Spaceborne Fiber Optic Data Bus (SFODB)

The SFODB is a standardized, gigabit per second, highly reliable, fault tolerant fiber optic network. SFODB was designed to the harsh space environments and real-time, on-board data handling applications of high speed, remote sensing spacecraft

Spaceborne Fiber Optic Data Bus (SFODB)

Spaceborne Fiber Optic Data Bus (SFODB) is an IEEE 1393 compliant, gigabit per second, fiber optic network specifically designed to support the real-time, on-board data handling requirements of remote sensing spacecraft. The network is fault tolerant highly reliable, and capable of withstanding the rigors of launch and the harsh space environment. SFODB achieves this operational and environmental performance while maintaining the small size, light weight, and low power necessary for spaceborne applications. On December 9, 1998, SFODB was successfully demonstrated at NASA's Goddard Space Flight Center (GSFC)

High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs

Intrathecal (IT) gene transfer using adeno-associated virus (AAV) may be clinically promising as a treatment for chronic pain if it can produce sufficiently high levels of a transgene product in the cerebrospinal fluid (CSF). While this strategy was developed in rodents, no studies investigating CSF levels of an analgesic or anti-allodynic protein delivered by IT AAV have been performed in large animals. Interleukin-10 (IL-10) is an anti-allodynic cytokine, for which target therapeutic levels have been established in rats. The present study tested IT AAV8 encoding either human IL-10 (hIL-10) or enhanced green fluorescent protein (EGFP) in a dog model of IT drug delivery. AAV8/hIL-10 at a dose of 3.5×10(12) genome copies induced high hIL-10 levels in the CSF, exceeding the target concentration previously found to be anti-allodynic in rodents by >1000-fold. AAV8/EGFP targeted the primary sensory and motor neurons and the meninges. hIL-10, a xenogeneic protein in dogs, induced anti-hIL-10 antibodies detectable in the dogs’ CSF and serum. The high hIL-10 levels demonstrate the efficacy of AAV for delivery of secreted transgenes into the IT space of large animals suggesting a strong case for further development towards clinical testing