronomical Journal, May
1999. Gzipped tar files of high-resolution figures in postscript and jpeg
formats are available at
http://www.astro.wisc.edu/~howk/Papers/papers.html#surve
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