Potential Use of Long Noncoding RNAs as Biomarkers for Astrocytoma

Noncoding RNAs represent a high proportion of the human genome and regulate gene expression by means of innumerable and unimaginable modes of action. Particularly, long noncoding RNAs have emerged as central regulators of gene expression and alterations on their function have been associated with many types of cancer, such as astrocytomas. Astrocytomas are the most common type of gliomas in the central nervous system, and glioblastoma multiforme is their most aggressive form. Although adult and pediatric astrocytomas exhibit certain molecular similarities, they are considered as distinct molecular entities. Since to date there is no effective treatments for these tumors, different efforts are being made to find molecular tools useful for this purpose. Studies have shown that both tumor and circulating expression of lncRNAs were altered in astrocytoma, which was useful to distinguish the patients with this neoplasia from those without cancer, as well as to determine different prognostic factors related to the disease. According to these studies, different “molecular signatures” of specific lncRNAs were established, and they have a potential use in the medical practice. From a system biological perspective, complex interaction networks, conformed by lncRNAs, microRNAs, mRNAs, and proteins, were elucidated and predicted to control many oncogenic processes

Pain Acceptance Creates an Emotional Context That Protects against the Misuse of Prescription Opioids: A Study in a Sample of Patients with Chronic Noncancer Pain.

There is solid evidence of an association between several psychological flexibility processes, particularly pain acceptance, and adaptation to chronic pain. However, there are relatively few studies on the relationship between pain acceptance and opioid misuse in chronic pain patients. Thus, the aim of the present study was to test a hypothetical model in which pain acceptance would regulate pain sensations and pain-related thoughts and emotions, which would be related to opioid misuse. The sample comprised 140 chronic pain patients attending two hospitals. All patients were receiving pharmacological treatment, including opioid analgesics. Structural equation modelling analyses showed a significant association between higher pain acceptance and lower pain intensity and catastrophizing, and lower levels of anxiety and depression. Only higher anxiety and depression were significantly associated with increased opioid misuse. The results suggest that levels of anxiety, depression, and pain acceptance must be assessed before opioids are prescribed. Pain acceptance implies a relationship with internal events that protects against anxiety and depression and thus against opioid misuse. Acceptance and Commitment Therapy appears to be particularly appropriate for these patients.This study was supported by grants from the Spanish Ministry of Science and Innovation (PID2019-106086RB-I00) and the Regional Government of Andalusia (HUM-566). Partial funding for open access charge: Universidad de Málaga

Pain Acceptance Creates an Emotional Context That Protects against the Misuse of Prescription Opioids: A Study in a Sample of Patients with Chronic Noncancer Pain.

There is solid evidence of an association between several psychological flexibility processes, particularly pain acceptance, and adaptation to chronic pain. However, there are relatively few studies on the relationship between pain acceptance and opioid misuse in chronic pain patients. Thus, the aim of the present study was to test a hypothetical model in which pain acceptance would regulate pain sensations and pain-related thoughts and emotions, which would be related to opioid misuse. The sample comprised 140 chronic pain patients attending two hospitals. All patients were receiving pharmacological treatment, including opioid analgesics. Structural equation modelling analyses showed a significant association between higher pain acceptance and lower pain intensity and catastrophizing, and lower levels of anxiety and depression. Only higher anxiety and depression were significantly associated with increased opioid misuse. The results suggest that levels of anxiety, depression, and pain acceptance must be assessed before opioids are prescribed. Pain acceptance implies a relationship with internal events that protects against anxiety and depression and thus against opioid misuse. Acceptance and Commitment Therapy appears to be particularly appropriate for these patients

Condition-dependent male copulatory courtship and its benefits for females

Postcopulatory sexual selection has shaped the ornaments used during copulatory courtship. However, we know relatively little about whether these courtship ornaments are costly to produce or whether they provide indirect benefits to females. We used the mealworm beetle, Tenebrio molitor, to explore this. We challenged males using an entomopathogenic fungus and compared their courtship (frequency of leg and antennal contacts to the female), copulation duration, number of eggs laid, and hatching rate against control males. Infected males copulated for longer yet they reduced their leg and antennal contacts compared to control males. However, there was no obvious relation between infection, copulation duration, and courtship with egg production and hatching success. In general, our results indicate that the ornaments used during postcopulatory courtship are condition-dependent. Moreover, such condition dependence cannot be linked to male fitness.Fil: Cargnelutti, Franco Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Reyes Ramírez, Alicia. Universidad Nacional Autónoma de México; MéxicoFil: Cristancho, Shara. Universidad El Bosque; ColombiaFil: Sandoval García, Iván A.. Universidad Nacional Autónoma de México; MéxicoFil: Rocha Ortega, Maya. Universidad Nacional Autónoma de México; MéxicoFil: Calbacho Rosa, Lucía Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Palacino, Freddy. Universidad El Bosque; ColombiaFil: Córdoba Aguilar, Alex. Universidad Nacional Autónoma de México; Méxic

Implementación de un proyecto deportivo en la localidad las Torres de San Borja “San Borja fútbol club”

RESUMEN La Universidad Privada del Norte, está constantemente impulsando proyectos de responsabilidad social que sean sostenibles en el tiempo y que sean desarrollados y aplicados por los estudiantes, con el fin de crear conciencia sobre los problemas sociales que aquejan a todo el mundo. Por ello, nuestro equipo de trabajo se enfocó en el desarrollo del deporte y las actividades físicas y recreación como herramientas para la buena educación de los niños del A.A.H.H., ya que estos tienen un papel importante en nuestra sociedad, y son fundamentales para el apoyo de una mejor calidad de vida para las personas. En nuestra ciudad existen dependencias que apoya y fomentan la práctica deportiva, y brindan las instalaciones necesarias para llevar a cabo el ejercicio físico. Por otra parte la recreación es otra opción para aquellas personas que no necesariamente practican alguna actividad deportiva, haciendo uso de espacios abiertos y cerrados para llevar a cabo sus relaciones sociales, familiares o simplemente para apartarse un poco de la vida cotidiana. El deporte es forjador de disciplina, de cultura del cuidado del cuerpo, aparte de formador de actitud y generador de una buena condición física y salud. Por esta razón es importante la realización de un proyecto de carácter deportivo que sirva y favorezca al cuidado físico de las personas, mediante instalaciones adecuadas y que estén apegadas a las normas que rigen este tipo de espacio público. Hoy en día encontramos en un momento en el que el modelo actual que sustenta el deporte en edad escolar se encuentra obsoleto. Esta situación hace necesario recuperar las actividades físicas y deportivas. Surgen así los proyectos deportivos como el de torres de san Borja futbol club. Este proyecto se lleva a cabo con niños y niñas de la localidad de torres de San Borja un pueblo que se encuentra en el distrito de moche, cuyas edades se encuentran a partir de los 3 años hasta los 13. Este proyecto abarca los conocimientos del deporte enseñando así distintos deportes como también ciertos valores que se practican en estas disciplinas teniendo como objetivo general Formar niños y niñas deportistas que vean el deporte como una opción para salir adelante. , las charlas sobre valores y el juego limpio el fútbol, vóley son indispensables para que los niños puedan ejercer el deporte de una buena manera , así también el entrenamiento físico que ayuda a los niños a no sufrir lesiones o algunos calambres que se puedan dar durante alguna disciplina.ABSTRACT The UPN (Universidad Privada del Norte), is constantly promoting social responsibility projects that are sustainable over time and that make applicants for students, in order to raise awareness about social problems that do so to everyone. Therefore, our team focused on the development of sport and physical activities and recreation as tools for good education of the children of AAHH, which have an important role in our society, and are fundamental for the support of a better quality of life for people. In our city there are dependencies that support and encourage sports, and provide the necessary facilities to carry out physical exercise. On the other hand, recreation is another option for people who do not necessarily practice sports, making use of open and closed spaces to carry out their social, family or simply for the future of daily life. Sport is a forger of discipline, of body care culture, attitude training and generator of good physical condition and health. This is the reason why a sports project that serves and promotes the physical care of people, through adequate facilities and that are prepared for the rules that govern this type of public space. Today there is a time when the real model that sustains sport at school age is obsolete. This situation makes it necessary to recover physical and sports activities. Thus, sports projects such as the San Borja soccer club emerge. This project is carried out with children from the town of San Borja, a town that is located in the district of Moche, whose ages are from 3 years to 13 years. This project covers the knowledge of sport how to teach young children and also athletes who come to sport as an option to survive on, talks about values and fair play football, the indispensable child for children to use, sports in a good way, the child who has no injuries or some cramps that are injured during the night discipline

Does Pain Catastrophizing and Distress Intolerance Mediate the Relationship Between PTSD and Prescribed Opioid Misuse in People With Chronic Noncancer Pain?

Última versión de borrador en PDFObjective: There is an ongoing debate on the use of long-term high-dose medically prescribed opioid analgesics for patients with chronic noncancer pain. Such use is elevated when there is comorbid pain and PTSD, which is quite prevalent. Therefore, it is relevant to investigate the psychological variables that may explain opioid misuse in this population. The purpose of this study was to examine the interaction effect of PTSD severity, distress intolerance, and pain catastrophizing on prescribed opioid misuse in chronic noncancer pain patients. Method: A total of 168 participants (M age = 60 years, 74% women) were assessed regarding opioid medication, pain intensity, traumatic psychological events, PTSD, distress intolerance, pain catastrophizing, and current opioid misuse. Results: Groups were formed according to the level of PTSD severity (no symptoms, moderate symptoms, and severe symptoms). Significant differences were found between the groups in pain intensity, catastrophizing, distress intolerance, and opioid misuse. The severe-symptoms group had the highest scores on all variables. There were no between-group differences in the prescribed medication. Mediation analysis showed that the relationship between PTSD severity and opioid misuse was completely and independently mediated by distress intolerance and pain catastrophizing. Conclusions: Distress intolerance and pain catastrophizing may be theoretically and clinically relevant constructs in understanding the motivation for opioid misuse in people with concurrent chronic noncancer pain and PTSD

Variables psicológicas implicadas en el abuso o uso indebido de opioides en pacientes con dolor crónico no oncológico.

Las variables psicológicas permiten predecir el riego de abuso de los opioides de prescripción. El objetivo del presente estudio ha sido analizar el valor predictivo de algunas de ellas. Concretamente se ha analizado la asociación del humor de autoafirmación, el neuroticismo, la extraversión, la presencia de síntomas de ansiedad y/o depresión, y la intensidad de dolor percibido con el potencial abuso y el uso indebido de opioides. Participaron 60 pacientes con dolor crónico no oncológico, con una media de edad de 60 años, en su mayoría mujeres (77%) y casados (78%). Se realizaron dos análisis de regresión lineal múltiple por pasos. Los resultados señalan a los síntomas de ansiedad y/o depresión como únicas variables relacionadas con el potencial abuso y el actual uso indebido de los opioides de prescripción. Se concluye la importancia de llevar a cabo una evaluación psicológica previa al inicio de una terapia farmacológica con opioides. Y, en el caso de detectar síntomas de ansiedad o depresión en estos pacientes, sería necesario solucionar estos problemas antes de la prescripción de opioides

The modulation of the hexosamine biosynthetic pathway impacts the localization of CD36 in macrophages

CD36 is a type 2 cell surface scavenger receptor expressed in various tissues. In macrophages, CD36 recognizes oxidized low-density lipoprotein (ox-LDL), which promotes the formation of foam cells, the first step toward an atherosclerotic arterial lesion. CD36 possesses a variety of posttranslational modifications, among them N-glycosylation and O-GlcNAc modification. Some of the roles of these modifications on CD36 are known, such as N-linked glycosylation, which provides proper folding and trafficking to the plasma membrane in the human embryonic kidney. This study aimed to determine whether variations in the availability of UDP-GlcNAc could impact Rab-5-mediated endocytic trafficking and, therefore, the cellular localization of CD36. These preliminary results suggest that the availability of the substrate UDP-GlcNAc, modulated in response to treatment with Thiamet G (TMG), OSMI-1 (O-GlcNAcylation enzymes modulators) or Azaserine (HBP modulator), influences the localization of CD36 in J774 macrophages, and the endocytic trafficking as evidenced by the regulatory protein Rab-5, between the plasma membrane and the cytoplasm

Experiencia vivencial: Elaboración de documental “Torres de San Borja” en el marco del Proyecto Uniones

Resumen El presente documento describe los detalles de la realización del documental “Torres de San Borja”, cuya finalidad es crear conciencia sobre las dificultades que enfrenta el asentamiento humano del mismo nombre y alentar al apoyo de esta comunidad mediante la Responsabilidad Social. Para ello se realizaron visitas a la zona de intervención buscando familias dispuestas a ser entrevistadas, estas entrevistas fueron grabadas y editadas en formato documental con la intención de que sea proyectada públicamente y frente a los protagonistas del documental. Estas actividades se llevaron a cabo exitosamente congregando a 59 personas en total.Abstract This document describes the details of the documentary film "Torres de San Borja", whose purpose is to raise awareness of the difficulties faced by the human settlement with the same name and to encourage the support of this community through social responsibility. To do this, we have to visit the intervention area, looking for families who wants to support us with the interviews, these interviews were recorded and edited in a documentary format with the intention of being projected openly and in front of the protagonists of the documentary. These activities were successfully carried out with 59 participants

Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease

ObjectiveLow HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have examined the underlying genetic basis. Our purpose was to identify genetic variants associated with HDL-C levels and cardiovascular risk in the Mexican population.Approach and resultsA genome-wide association studies for HDL-C levels in 2335 Mexicans, identified four loci associated with genome-wide significance: CETP, ABCA1, LIPC, and SIDT2. The SIDT2 missense Val636Ile variant was associated with HDL-C levels and was replicated in 3 independent cohorts (P=5.9×10−18 in the conjoint analysis). The SIDT2/Val636Ile variant is more frequent in Native American and derived populations than in other ethnic groups. This variant was also associated with increased ApoA1 and glycerophospholipid serum levels, decreased LDL-C (low-density lipoprotein cholesterol) and ApoB levels, and a lower risk of premature CAD. Because SIDT2 was previously identified as a protein involved in sterol transport, we tested whether the SIDT2/Ile636 protein affected this function using an in vitro site-directed mutagenesis approach. The SIDT2/Ile636 protein showed increased uptake of the cholesterol analog dehydroergosterol, suggesting this variant affects function. Finally, liver transcriptome data from humans and the Hybrid Mouse Diversity Panel are consistent with the involvement of SIDT2 in lipid and lipoprotein metabolism.ConclusionsThis is the first genome-wide association study for HDL-C levels seeking associations with coronary artery disease in the Mexican population. Our findings provide new insight into the genetic architecture of HDL-C and highlight SIDT2 as a new player in cholesterol and lipoprotein metabolism in humans