Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction : insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial

Aims Vericiguat reduced the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization in patients with worsening HF with reduced ejection fraction (HFrEF) and a lower limit of baseline estimated glomerular filtration rate (eGFR) of 15 mL/min/1.73 m(2). We evaluated the relationship between the efficacy of vericiguat and baseline and subsequent changes in renal function. Methods and results In VICTORIA, core laboratory serum creatinine was measured at baseline (n = 4956) and weeks 16, 32, and 48. Worsening renal function (WRF), defined as an increase >= 0.3 mg/dL in creatinine from baseline to week 16, was assessed via a Cox model with respect to subsequent primary events. Mean age was 69 years, 24% were female, and mean baseline eGFR was 61 mL/min/1.73 m(2). During 48 weeks of treatment, the trajectories in eGFR and creatinine with vericiguat were similar to placebo (P = 0.50 and 0.18). The beneficial effects of vericiguat on the primary outcome were not influenced by baseline eGFR (interaction P = 0.48). WRF occurred in 15% of patients and was associated with worse outcomes (adjusted hazard ratio 1.28, 95% confidence interval 1.11-1.47; P < 0.001), but the beneficial effects of vericiguat on the primary outcome were similar in patients with or without WRF (interaction P = 0.76). Conclusion Renal function trajectories were similar between vericiguat- and placebo-treated patients and the beneficial effects of vericiguat on the primary outcome were consistent across the full range of eGFR and irrespective of WRF.Peer reviewe

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid spine of hIAPP. Using the cryoEM method MicroED, we discover that one segment, 19-29 S20G, forms pairs of β-sheets mated by a dry interface that share structural features with and are similarly cytotoxic to full-length hIAPP fibrils. In contrast, a second segment, 15-25 WT, forms non-toxic labile β-sheets. These segments possess different structures and cytotoxic effects, however, both can seed full-length hIAPP, and cause hIAPP to take on the cytotoxic and structural features of that segment. These results suggest that protein segment structures represent polymorphs of their parent protein and that segment 19-29 S20G may serve as a model for the toxic spine of hIAPP

Composición química de extractos obtenidos por destilaciónextracción simultánea con solvente de hojas e inflorescencias de nueve especies y/o variedades de albahacas (ocimum spp.)

Se determinó la composición química de extractos obtenidos por destilaciónextracción simultánea con solvente (SDE) de nueve especies y/o variedades de Ocimum spp. (albahacas moradas, reina, híbrida, cítrica y americana; síguemes morado y blanco). La identificación de los compuestos se realizó por GC-MS y por comparación de sus espectros de masas con los de las bases de datos QuadLib, NIST02 y Wiley138 e índices de retención de Kovàts. Los siguientes fueron los compuestos mayoritarios identificados en los extractos: eucaliptol, linalol, nerol, geraniol, neral, geranial, estragol, eugenol y transcinamato de metilo

Composición química de extractos obtenidos por destilaciónextracción simultánea con solvente de hojas e inflorescencias de nueve especies y/o variedades de albahacas (ocimum spp.)

Se determinó la composición química de extractos obtenidos por destilaciónextracción simultánea con solvente (SDE) de nueve especies y/o variedades de Ocimum spp. (albahacas moradas, reina, híbrida, cítrica y americana; síguemes morado y blanco). La identificación de los compuestos se realizó por GC-MS y por comparación de sus espectros de masas con los de las bases de datos QuadLib, NIST02 y Wiley138 e índices de retención de Kovàts. Los siguientes fueron los compuestos mayoritarios identificados en los extractos: eucaliptol, linalol, nerol, geraniol, neral, geranial, estragol, eugenol y transcinamato de metilo

Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction:insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial

AIMS: Vericiguat reduced the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization in patients with worsening HF with reduced ejection fraction (HFrEF) and a lower limit of baseline estimated glomerular filtration rate (eGFR) of 15 mL/min/1.73 m(2). We evaluated the relationship between the efficacy of vericiguat and baseline and subsequent changes in renal function. METHODS AND RESULTS: In VICTORIA, core laboratory serum creatinine was measured at baseline (n = 4956) and weeks 16, 32, and 48. Worsening renal function (WRF), defined as an increase ≥0.3 mg/dL in creatinine from baseline to week 16, was assessed via a Cox model with respect to subsequent primary events. Mean age was 69 years, 24% were female, and mean baseline eGFR was 61 mL/min/1.73 m(2). During 48 weeks of treatment, the trajectories in eGFR and creatinine with vericiguat were similar to placebo (P = 0.50 and 0.18). The beneficial effects of vericiguat on the primary outcome were not influenced by baseline eGFR (interaction P = 0.48). WRF occurred in 15% of patients and was associated with worse outcomes (adjusted hazard ratio 1.28, 95% confidence interval 1.11–1.47; P < 0.001), but the beneficial effects of vericiguat on the primary outcome were similar in patients with or without WRF (interaction P = 0.76). CONCLUSION: Renal function trajectories were similar between vericiguat‐ and placebo‐treated patients and the beneficial effects of vericiguat on the primary outcome were consistent across the full range of eGFR and irrespective of WRF

Composición y capacidad antioxidante de especies aromáticas y medicinales con alto contenido de timol y carvacrol

Se determinó la composición química de extractos de seis especies vegetales (tomillo, oréganos común, cimarrón, de castilla, rastrero y mejorana) y cuatro aceites esenciales obtenidos por destilación-extracción simultánea con solvente (SDE) y hidrodestilación asistida por la radiación de microondas (MWHD), respectivamente. La separación, detección e identificación de los compuestos se realizó por GC-MS y por comparación de sus espectros de masas con los de patrones y de las bases de datos e índices de retención de Kovàts. Se evaluó la capacidad de atrapamiento del catión-radical ABTS+. ácido 2,2´-azino-bis-(3- etilbenzo-tiazolina-6-sulfónico) por los aceites esenciales

Implementing cognitive behavior therapy for chronic fatigue syndrome in mental health care: a costs and outcomes analysis

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