Self-rated health and internet addiction in Iranian medical sciences students; prevalence, risk factors and complications

Introduction: Self-rated health is a brief measure for general health. It is a comprehensive and sensitive index for prediction of health in future. Due to the high internet usage in medical students, the current study designed to evaluate the self-rated health (SR H) in relationship with internet addiction risk factors in medical students. Methods: This cross sectional study conducted on 254 students of Qom University of Medical Sciences 2014. Participants selected by two stage sampling method including stratified and simple random sampling. The Young’s questionnaire of internet addiction and SR H question used for data collection. Chisquare, t-test, and logistic regression used in data analysis. Results: More than 79.9% of students reported their general health good and very good. The student’s mean score of general health was higher than the average. In addition, the prevalence of internet addiction was 28.7%. An inverse significant correlation observed between SR H and internet addiction score (r=-0.198, p=0.002). Using internet for Entertainment, using private Email and chat rooms were the most important predictors of affecting to internet addiction. Moreover, internet addiction is the most predictors of SR H and increased the odds of bad SR H. Conclusion: The good SR H of medical students was higher than general population but in health faculty’ students were lower than others. Due to the effect of internet addiction on SRH and increasing trend of internet use in medical students, as well as low age of participants, attention to psychological aspects and the job expectancy in future, can effective on increasing the good SRH

The study of Health Literacy of adults in Karaj

Background and objective: Health literacy represents the cognitive and social skills that determine the motivation and ability of individuals to acquire, access and understand the information to maintain and promote health. This study aimed to assess the health literacy of adults in Karaj. Methods: In this cross-sectional and descriptive study, 525 subjects aged 18-65 years old were selected using multistage sampling in Karaj. Relevant information was obtained using demographic questionnaire and HELIA questionnaire (18-65 years-old), respectively. Data were analyzed using SPSS and appropriate tests. Results: The mean age of participants was 33.48 ± 11.39 years old. 48.8% (n=250) the participants were male and 51.2% (n=262) were female. 24.2% (n=124) of the participants had inadequate health literacy, 23.4 % (n=120) not so inadequate health literacy, 37.9 % (n=194) adequate health literacy and 14.5 (n = 74) had higher health literacy. Health literacy was significantly associated with age, gender, marital status, education, BMI, smoking and physical activity (

Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine

Abstract Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach to solid support and acting as promoters in organic transformations. In this work, captopril was attached to the surface of magnetic graphene nitride by employing a linker agent. The synthesized composite efficiently catalyzed two multicomponent reactions including the synthesis of 1,2,3,6-tetrahydropyrimidine and 2-amino-4H-chromene derivatives. A large library of functional targeted products was synthesized in mild reaction conditions. More importantly, this catalyst was stable and magnetically recycled and reused for at least five runs without losing catalytic activity

A Genetic Variant of KOZAK Region in Annexin-V Gene in Premature Myocardial Infarction: A Case Control Study

Purpose: Atherosclerosis is the major underlying cause of cardiovascular diseases. Recently has been revealed a genetic role in the occurrence of coronary artery disease (CAD). Annexin V is one of the genes which may play roles in early-onset CAD and has anti-coagulatory roles. The aim of this study was to determine the association between -1C>T polymorphism of KOZAK region in annexin-V gene and premature CAD. Methods: This case-control study was done on 100 patients with premature acute myocardial infarction, patients matched with healthy people with sex and age-matched and some other cardiovascular risk factor. Genomic DNA was extracted from WBC and then the polymorphism was genotyped using PCR-RFLP method. The collected data were analyzed by SPSS. Significant findings: There was no significant difference between genotypes of annexin-V gene and occurrence of premature CAD (P = 0.840) and there is a significant difference between alleles of the annexin-V gene (C and T) and occurrence of premature CAD in case and control groups (P = 0.013). Conclusions: According to the results derived from this study, it seems like the existence of the genotype carrying the mutated allele (CT+TT) in -1C>T of KOZAK region in the annexin-V gene is not associated with an increased risk of premature myocardial infarction

Mycophenolate mofetil versus cyclophosphamide for idiopathic membranous nephropathy; a double blind and randomized clinical trial

Introduction: The current treatment regimens for patients with idiopathic membranous nephropathy (MN) are based on cyclophosphamide-glucocorticoid or calcineurin inhibitor-glucocorticoid. Objectives: We evaluated whether mycophenolate mofetil (MMF) -glucocorticoid could be an option for first-line therapy among these patients. Patients and Methods: In a double-blinded, randomized and controlled clinical trial, we compared the effect of MMF with cyclophosphamide in inducing complete or partial remission (PR) among patients with nephrotic syndrome due to idiopathic MN. All of the patients in both groups also received steroid, renin-angiotensin blockers and statins. Diuretics were also used in the patients who had edema. The primary end point of our study was change in urinary protein/creatinine ratio. Results: A total of 30 patients completed the study. Around 17 patients received MMF (2 g/d) and 13 patients received intravenous or oral cyclophosphamide for 6 months. At the start of the study, no significant differences in demographic and biochemical parameters of patients including the urinary protein excretion rate between two groups (P = 0.432). The proportion of proteinuria was 5235 ± 1655 mg/24 in MMF group and 8781 ± 8741 mg/24 in the cyclophosphamide group at the beginning of the study. The rate of complete and PR were 5.9% and 52.9 in MMF group versus 16.7% and 100% in cyclophosphamide group which it is significantly lower in MMF group. Kidney function was stable in both groups during treatment. Conclusions: According to the result of our study, a 6-month therapy with MMF-glucocorticoid is not recommended for treatment of patients with nephrotic syndrome due to idiopathic MN